Article
Cardiac & Cardiovascular Systems
Jurrien H. Kuneman, Gurpreet K. Singh, Stephan Milhorini Pio, Kensuke Hirasawa, David Hautemann, Frank van der Kley, Nina Ajmone Marsan, Juhani Knuuti, Victoria Delgado, Jeroen J. Bax
Summary: Sex differences in left ventricular remodeling and outcome after transcatheter aortic valve implantation (TAVI) were examined in patients with severe aortic stenosis (AS). Women demonstrated better outcome after TAVI compared with men, and men were more likely to have concentric remodeling. The interaction between left ventricular remodeling patterns and sex was not associated with survival.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Biology
Thomas J. Hitchcock, Andy Gardner
Summary: Recent research has focused on the role of kin selection in sexual conflict, investigating how demography influences the evolution of male harming genes in different parts of the genome. Different demographic parameters can drive conflicts between autosomes, sex chromosomes, and cytoplasmic genes, ultimately shaping patterns of sexual conflict.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Cardiac & Cardiovascular Systems
Stefan Frantz, Moritz Jens Hundertmark, Jeanette Schulz-Menger, Frank Michael Bengel, Johann Bauersachs
Summary: Most patients survive acute myocardial infarction, but the prevalence of heart failure is increasing, leading to economic strain on healthcare systems. Pathological changes in the heart significantly impact patient outcomes. Risk factors like diabetes, chronic obstructive pulmonary disease, and female sex can distinctively shape the progression towards heart failure.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Steele C. Butcher, Stephan M. Pio, William K. F. Kong, Gurpreet K. Singh, Arnold C. T. Ng, Rebecca Perry, Ching-Hui Sia, Kian Keong Poh, Ana G. Almeida, Ariana Gonzalez, Mylene Shen, Tiong Cheng Yeo, Miriam Shanks, Bogdan A. Popescu, Laura Galian Gay, Marcin Fijalkowski, Michael Liang, Edgar Tay, Nina Ajmone Marsan, Joseph Selvanayagam, Fausto Pinto, Jose L. Zamorano, Philippe Pibarot, Arturo Evangelista, Jeroen J. Bax, Victoria Delgado
Summary: The study found that LV hypertrophy or remodelling were independently associated with the composite endpoint of AV repair/replacement and all-cause mortality for patients with isolated AS and isolated AR, although not for patients with MAVD.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
Magnus Nakrem Lyngbakken, Brede Kvisvik, Trygve Berge, Mohammad Osman Pervez, Erika Nerdrum Aagaard, Inger Ariansen, Torbjorn Omland, Arnljot Tveit, Kjetil Steine, Helge Rosjo
Summary: This study assessed the relationship between serial blood pressure measurements and the risk of cardiovascular disease. The results showed that serial blood pressure measurements are more closely associated with left ventricular remodeling and cardiovascular outcomes than individual blood pressure measurements.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Yusuke Adachi, Arihiro Kiyosue, Jiro Ando, Takuya Kawahara, Satoshi Kodera, Shun Minatsuki, Hironobu Kikuchi, Toshiro Inaba, Hiroyuki Kiriyama, Kazutoshi Hirose, Hiroki Shinohara, Akihito Saito, Takayuki Fujiwara, Hironori Hara, Kazutaka Ueda, Kenichi Sakakura, Masaru Hatano, Mutsuo Harada, Eiki Takimoto, Hiroshi Akazawa, Hiroyuki Morita, Shin-Ichi Momomura, Hideo Fujita, Issei Komuro
Summary: Determinants of left ventricular reverse remodelling (LVRR) following PCI in CAD patients with reduced LVEF include factors such as unprotected left main coronary artery (LMCA) intervention, prior PCI, presence of in-stent restenosis, and presence of de-novo stenosis. These data indicate the potential prognostic benefit of unprotected LMCA intervention for LVRR and the importance of angiographic follow-up in patients with CAD and LV systolic dysfunction.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Anping Cai, Lin Liu, Dan Zhou, Yingling Zhou, Songtao Tang, Yingqing Feng
Summary: This study aimed to evaluate the associations between general and abdominal obesity with left ventricular structure and function, finding that both types of obesity were related to different patterns of LV alterations, with no differences in associations by sex.
Article
Developmental Biology
Corey Bunce, Lindsey Barske, Gloria Zhang, Blanche Capel
Summary: During mammalian development, the commitment of bipotential supporting cells to Sertoli or granulosa cell fates plays a crucial role in gonadal sex determination. In XY mice, failure of unified commitment leads to the formation of an ovotestis, where central supporting cells develop as Sertoli cells while pole supporting cells develop as granulosa cells. However, contrary to previous beliefs, the expression of SRY and SOX9, the drivers of Sertoli cell fate, is not limited to the central domain and Sertoli cell fate is not spread through paracrine relay among supporting cells. Instead, there is a center-biased pattern of supporting cell precursor ingression, resulting in increased supporting cell density in the central domain.
Article
Cardiac & Cardiovascular Systems
Pankaj Puar, Makoto Hibino, C. David Mazer, Andrew T. Yan, Arjun K. Pandey, Adrian Quan, Hwee Teoh, David A. Hess, Raj Verma, Kim A. Connelly, Subodh Verma
Summary: The study found that empagliflozin use for 6 months resulted in a significant reduction in left ventricular mass indexed to body surface area (LVMi) in patients with type 2 diabetes and coronary artery disease. Further analysis showed that patients with higher baseline LVMi experienced greater improvement with the use of the drug.
CARDIOVASCULAR DIABETOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Sadia Perveen, Daniela Rossin, Emanuela Vitale, Rachele Rosso, Roberto Vanni, Caterina Cristallini, Raffaella Rastaldo, Claudia Giachino
Summary: Myocardial infarction is a leading cause of heart-related deaths worldwide, and the potential of acellular scaffolds in treating MI is significant, as they can improve cardiac regeneration, limit adverse LV remodelling, and enhance heart function recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Renan Sauteraud, Jill M. Stahl, Jesica James, Marisa Englebright, Fang Chen, Xiaowei Zhan, Laura Carrel, Dajiang J. Liu
Summary: The X Chromosome plays a crucial role in human development and disease, with XCI influencing the expression of escape genes and impacting the etiology of sex-biased disorders. Research indicates that escape genes, particularly those with Y homology, contribute significantly to X heritability. Additionally, the enrichment of variable escape genes is higher in female-biased diseases, highlighting their importance in the disease mechanism.
Article
Cardiac & Cardiovascular Systems
Jan Stassen, See Hooi Ewe, Kensuke Hirasawa, Steele C. Butcher, Gurpreet K. Singh, Mohammed R. Amanullah, Kenny Y. K. Sin, Zee P. Ding, Stephan M. Pio, Nicholas W. S. Chew, Ching-Hui Sia, William K. F. Kong, Kian Keong Poh, David J. Cohen, Philippe Genereux, Martin B. Leon, Nina Ajmone Marsan, Victoria Delgado, Jeroen J. Bax
Summary: This study evaluated the association between different left ventricular remodelling patterns and outcomes in patients with moderate aortic stenosis. The results showed that patients with concentric hypertrophy and eccentric hypertrophy had higher mortality rates and were more likely to experience death or aortic valve replacement.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR IMAGING
(2022)
Article
Medicine, General & Internal
George Pavlidis, Damianos Tsilivarakis, Konstantinos Katogiannis, Dimitrios Vlastos, Spyridon Katsanos, Eleni Katsanaki, John Thymis, John Parissis, Vaia Lambadiari, Ignatios Ikonomidis
Summary: This study found that aortic stiffness during acute ST-segment elevation myocardial infarction is associated with long-term left ventricular remodelling.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Behavioral Sciences
David E. Ausband
Summary: Offspring sex ratios in gray wolves in Idaho are male-biased, reflecting sex-biased dispersal in the population. This may be a strategy used by breeding females to reduce future local resource competition. Individual, group, and population characteristics were not significantly associated with offspring sex ratios.
BEHAVIORAL ECOLOGY AND SOCIOBIOLOGY
(2022)
Article
Ecology
Keryea Soong, Guan-Lin Yu, Chia-Hsuan Hsu, Gwo-Liang Chang, Shi-Jie Lin
Summary: A study on sea urchins in southern Taiwan revealed biased sex ratios, with higher mortality rates among females possibly causing the imbalance. The hypotheses of Sampling Bias and Innate mechanisms failed to explain the phenomenon, while the Differential Mortality Hypothesis provided a more plausible explanation for the skewed sex ratios observed in the population.
REGIONAL STUDIES IN MARINE SCIENCE
(2021)
Review
Endocrinology & Metabolism
Andrea Rodrigues Sabbatini, Georgios Kararigas
BIOLOGY OF SEX DIFFERENCES
(2020)
Editorial Material
Endocrinology & Metabolism
Dawn A. Lowe, Georgios Kararigas
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Ioannis D. Kyriazis, Matthew Hoffman, Lea Gaignebet, Anna Maria Lucchese, Eftychia Markopoulou, Dimitra Palioura, Chao Wang, Thomas D. Bannister, Melpo Christofidou-Solomidou, Shin-Ichi Oka, Junichi Sadoshima, Walter J. Koch, Ira J. Goldberg, Vincent W. Yang, Agnieszka B. Bialkowska, Georgios Kararigas, Konstantinos Drosatos
Summary: The study revealed that diabetic cardiomyopathy (DbCM) is associated with increased cardiac expression of KLF5, which is regulated by FOXO1. KLF5 induces DbCM by promoting oxidative stress through NOX4 and ceramide accumulation in the heart. Inhibiting KLF5 could alleviate superoxide formation and improve cardiac function in diabetic mice.
CIRCULATION RESEARCH
(2021)
Letter
Medicine, General & Internal
Oliver Ritter, Georgios Kararigas
MAYO CLINIC PROCEEDINGS
(2021)
Article
Cardiac & Cardiovascular Systems
Sophie Garnier, Magdalena Harakalova, Stefan Weiss, Michal Mokry, Vera Regitz-Zagrosek, Christian Hengstenberg, Thomas P. Cappola, Richard Isnard, Eloisa Arbustini, Stuart A. Cook, Jessica van Setten, Jorg J. A. Calis, Hakon Hakonarson, Michael P. Morley, Klaus Stark, Sanjay K. Prasad, Jin Li, Declan P. O'Regan, Maurizia Grasso, Martina Mueller-Nurasyid, Thomas Meitinger, Jean-Philippe Empana, Konstantin Strauch, Melanie Waldenberger, Kenneth B. Marguiles, Christine E. Seidman, Georgios Kararigas, Benjamin Meder, Jan Haas, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Jeanette Erdmann, Stefan Blankenberg, Thomas Wichter, Volker Ruppert, Luigi Tavazzi, Olivier Dubourg, Gerard Roizes, Richard Dorent, Pascal de Groote, Laurent Fauchier, Jean-Noel Trochu, Jean-Francois Aupetit, Zofia T. Bilinska, Marine Germain, Uwe Voelker, Daiane Hemerich, Ibticem Raji, Delphine Bacq-Daian, Carole Proust, Paloma Remior, Manuel Gomez-Bueno, Kristin Lehnert, Renee Maas, Robert Olaso, Ganapathi Varma Saripella, Stephan B. Felix, Steven McGinn, Laetitia Duboscq-Bidot, Alain van Mil, Celine Besse, Vincent Fontaine, Helene Blanche, Flavie Ader, Brendan Keating, Angelique Curjol, Anne Boland, Michel Komajda, Francois Cambien, Jean-Francois Deleuze, Marcus Doerr, Folkert W. Asselbergs, Eric Villard, David-Alexandre Tregoueet, Philippe Charron
Summary: This study conducted the largest genome-wide association study on dilated cardiomyopathy, identifying new DCM-associated loci on chromosomes 3p25.1 and 22q11.23. A genetic risk score based on risk alleles at these loci showed a 3-fold increased risk of DCM. Functional analyses suggest SLC6A6 and SMARCB1 as candidate genes at the identified loci, shedding light on novel biological pathways underlying heart failure.
EUROPEAN HEART JOURNAL
(2021)
Review
Biochemistry & Molecular Biology
Siavash Beikoghli Kalkhoran, Georgios Kararigas
Summary: Biological sex influences disease development and progression. The hormone 17 beta-oestradiol (E2), along with its receptors, plays a major role in sex differences. E2 regulates mitochondrial dynamics by modulating fusion-fission dynamics and affects cellular metabolism. This article discusses the regulatory pathways of E2 in cardiovascular and nervous systems and concludes that E2 maintains mitochondrial function by promoting fusion and attenuating fission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Editorial Material
Physiology
Georgios Kararigas
PHYSIOLOGICAL REVIEWS
(2022)
Review
Cardiac & Cardiovascular Systems
Shuangyue Li, Georgios Kararigas
Summary: There has been a recent surge of interest in the role of gut microbiota in cardiovascular diseases, with a focus on the potential sex differences in microbial composition and function. This article discusses the contribution of gut microbiota in the development and progression of CVD, as well as how sex hormones may influence the gut microbiome. Understanding these relationships could lead to innovative strategies for preventing, diagnosing, and treating CVD in both men and women.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Hester M. den Ruijter, Georgios Kararigas
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Gaia Spinetti, Martina Mutoli, Simona Greco, Federica Riccio, Soumaya Ben-Aicha, Franziska Kenneweg, Amela Jusic, David de Gonzalo-Calvo, Anne Yael Nossent, Susana Novella, Georgios Kararigas, Thomas Thum, Costanza Emanueli, Yvan Devaux, Fabio Martelli
Summary: Diabetes mellitus, a metabolic disorder characterized by high blood glucose levels, is a major risk factor for cardiovascular diseases. Chronic or intermittent hyperglycemia in diabetes leads to vascular damage and inflammation, resulting in micro- and macro-vascular diseases. Non-coding RNAs (ncRNAs) may play a fundamental role in the interaction between immune and cardiovascular cells in diabetic complications. This review explores the function of ncRNAs as biomarkers and treatment targets, as well as their involvement in the increased cardiovascular risk in diabetic patients with Sars-CoV-2 infection.
CARDIOVASCULAR DIABETOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Miron Sopic, Georgios Kararigas, Yvan Devaux, Paolo Magni
EUROPEAN HEART JOURNAL
(2023)
Review
Microbiology
Andrea Garcia-Llorca, Georgios Kararigas
Summary: Metabolic syndrome (MetS) is a complex disease involving metabolic abnormalities and is associated with an increased risk of cardiovascular disease (CVD). Diabetic retinopathy (DR) is a major complication in type 2 diabetic (T2D) patients and can lead to vision loss. The gut microbiota, with their composition and diversity, have been identified as potential risk factors for the development of MetS, T2D, DR, and CVD. Biomarkers are used to monitor biological processes, therapeutic responses, and detect pathogenic disorders. This article discusses the molecular mechanisms of MetS, the role of biological sex in MetS-related DR and gut microbiota, and the latest advances in biomarker research.
Article
Physiology
Anja Angelov, Paul J. Connelly, Christian Delles, Georgios Kararigas
Summary: This article summarizes the pronounced sex differences in the development and outcome of APOA1 and discusses the sex-biased and sex hormone-dependent regulation of APOA1. The authors suggest that studying the effects of biological sex will contribute to a better understanding of the role of APOA1 in cardiovascular physiology and its sex-biased association with CVD. They also emphasize the need for more sex-stratified data in situations of sex hormone therapy or inhibition.
CURRENT OPINION IN PHYSIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Georgios Siokatas, Ioanna Papatheodorou, Angeliki Daiou, Antigone Lazou, Konstantinos E. Hatzistergos, Georgios Kararigas
Summary: Cardiovascular diseases are the leading cause of death and disability, and male and female patients show significant differences in disease mechanisms and treatment responses. This review discusses the current knowledge and gaps in understanding the relationship between heart development and primary and secondary sex determination factors. The influence of abnormal sex determination on cardiovascular manifestations in humans and different species, as well as the role of sex hormones in cardiac repair mechanisms, are specifically covered. Understanding the sex determination-heart axis may lead to new therapeutic approaches for cardiac regeneration and repair.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2022)
