Review
Biochemistry & Molecular Biology
Sheng-Kang Chiu, Kuo-Wang Tsai, Chia-Chao Wu, Cai-Mei Zheng, Chung-Hsiang Yang, Wan-Chung Hu, Yi-Chou Hou, Kuo-Cheng Lu, You-Chen Chao
Summary: COVID-19 is characterized by significant immune dysfunction, requiring the development of effective treatments; various types of COVID-19 vaccines are under development and optimization, increasing public immunity may enhance vaccine effectiveness; Vitamin D supplementation may help mitigate the progression of COVID-19, but its role in vaccine efficacy remains unclear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
F. M. Panfili, M. Roversi, P. D'Argenio, P. Rossi, M. Cappa, D. Fintini
Summary: The COVID-19 pandemic requires urgent therapeutic interventions, especially for vulnerable populations such as elderly males. Vitamin D has shown promising immunomodulatory effects and may play a role in the prevention and treatment of SARS-CoV-2 infection in both adults and children.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Drishti Ghelani, Simon Alesi, Aya Mousa
Summary: The role of vitamin D in modulating the immune system in the context of COVID-19 has been discussed in research, with evidence suggesting that low levels of vitamin D may lead to poor prognosis but supplementation can help mitigate these effects, although its benefits remain controversial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
James Bernard Walsh, Daniel M. McCartney, Eamon Laird, Kevin McCarroll, Declan G. Byrne, Martin Healy, Paula M. O'Shea, Rose Anne Kenny, John L. Faul
Summary: This review examines the association between vitamin D, SARS-CoV-2 infection, and COVID-19 severity. The authors conclude that there is a causal relationship between low vitamin D status and increased risk of infection and severe COVID-19. They suggest that vitamin D supplementation may be beneficial for improving immunity against SARS-CoV-2, especially in vulnerable populations. The study highlights the prevalence of low vitamin D status among Irish adults.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Sreedhar Subramanian, George Griffin, Martin Hewison, Julian Hopkin, Rose Anne Kenny, Eamon Laird, Richard Quinton, David Thickett, Jonathan M. Rhodes
Summary: Vitamin D deficiency is associated with an increased risk of COVID-19, especially in winter or among individuals with less sunlight exposure or darker skin pigmentation. Some studies have shown an association between vitamin D deficiency and increased severity of COVID-19, but the results of interventional studies are inconclusive.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Medicine, General & Internal
Pierachille Santus, Dejan Radovanovic, Micaela Garziano, Stefano Pini, Giuseppe Croce, Giuseppe Fuccia, Debora Spitaleri, Mara Biasin, Mario Clerici, Daria Trabattoni
Summary: The effects of immunomodulators in patients with COVID-19 pneumonia are still unknown. A study on 16 patients with mild-moderate COVID-19 pneumonia found that immunomodulation by PDT and systemic corticosteroids may aid in restoring the innate response to viral infection. Further research in larger RCTs is needed to confirm these results.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Daniel D. Bikle
Summary: The major cause of morbidity and mortality in Covid-19 is the cytokine storm in the lungs, which leads to inflammation and cell damage in the lungs, resulting in death.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Nutrition & Dietetics
Maria Nicolae, Cristina Maria Mihai, Tatiana Chisnoiu, Adriana Luminita Balasa, Corina Elena Frecus, Larisia Mihai, Vasile Valeriu Lupu, Irina Ion, Alexandru Cosmin Pantazi, Andreea Nelson Twakor, Antonio Andrusca, Claudia Simona Cambrea, Ioan Anton Arghir, Ancuta Lupu, Oana Cristina Arghir
Summary: Acute respiratory tract infections (ARTIs) are a common reason for pediatric visits to doctors. The relationship between ARTI and vitamin D is currently debated, with little consensus on the ideal level of 25(OH)D concentration that provides respiratory tract protection or the effectiveness of vitamin D supplementation in treating respiratory infections. This review examines the immunomodulatory and antiviral functions of vitamin D and its relation to ARTIs, including SARS-CoV-2, in order to determine if there is a connection between disease severity and vitamin D deficiency in children. The results suggest that vitamin D may lower the risk of ARTI, including COVID-19, but more research is needed to support this idea.
Article
Nutrition & Dietetics
Sreedhar Subramanian, Jonathan M. Rhodes, Joseph M. Taylor, Anna M. Milan, Steven Lane, Martin Hewison, Rene F. Chun, Andrea Jorgensen, Paul Richardson, Darshan Nitchingham, Joseph Aslan, Maya Shah, Coonoor R. Chandrasekar, Amanda Wood, Mike Beadsworth, Munir Pirmohamed
Summary: Vitamin D status is not significantly associated with mortality from COVID-19, but extremely low and high levels may be associated with mortality risks.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Review
Food Science & Technology
Jose Manuel Perez de la Lastra, Celia Maria Curieses Andres, Celia Andres Juan, Francisco J. Plou, Eduardo Perez-Lebena
Summary: Phytochemicals from plant extracts are gaining popularity in food science and technology due to their positive effects on human health. Hydroxytyrosol (HXT) and arginine, both natural compounds, have antioxidant and anti-inflammatory properties that may be beneficial in the context of COVID-19 and long COVID. HXT prevents oxidative stress and inflammation, while arginine modulates immune cell activity and reduces pro-inflammatory cytokine production. Further research is needed to fully understand their potential benefits in COVID-19.
Article
Medicine, General & Internal
Hua Huang, Jiawei Zheng, Yan Liu, Qunhe Zhou, Denggao Peng
Summary: This study found that vitamin D status may have effects on the progression and resolution of adult COVID-19 pneumonia induced by the Delta variant, but not the onset of pneumonia.
FRONTIERS IN MEDICINE
(2023)
Letter
Public, Environmental & Occupational Health
Vivek Dixit, Bhavuk Garg, Nishank Mehta, James Pegrum, Dinesh Dhanwal
Summary: Responsive immunity plays a vital role in combating infections, while Vitamin D deficiency globally affects both musculoskeletal health and immunity status. Establishing the role of vitamin D in pathogen destruction is crucial during the COVID-19 pandemic. Implementing a vitamin D awareness program at school level could be an effective health governance policy to educate populations on the importance of vitamin D in overall health.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Anna Puscion-Jakubik, Joanna Bielecka, Monika Grabia, Anita Mielech, Renata Markiewicz-Zukowska, Konrad Mielcarek, Justyna Moskwa, Sylwia K. Naliwajko, Jolanta Soroczynska, Krystyna J. Gromkowska-Kepka, Patryk Nowakowski, Katarzyna Socha
Summary: The study found that individuals with higher education, medical background, or engaged in home exercise were more likely to consume food supplements containing zinc and vitamin D. The consumption of vitamin and mineral supplements was highest among these groups, indicating a high awareness of health and preventive measures.
Article
Biology
Iulia Cristina Bagiu, Ileana Luminita Scurtu, Delia Ioana Horhat, Ion Cristian Mot, Razvan Mihai Horhat, Radu Vasile Bagiu, Ionut Dragos Capraru, Mircea Mihai Diaconu, Ovidiu Adam, Bogdan Ciornei, Dan Dumitru Vulcanescu, Iulius Juganaru, Andrei-Cristian Bondar, Florin George Horhat
Summary: This study identified that CRP, LDH, and vitamin D levels are important biomarkers for COVID-19-positive pediatric patients, while CK levels were mostly within normal ranges. Clinical severity was associated with CRP, LDH, and vitamin D levels.
Article
Immunology
Federica Saponaro, Maria Franzini, Chukwuma Okoye, Rachele Antognoli, Beatrice Campi, Marco Scalese, Tommaso Neri, Laura Carrozzi, Fabio Monzani, Riccardo Zucchi, Alessandro Celi, Aldo Paolicchi, Alessandro Saba
Summary: This study investigated the relationship between vitamin D levels and inflammatory markers in COVID-19 patients. The findings suggest that hypovitaminosis D is associated with higher levels of inflammatory markers and is related to disease severity and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Ceyla Konca Degertekin, Dilek Gogas Yavuz, Zafer Pekkolay, Emre Saygili, Kader Ugur, Arzu Or Koca, Mustafa Unubol, Omercan Topaloglu, Berna Imge Aydogan, Nilufer Ozdemir Kutbay, Zeliha Hekimsoy, Nusret Yilmaz, Mustafa Kemal Balci, Seher Tanrikulu, Yasemin Aydogan Unsal, Canan Ersoy, Tulay Omma, Muge Keskin, Mehmet Muhittin Yalcin, Ilhan Yetkin, Hikmet Soylu, Melia Karakose, Merve Yilmaz, Ersen Karakilic, Hamide Piskinpasa, Adnan Batman, Gulhan Akbaba, Gulsah Elbuken, Cigdem Tura Bahadir, Faruk Kilinc, Muhammet Cuneyt Bilginer, Ozlem Turhan Iyidir, Zeynep Canturk, Banu Aktas Yilmaz, Zeynel Abidin Sayiner, Mustafa Eroglu
Summary: The study showed that postsurgical hypoparathyroidism is the dominant etiology in Turkey, while nonsurgical patients have a higher disease burden, greater need for medications, and an increased risk of complications compared to postsurgical patients.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Pinar Sisman, Irmak Polat, Ensar Aydemir, Remzi Karsi, Ozen Oz Gul, Soner Cander, Canan Ersoy, Erdinc Erturk
Summary: During the COVID-19 pandemic, factors such as female gender, higher BMI and weight, decreased income, presence of diabetic complications and comorbid diseases, worsened glycemic levels, increased carbohydrate consumption, and snacking were associated with higher anxiety and depression scores in patients with diabetes. Depression was higher in patients with type 2 diabetes and the duration of illness was correlated with acute stress levels. It is important to be aware of the impact of acute stress, depression, and anxiety on patients with diabetes during a pandemic.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Endocrinology & Metabolism
Yasemin Aydogan Unsal, Ozen Oz Gul, Busra Gurbuz, Soner Cander, Ensar Aydemir, Canan Ersoy
Summary: This study shows that switching to continuous subcutaneous insulin infusion therapy can improve glycemic control, reduce insulin dosage requirements, and improve patient quality of life by reducing episodes of diabetic ketoacidosis.
INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES
(2022)
Article
Endocrinology & Metabolism
Dilek Gogas Yavuz, Ceyda D. Yazan, Zeliha Hekimsoy, Kadriye Aydin, Naile Gokkaya, Canan Ersoy, Aysen Akalin, Omercan Topaloglu, Berna I. Aydogan, Esra N. A. Dilekci, Ziynet Alphan Uc, Guven B. Cansu, Levent Ozsari, Ozlem T. Iyidir, Mehtap E. Olgun, Lezzan Keskin, Meral Mert, Bulent Can, Kaan Gungor, Tayfun Galip, Zeynep Canturk, Gulsah Elbuken, Zafer Pekkolay, Nilufer O. Kutbay, Goknur Yorulmaz, Ahmet T. Kalkan, Yasemin A. Unsal, Adnan Yay, Baris Karagun, Evin Bozkur
Summary: The study aimed to investigate TSH levels, adherence to LT4 suppression treatment, and the frequency of reaching target TSH levels in DTC patients after surgery. The results showed that a majority of patients did not achieve target TSH levels, and adherence to treatment had an impact on TSH levels. Simplified and practical guidelines are needed to achieve TSH targets.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Neuroimaging
Yasemin Aydoan Nsal, Zen Z. Gul, Co Kun Ate, Ensar Aydemir, Soner Cander, Canan Ersoy, Rifat Zpar, Bahattin Hakyemez, Erdinc Erturk
Summary: This study evaluated the performance of central venous sampling and magnetic resonance imaging in predicting the localization and lateralization of pituitary microadenomas. The results showed that central venous sampling has higher sensitivity in localization, while MRI has similar diagnostic accuracy in lateralizing the tumor.
NEURORADIOLOGY JOURNAL
(2023)
Article
Surgery
Ensar Aydemir, Yasemin Unsal, Coskun Ates, Soner Cander, Ozen Oz Gul, Ozlem Saraydaroglu, Canan Ersoy, Erdinc Erturk
Summary: Atypical parathyroid tumors have similar laboratory and histopathological features to parathyroid cancer, but differ from parathyroid adenomas. This study found that patients with atypical parathyroid tumors have significantly increased levels of serum calcium, parathormone, and alkaline phosphatase, as well as larger tumor sizes.
INDIAN JOURNAL OF SURGERY
(2023)
Article
Medicine, General & Internal
Yasemin Aydogan Unsal, Ozen Oz Gul, Seyma Esenbuga, Coskun Ates, Ensar Aydemir, Soner Cander, Canan Ersoy, Erdinc Erturk
Summary: This study used bioelectrical impedance analysis (BIA) to examine changes in body composition in patients with acromegaly and found that these changes are related to cardiovascular morbidity and mortality. Patients with acromegaly showed altered body composition, such as higher plasma glucose levels and increased insulin resistance index, compared to the control group. This study highlights the importance of using the BIA method to assess body composition in patients with acromegaly.
ERCIYES MEDICAL JOURNAL
(2023)
Letter
Endocrinology & Metabolism
Yasemin Aydogan Unsal, Ozen Oz Gul, Mehmet Refik Goktug, Soner Cander, Canan Ozyardimci Ersoy, Ensar Aydemir, Coskun Ates, Oktay Unsal, Murat Kiyici, Erdinc Erturk
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Yasemin Aydogan Unsal, Ozen Oz Gul, Mehmet Refik Goktug, Soner Cander, Canan Ozyardimci Ersoy, Ensar Aydemir, Coskun Ates, Oktay Unsal, Murat Kiyici, Erdinc Erturk
Summary: This study aimed to identify risk factors for the development of diabetes mellitus after liver transplantation. Results showed that advanced age, male gender, and higher pretransplantation fasting plasma glucose levels were associated with a higher risk of post-liver transplantation diabetes mellitus. It is important to screen liver transplantation candidates for diabetes risk factors and regularly monitor blood glucose levels in these patients.
TURKISH JOURNAL OF ENDOCRINOLOGY AND METABOLISM
(2022)