3-B-RUT, a derivative of RUT, protected against alcohol-induced liver injury by attenuating inflammation and oxidative stress

Antrodin A from mycelium of Antrodia camphorata alleviates acute alcoholic liver injury and modulates intestinal flora dysbiosis in mice

(2020) Zhen-Wei Yi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective Effect of Andrographolide on Alleviating Chronic Alcoholic Liver Disease in Mice by Inhibiting Nuclear Factor Kappa B and Tumor Necrosis Factor Alpha Activation

(2020) Yuan Song et al.   JOURNAL OF MEDICINAL FOOD

A representative metalloprotease induces PGE2 synthesis in fibroblast-like synoviocytes via the NF-κB/COX-2 pathway with amplification by IL-1β and the EP4 receptor

(2020) Mariana N. Viana et al.   Scientific Reports

Polystichum braunii extracts inhibit Complete Freund’s adjuvant-induced arthritis via upregulation of I-κB, IL-4, and IL-10, downregulation of COX-2, PGE2, IL-1β, IL-6, NF-κB, and TNF-α, and subsiding oxidative stress

(2020) Ammara Saleem et al.   INFLAMMOPHARMACOLOGY

DNMT3b-mediated methylation of ZSWIM3 enhances inflammation in alcohol-induced liver injury via regulating TRAF2-mediated NF-κB pathway

(2020) Hai-Di Li et al.   CLINICAL SCIENCE

Fluorine-Modified Rutaecarpine Exerts Cyclooxygenase-2 Inhibition and Anti-inflammatory Effects in Lungs

(2019) Chiming Lee et al.   Frontiers in Pharmacology

National Trends and Long-term Outcomes of Liver Transplant for Alcohol-Associated Liver Disease in the United States

(2019) Brian P. Lee et al.   JAMA Internal Medicine

Rutaecarpine ameliorated sepsis-induced peritoneal resident macrophages apoptosis and inflammation responses

(2019) Zhiling Li et al.   LIFE SCIENCES

Treatment with either COX ‐2 inhibitor or 5‐ LOX inhibitor causes no compensation between COX ‐2 pathway and 5‐ LOX pathway in chronic aluminum overload‐induced liver injury in rats

(2019) Hui Xia et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4‐ROS‐ADAM17 pathway

(2019) Si‐yu Zeng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Design, synthesis, and biological evaluation of rutacecarpine derivatives as multitarget-directed ligands for the treatment of Alzheimer's disease

(2019) Mingfei Wu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Protective Effects of Fucoxanthin against Alcoholic Liver Injury by Activation of Nrf2-Mediated Antioxidant Defense and Inhibition of TLR4-Mediated Inflammation

(2019) Jiawen Zheng et al.   Marine Drugs

Rutaecarpine may improve neuronal injury, inhibits apoptosis, inflammation and oxidative stress by regulating the expression of ERK1/2 and Nrf2/HO-1 pathway in rats with cerebral ischemia-reperfusion injury

(2019) Meiyu Han et al.   Drug Design Development and Therapy

Coadministration of ginger extract-Lactobacillus acidophilus (cobiotic) reduces gut inflammation and oxidative stress via downregulation of COX-2 , i-NOS , and c-Myc

(2018) Parneet Kaur Deol et al.   PHYTOTHERAPY RESEARCH

Protective effect of rutaecarpine against t-BHP-induced hepatotoxicity by upregulating antioxidant enzymes via the CaMKII-Akt and Nrf2/ARE pathways

(2017) Sun Woo Jin et al.   FOOD AND CHEMICAL TOXICOLOGY

Evodiamine ameliorates liver fibrosis in rats via TGF-β1/Smad signaling pathway

(2017) Dongmei Yang et al.   Journal of Natural Medicines

Inhibition of Caspase-8 does not protect from alcohol-induced liver apoptosis but alleviates alcoholic hepatic steatosis in mice

(2017) Fengjie Hao et al.   Cell Death & Disease

Fluorocoxib A loaded nanoparticles enable targeted visualization of cyclooxygenase-2 in inflammation and cancer

(2016) Md. Jashim Uddin et al.   BIOMATERIALS

Hepatic macrophages in homeostasis and liver diseases: from pathogenesis to novel therapeutic strategies

(2016) Cynthia Ju et al.   Cellular & Molecular Immunology

Cyclooxygenase 2: its regulation, role and impact in airway inflammation

(2016) N. N. Rumzhum et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Pathogenesis of Alcoholic Liver Disease

(2016) Winston Dunn et al.   Clinics in Liver Disease

Linking Pathogenic Mechanisms of Alcoholic Liver Disease With Clinical Phenotypes

(2016) Laura E. Nagy et al.   GASTROENTEROLOGY

Inflammation in Alcoholic and Nonalcoholic Fatty Liver Disease: Friend or Foe?

(2016) Bin Gao et al.   GASTROENTEROLOGY

Nimesulide, a cyclooxygenase-2 selective inhibitor, suppresses obesity-related non-alcoholic fatty liver disease and hepatic insulin resistance through the regulation of peroxisome proliferator-activated receptor γ

(2016) Shunsuke Tsujimoto et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

(2016) Charlotte L. Scott et al.   Nature Communications

Identification of evodiamine as the bioactive compound in evodia (Evodia rutaecarpa Benth.) fruit extract that activates human peroxisome proliferator-activated receptor gamma (PPARγ)

(2015) John F. Rebhun et al.   FITOTERAPIA

Mechanism-based inhibition of CYPs and RMs-induced hepatoxicity by rutaecarpine

(2015) Fang-Liang Zhang et al.   XENOBIOTICA

Burden of Disease Associated with Alcohol Use Disorders in the United States

(2014) Jürgen Rehm et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

Evodiamine and rutaecarpine alkaloids as highly selective transient receptor potential vanilloid 1 agonists

(2014) Bojidarka Ivanova et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

N-Acetyl-Serotonin Protects HepG2 Cells from Oxidative Stress Injury Induced by Hydrogen Peroxide

(2014) Jiying Jiang et al.   Oxidative Medicine and Cellular Longevity

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Alcoholic Liver Disease: Pathogenesis and New Therapeutic Targets

(2011) Bin Gao et al.   GASTROENTEROLOGY

Pathogenesis of alcohol-induced liver disease: Classical concepts and recent advances

(2011) Devanshi Seth et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Oxidative stress mediates chemical hypoxia-induced injury and inflammation by activating NF-κb-COX-2 pathway in HaCaT cells

(2011) Chuntao Yang et al.   MOLECULES AND CELLS

Evodia rutaecarpaand Three Major Alkaloids Abrogate Influenza A Virus (H1N1)-Induced Chemokines Production and Cell Migration

(2010) Wen-Fei Chiou et al.   Evidence-based Complementary and Alternative Medicine

Alcoholic liver disease and the gut-liver axis

(2010) Gyongyi Szabo   WORLD JOURNAL OF GASTROENTEROLOGY

Alcoholic Hepatitis

(2009) Michael R. Lucey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-redundant Functions of Cyclooxygenases: Oxygenation of Endocannabinoids

(2008) Carol A. Rouzer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and characterization of infiltrating macrophages in acetaminophen-induced liver injury

(2008) Michael P. Holt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CYP2E1 and oxidative liver injury by alcohol

(2007) Yongke Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE