A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
A structural mechanism for directing corepressor-selective inverse agonism of PPARγ
Authors
Keywords
-
Journal
Nature Communications
Volume 9, Issue 1, Pages -
Publisher
Springer Nature America, Inc
Online
2018-11-02
DOI
10.1038/s41467-018-07133-w
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Defining a conformational ensemble that directs activation of PPARγ
- (2018) Ian M. Chrisman et al. Nature Communications
- Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism
- (2018) Jie Zheng et al. STRUCTURE
- The Necessary Nitrogen Atom: A Versatile High-Impact Design Element for Multiparameter Optimization
- (2017) Lewis D. Pennington et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Slow Conformational Switch in the BMAL1 Transactivation Domain Modulates Circadian Rhythms
- (2017) Chelsea L. Gustafson et al. MOLECULAR CELL
- Probing the Complex Binding Modes of the PPARγ Partial Agonist 2-Chloro-N-(3-chloro-4-((5-chlorobenzo[d]thiazol-2-yl)thio)phenyl)-4-(trifluoromethyl)benzenesulfonamide (T2384) to Orthosteric and Allosteric Sites with NMR Spectroscopy
- (2016) Travis S. Hughes et al. JOURNAL OF MEDICINAL CHEMISTRY
- PPARγ helix 12 exhibits an antagonist conformation
- (2016) Filip Fratev PHYSICAL CHEMISTRY CHEMICAL PHYSICS
- PPARG Post-translational Modifications Regulate Bone Formation and Bone Resorption
- (2016) L.A. Stechschulte et al. EBioMedicine
- Long-Time-Step Molecular Dynamics through Hydrogen Mass Repartitioning
- (2015) Chad W. Hopkins et al. Journal of Chemical Theory and Computation
- ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB
- (2015) James A. Maier et al. Journal of Chemical Theory and Computation
- Tactical Approaches to Interconverting GPCR Agonists and Antagonists
- (2015) Peter I. Dosa et al. JOURNAL OF MEDICINAL CHEMISTRY
- Deconvolution of Complex 1D NMR Spectra Using Objective Model Selection
- (2015) Travis S. Hughes et al. PLoS One
- Pharmacological repression of PPARγ promotes osteogenesis
- (2015) David P. Marciano et al. Nature Communications
- Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes
- (2014) Raymond E. Soccio et al. Cell Metabolism
- A Novel Non-agonist Peroxisome Proliferator-activated Receptor γ (PPARγ) Ligand UHC1 Blocks PPARγ Phosphorylation by Cyclin-dependent Kinase 5 (CDK5) and Improves Insulin Sensitivity
- (2014) Sun-Sil Choi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PTRAJ and CPPTRAJ: Software for Processing and Analysis of Molecular Dynamics Trajectory Data
- (2013) Daniel R. Roe et al. Journal of Chemical Theory and Computation
- Using chemical shift perturbation to characterise ligand binding
- (2013) Mike P. Williamson PROGRESS IN NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY
- New concepts in pharmacological efficacy at 7TM receptors: IUPHAR Review 2
- (2012) Terry Kenakin BRITISH JOURNAL OF PHARMACOLOGY
- Subtleties in GPCR drug discovery: a medicinal chemistry perspective
- (2012) Masahiko Fujioka et al. DRUG DISCOVERY TODAY
- NMR line shapes and multi-state binding equilibria
- (2012) Evgenii L. Kovrigin JOURNAL OF BIOMOLECULAR NMR
- Medium Chain Fatty Acids Are Selective Peroxisome Proliferator Activated Receptor (PPAR) γ Activators and Pan-PPAR Partial Agonists
- (2012) Marcelo Vizoná Liberato et al. PLoS One
- Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism
- (2012) Travis S. Hughes et al. STRUCTURE
- iMOSFLM: a new graphical interface for diffraction-image processing withMOSFLM
- (2011) T. Geoff G. Battye et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- Overview of theCCP4 suite and current developments
- (2011) Martyn D. Winn et al. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY
- The Phenix software for automated determination of macromolecular structures
- (2011) Paul D. Adams et al. METHODS
- Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation
- (2011) Jang Hyun Choi et al. NATURE
- R.E.D. Server: a web service for deriving RESP and ESP charges and building force field libraries for new molecules and molecular fragments
- (2011) Enguerran Vanquelef et al. NUCLEIC ACIDS RESEARCH
- An introduction to NMR-based approaches for measuring protein dynamics
- (2010) Ian R. Kleckner et al. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
- Ligand-directed signalling at β-adrenoceptors
- (2010) Bronwyn A. Evans et al. BRITISH JOURNAL OF PHARMACOLOGY
- Inhibition of peroxisome proliferator-activated receptor γ activity suppresses pancreatic cancer cell motility
- (2010) Atsushi Nakajima et al. CANCER SCIENCE
- Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5
- (2010) Jang Hyun Choi et al. NATURE
- A Functional Peroxisome Proliferator-activated Receptor-γ Ligand-binding Domain Is Not Required for Adipogenesis
- (2008) Christopher J. Walkey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal Structure of the Peroxisome Proliferator-Activated Receptor γ (PPARγ) Ligand Binding Domain Complexed with a Novel Partial Agonist: A New Region of the Hydrophobic Pocket Could Be Exploited for Drug Design
- (2008) Roberta Montanari et al. JOURNAL OF MEDICINAL CHEMISTRY
- Potential of Peroxisome Proliferator-Activated Receptor Gamma Antagonist Compounds as Therapeutic Agents for a Wide Range of Cancer Types
- (2008) Jack D. Burton et al. PPAR Research
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started