Article
Clinical Neurology
Robert C. Osorio, Matheus P. Pereira, Taemin Oh, Rushikesh S. Joshi, Alexander F. Haddad, Kaitlyn M. Pereira, Kevin C. Donohue, Zain Peeran, William Carson, Aarav Badani, Elaina J. Wang, Sweta Sudhir, Ankush Chandra, Saket Jain, Angad Beniwal, Jose Gurrola II, Ivan H. El-Sayed, Lewis S. Blevins Jr, Philip V. Theodosopoulos, Sandeep Kunwar, Manish K. Aghi
Summary: This study assessed the correlation between tumor volume and prolactin level in prolactinoma and its impact on surgical outcomes. The results showed a strong association between tumor volume and prolactin levels, with an increase in tumor volume leading to a significant increase in prolactin levels in patients without biochemical remission after surgery.
JOURNAL OF NEUROSURGERY
(2023)
Review
Biochemistry & Molecular Biology
Samridhi Banskota, David C. Adamson
Summary: Pituitary adenomas are tumors that arise in the anterior pituitary gland, most commonly benign and exerting their effects through excess hormone secretion or mass effect. The clinical presentation varies based on the size and hormone secretion of the adenoma.
Article
Oncology
Salvatore Chibbaro, Francesco Signorelli, Davide Milani, Helene Cebula, Antonino Scibilia, Maria Teresa Bozzi, Raffaella Messina, Ismail Zaed, Julien Todeschi, Irene Ollivier, Charles Henry Mallereau, Guillaume Dannhoff, Antonio Romano, Francesco Cammarota, Franco Servadei, Raoul Pop, Seyyid Baloglu, Giovanni Battista Lasio, Florina Luca, Bernard Goichot, Francois Proust, Mario Ganau
Summary: Giant pituitary adenomas are highly invasive tumors, with surgery being the mainstay of treatment. Extended endoscopic endonasal approaches may offer a valuable treatment option for these challenging lesions, with high resection rates, visual improvement, and low complication rates.
Article
Endocrinology & Metabolism
Anna Cho, Greisa Vila, Wolfgang Marik, Sigrid Klotz, Stefan Wolfsberger, Alexander Micko
Summary: In patients with small sellar lesions, Prolactin-Volume-Ratios greater than 100 may serve as a potential predictive marker for the diagnosis of prolactin-producing pituitary adenomas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Kyla Wright, Matthew Lee, Natalie Escobar, Donato Pacione, Matthew Young, Girish Fatterpekar, Nidhi Agrawal
Summary: Considering tumor volume can improve the differentiation between prolactinomas and NFAs, leading to more effective management strategies.
Article
Clinical Neurology
Georgios Mantziaris, Stylianos Pikis, Tomas Chytka, Roman Liscak, Kimball Sheehan, Darrah Sheehan, Selcuk Peker, Yavuz Samanci, Shray K. Bindal, Ajay Niranjan, L. Dade Lunsford, Rupinder Kaur, Renu Madan, Manjul Tripathi, Dhiraj J. Pangal, Ben A. Strickland, Gabriel Zada, Anne-Marie Langlois, David Mathieu, Ronald E. Warnick, Samir Patel, Zayda Minier, Herwin Speckter, Zhiyuan Xu, Rithika Kormath Anand, Jason P. Sheehan
Summary: This study analyzed 375 patients with residual nonfunctioning pituitary adenomas (NFPAs) who were treated with stereotactic radiosurgery (SRS) and compared the outcomes between early treatment and treatment at progression. The results showed that there was no significant difference in tumor control and preservation of hormonal/visual function between SRS at residual NFPA progression and adjuvant SRS. Deferring radiosurgical management to the time of radiological progression could prolong the onset of radiosurgically induced pituitary dysfunction.
JOURNAL OF NEUROSURGERY
(2023)
Article
Endocrinology & Metabolism
Zuleyha Karaca, Kursad Unluhizarci, Fahrettin Kelestimur
Summary: Prolactin (PRL), secreted by lactotroph cells in the anterior pituitary gland, plays a crucial role in various physiological processes such as lactation, reproduction, and neuroprotection. Abnormalities in PRL synthesis and secretion can cause hyperprolactinemia or hypoprolactinemia, with hypoprolactinemia being a less-known and neglected disorder. This condition can lead to lactation failure and may also increase the risk for metabolic abnormalities. The classification of hypopituitarism does not currently include hypoprolactinemia, highlighting the need for a reevaluation of the classification system.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Clinical Neurology
James R. Janopaul-Naylor, Manali Rupji, Jim Zhong, Bree R. Eaton, Naba Ali, Adriana G. Ioachimescu, Nelson M. Oyesiku, Hui-Kuo G. Shu
Summary: Modern LINAC RT is safe and effective for hormonal control and LC in patients with PAs. There was an increase in the proportion of patients requiring pituitary hormone replacement after RT.
WORLD NEUROSURGERY
(2022)
Review
Medicine, General & Internal
Valentina Puglisi, Elisabetta Morini, Fiammetta Biasini, Luisa Vinciguerra, Giuseppe Lanza, Placido Bramanti
Summary: This is a case report on giant pituitary tumor apoplexy, presenting a rare case of an 81-year-old female with this condition. The authors highlight the importance of prompt diagnosis and multidisciplinary management in achieving significant improvement in symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Polly Kirsch, Jessica Kunadia, Shruti Shah, Nidhi Agrawal
Summary: Prolactin plays an important role not only in reproductive physiology, but also in neurohormonal appetite regulation and metabolism. Elevated prolactin levels are associated with worsening metabolic disease, but low prolactin levels could also be metabolically unfavorable. This review discusses the pathophysiology of prolactin-related metabolic changes, as well as the less recognized effects of prolactin on adipose tissue, pancreas, liver, and small bowel. The effects of dopamine agonists on the metabolic profiles of patients with hyperprolactinemia are also discussed.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Yaron Rudman, Hadar Duskin-Bitan, Yossi Manisterski, Barak Pertzov, Amit Akirov, Hiba Masri-Iraqi, Ilan Shimon
Summary: The study on men with macroprolactinoma showed that 84% of cases were controlled with cabergoline treatment, regardless of tumor size. Pituitary surgery and adjuvant radiotherapy further improved long-term response to 91%.
CLINICAL ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Yi Fang, He Wang, Ming Feng, Wentai Zhang, Lei Cao, Chenyu Ding, Hongjie Chen, Liangfeng Wei, Shuwen Mu, Zhijie Pei, Jun Li, Heng Zhang, Renzhi Wang, Shousen Wang
Summary: Accurate predictive models for hormonal prognosis in NFPA were lacking. Machine learning models were developed to assess pituitary hormonal outcomes post-surgery, showing significant changes in hormone levels and the effectiveness of ML in predicting outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Billion Lisa, Verleye Arno, De Block Christophe, Van de Heyning Paul, De Herdt Carlien
Summary: This study conducted a systematic review of 196 cases of giant prolactinomas in adults. By comparing the clinical, biochemical, and radiological characteristics, as well as the management and therapeutic outcomes, between men and women, it was found that giant prolactinomas are more common in men and the most frequent presenting symptom in men is visual impairment, while in women it is amenorrhea.
Article
Neurosciences
Domenico Solari, Luigi Maria Cavallo, Chiara Graziadio, Sergio Corvino, Ilaria Bove, Felice Esposito, Paolo Cappabianca
Summary: Giant pituitary adenomas present a surgical challenge due to their growth patterns and locations. There is no consensus on the optimal surgical strategy, but transcranial or transsphenoidal approaches are commonly used. Endoscopic endonasal approach is preferred, but transcranial approach is more suitable when the tumor has significant intracranial extension. Accurate preoperative evaluation and individualized treatment plans are crucial for long-term effectiveness.
Review
Endocrinology & Metabolism
Sandeep Kumar, Vijaya Sarathi, Anurag Ranjan Lila, Manjeetkaur Sehemby, Saba Samad Memon, Manjiri Karlekar, Shilpa Sankhe, Virendra A. Patil, Nalini Shah, Tushar Bandgar
Summary: Giant prolactinoma (GP) in childhood and adolescence is a rare disease characterized by male predominance and frequent delay/arrest of puberty. Dopamine agonist (DA) monotherapy may be preferred as the first-line treatment.
Article
Endocrinology & Metabolism
Y. A. Unsal, O. O. Gul, S. Cander, C. Ersoy, E. Aydemir, C. Ates, Z. Uzun, E. Armagan, O. Unsal, E. Erturk
Summary: The study aimed to investigate the association between serum 25-hydroxyvitamin D status prior to COVID-19 infection and immune function parameters and clinical outcomes. Patients with lower vitamin D levels had higher inflammatory markers and worse clinical outcomes, suggesting that vitamin D status can be used as a prognostic factor in COVID-19 patients and supplementation can improve clinical outcomes.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Yasemin Aydogan Unsal, Ozen Oz Gul, Busra Gurbuz, Soner Cander, Ensar Aydemir, Canan Ersoy
Summary: This study shows that switching to continuous subcutaneous insulin infusion therapy can improve glycemic control, reduce insulin dosage requirements, and improve patient quality of life by reducing episodes of diabetic ketoacidosis.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)