Review
Immunology
Atsushi Kawakami, Yushiro Endo, Tomohiro Koga, Koh-ichiro Yoshiura, Kiyoshi Migita
Summary: The innate immune system uses sensors like Toll-like receptors and nucleotide-binding domain leucine-rich repeat proteins to recognize pathologic factors, while inflammasomes are key sensors responding to pathologic external factors and endogenous damage-associated molecular pattern signals. Recent research has identified novel findings in inflammasome biology and genetics, leading to changes in diagnosis and management of autoinflammatory diseases.
INFLAMMATION AND REGENERATION
(2022)
Article
Cell Biology
Leila Bahari Khasraghi, Morteza Nouri, Masoud Vazirzadeh, Nasrin Hashemipour, Mehrdad Talebi, Fatemehsadat Aghaei Zarch, Jamal Majidpoor, Kambiz Kalhor, Poopak Farnia, Sajad Najafi, Seyed Mohsen Aghaei Zarch
Summary: miR-206 plays a dual role in cancer, acting as either a tumor suppressor or an oncogene. Restoring tumor-suppressor miR-206 has emerged as an unconventional strategy for cancer treatment, potentially leading to more significant treatment outcomes for cancer patients.
CELLULAR SIGNALLING
(2023)
Review
Oncology
Shirin Hafezi, Mohamed Rahmani
Summary: Apoptosis is the main form of cell death regulated by the BCL-2 family of proteins. Overexpression of antiapoptotic proteins in malignant cells offers survival advantages but also presents opportunities for targeted therapies. Studies targeting BCL-2 proteins, including the development of venetoclax, show promise for effective treatment in cancer.
Review
Genetics & Heredity
Wei Gao, Yigui Chen, Jianwei Yang, Changhua Zhuo, Sha Huang, Hui Zhang, Yi Shi
Summary: Liquid biopsy, analyzing circulating biological components in body fluids, has shown promising potential in overcoming limitations of conventional tissue biopsies. In the context of metastatic colorectal cancer, liquid biopsy can provide clinical benefits by identifying various biomarkers that aid in diagnosis, prognosis prediction, and therapy response monitoring.
FRONTIERS IN GENETICS
(2021)
Review
Biochemistry & Molecular Biology
Shozo Okamoto, Tohru Shiga, Nagara Tamaki
Summary: Theranostics, a precision medicine that integrates diagnostic nuclear medicine and radionuclide therapy, will become an ever-increasing part of clinical nuclear medicine, targeting specific biological pathways or receptors for various cancers throughout the body.
Review
Biotechnology & Applied Microbiology
Madhusudhan Alle, Garima Sharma, Seung-Hwan Lee, Jin-Chul Kim
Summary: Cancer remains a significant threat to human life with current treatment options unable to prevent millions of deaths each year. Nanoparticles, particularly nanogold (AuNPs), offer a promising approach for effective cancer treatment through modulation of their size, shape, and attachment of targeting agents. This review focuses on recent advancements in functionalizing AuNPs-based nanoconstructs for cancer imaging and therapy using combinatorial multimodal approaches, including photothermal therapy, photodynamic therapy, chemotherapy, radiotherapy, and immunotherapy.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Review
Immunology
Keywan Mortezaee, Jamal Majidpoor
Summary: Dysregulated immune responses, particularly the dysfunction of CD8(+) T cells, play a significant role in SARS-CoV-2-induced disease and cancer. Overactive CD8(+) T cells in the lung and tumor microenvironment become exhausted and undergo apoptosis, leading to diminished immunity. Therefore, strategies to restore the functionality of CD8(+) T cells are crucial for overcoming these diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Ryungsa Kim, Takanori Kin
Summary: The development of adjuvant and neoadjuvant therapies, along with breast cancer surgery, has significantly improved survival rates of breast cancer patients over the past 50 years. However, distant metastasis recurrence remains a challenge, despite advancements in treatment. Further research in antitumor immunity, drug resistance, and targeted therapy based on genomic analysis is needed to achieve complete cure for primary breast cancer.
Review
Biochemistry & Molecular Biology
Jia Song, Yuexin Ge, Xiaoyu Sun, Qiutong Guan, Shiqiang Gong, Minjie Wei, Jumin Niu, Lin Zhao
Summary: This review examines the roles of the Hh pathway and ncRNAs in cancer development and treatment, as well as their crosstalk. ncRNAs related to the Hh pathway can serve as biomarkers for cancer therapy and targets for further research.
Review
Oncology
Mieczyslaw Dutka, Rafal Bobinski, Tomasz Francuz, Wojciech Garczorz, Karolina Zimmer, Tomasz Ilczak, Michal Cwiertnia, Maciej B. B. Hajduga
Summary: Cancer remains a major cause of death worldwide despite significant advances in its treatment. A new group of antidiabetic drugs, called sodium-glucose cotransporter 2 inhibitors, have recently been found to have beneficial effects in heart failure and renal failure patients, as well as exhibit anticancer effects. However, the mechanisms of their anticancer action are not yet fully understood.
Review
Medicine, General & Internal
Miro E. Raeber, Dilara Sahin, Ufuk Karakus, Onur Boyman
Summary: This study systematically reviews the clinical results of improved IL-2-based compounds. So far, none of these compounds have gained regulatory approval for the treatment of cancer or autoimmune diseases.
Review
Oncology
Justus Koerfer, Florian Lordick, Ulrich T. Hacker
Summary: Gastric cancer is a major global cause of cancer mortality, with systemic treatment like chemotherapy and targeted therapy being the standard of care for advanced/metastatic cases. Recent molecular characterization efforts have identified distinct molecular subtypes, paving the way for targeted therapies based on specific genomic alterations. Ongoing development of promising compounds is expected to advance personalized treatment approaches.
Review
Pharmacology & Pharmacy
Shanshan Hou, Muhammad Hasnat, Ziwei Chen, Yinong Liu, Mirza Muhammad Faran Ashraf Baig, Fuhe Liu, Zelong Chen
Summary: This article outlines the applications of nanomedicine in cancer treatment, focusing on chemotherapy, gene therapy, and immunotherapy. Addressing common problems in these treatment modalities, the article discusses how nanomedicine can be combined with them, provides typical examples, and summarizes the advantages brought by the application of nanomedicine.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Qing-Hua Liu, Ji-Wei Zhang, Lei Xia, Steven G. Wise, Brett David Hambly, Kun Tao, Shi-San Bao
Summary: The expression of IL-31, IL-32, and IL-33 is lower in gastric cancer patients and correlates with clinicopathological parameters, suggesting their potential as biomarkers for gastric cancer detection. Further exploration of the mechanisms underlying the actions of IL-31, IL-32, and IL-33 in gastric cancer is warranted.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Review
Oncology
Nimit Shah, John Squire, Mina Guirguis, Debabrata Saha, Kenneth Hoyt, Ken Kang-Hsin Wang, Vijay Agarwal, Girgis Obaid
Summary: This review summarizes the latest advances in deep-tissue activation technologies for photodynamic therapy (PDT) and discusses both direct and indirect activation mechanisms. The use of nanomaterials has improved the safety and efficacy of PDT and allowed for multifunctionality. The review also explores the potential clinical translation of these activation mechanisms by utilizing currently available clinical instrumentation.
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)