Article
Biochemistry & Molecular Biology
Yinzhen Sheng, Jiaqian Liao, Ziping Zhang, Yuting Li, Xiwei Jia, Xianyuan Zeng, Yilei Wang
Summary: This study found that miR-34 can indirectly regulate ovarian development by binding to the 3'-UTR of Vtg and VtgR genes and inhibiting their expression.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Multidisciplinary Sciences
Jason Ioannidis, Gunes Taylor, Debiao Zhao, Long Liu, Alewo Idoko-Akoh, Daoqing Gong, Robin Lovell-Badge, Silvana Guioli, Mike J. McGrew, Michael Clinton
Summary: In birds, sex determination is thought to depend on a sex chromosome gene dosage mechanism, with the gene DMRT1 playing a key role. Experiments showed that ZZ chickens lacking DMRT1 developed ovaries instead of testes, while blocking estrogen synthesis in ZW embryos led to testis development, highlighting the interconnected roles of DMRT1 and estrogen in avian sex determination.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Environmental Sciences
Li-Kun Xu, Ke-Yi Ma, Feng-Ying Zhang, Wei Wang, Ling-Bo Ma, Zhong-Wen Jin, Ming Zhao, Wei Chen, Yin Fu, Chun-Yan Ma, Zhi-Qiang Liu
Summary: This study investigated the embryonic development of the mud crab Scylla paramamosain by analyzing three critical parameters: egg color, embryo morphology, and cell division distribution. The findings provide important insights into the embryonic development of the crab and have potential applications in S. paramamosain culture for determining the developmental status and obtaining high-quality seeds.
FRONTIERS IN MARINE SCIENCE
(2023)
Article
Veterinary Sciences
Wenxiao Cui, Shaobin Fang, Ligang Lv, Zhi Huang, Fei Lin, Qingyang Wu, Huaiping Zheng, Shengkang Li, Yueling Zhang, Mhd Ikhwanuddin, Hongyu Ma
Summary: This study investigated the sexual dimorphism in morphology of the mud crab S. paramamosain, identifying key traits for sex differentiation such as abdomen width and carapace measurements. By using correlation and path analyses, a sex discriminant equation was constructed, allowing for accurate sex identification in crablets from the sixth stage of development. The findings contribute to a better understanding of the morphological differentiation mechanism of sex in S. paramamosain.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Yanshe Xie, Changhua Wu, Zicong Li, Zhenfang Wu, Linjun Hong
Summary: Sex determination is crucial for genetic transmission in mammals. Abnormal expression of sex-related genes can lead to disorders of sex development and infertility. However, recent research has focused on artificially regulating sex-related gene expression to predetermine the sex of animal offspring. This paper reviews the mechanisms underlying gonad and primordial germ cell development, aiming to provide new directions for treating disorders of sex development and infertility by manipulating the sex ratio of livestock offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ardavan Farhadi, Shaobin Fang, Yin Zhang, Wenxiao Cui, Huan Fang, Mhd Ikhwanuddin, Hongyu Ma
Summary: In this study, the wingless-type MMTV integration site family member-4 (Wnt4) gene was cloned and functionally studied in mud crab (Scylla paramamosain). The expression of Sp-Wnt4 was found to play crucial roles in ovarian development, with differential expression levels in different tissues and developmental stages. Unilateral eyestalk ablation also affected the expression of Sp-Wnt4 in testis and gill of female crabs. In situ hybridization assay revealed the localization of Sp-Wnt4 transcripts in the cytoplasm of oocyte cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Agriculture, Dairy & Animal Science
Maria Michela Pallotta, Chiara Fogliano, Rosa Carotenuto
Summary: Environmental sex determination is a mode of sex determination influenced by external factors, with temperature being the main determinant for leopard geckos. This study found that, in addition to gonadal differentiation, other genes are involved in the tissue and metabolic sexual differentiation during embryonic development.
Article
Genetics & Heredity
Rui Ruan, Ying Li, Huamei Yue, Huan Ye, Jiali Jin, Jinping Wu, Hao Du, Chuangju Li
Summary: This study aimed to investigate the gene expression differences during gonadal development in Yangtze sturgeon. Transcriptome analyses revealed higher expression levels of genes associated with ovarian development compared to testis development. Knockdown of the foxl2 gene resulted in decreased expression levels of ovarian-related genes, further confirming the crucial role of foxl2 in ovarian differentiation of sturgeons.
Article
Fisheries
Helena Robattini Carvalho, Diogenes Henrique De Siqueira-Silva, Romulo Batista Rodrigues, Louise Nex Spica, Daniel Antonio Rotili, Everton Luis Zardo, Andrea Giannotti Galuppo, Renata Villar, Juan Ramon Esquivel-Muelbert, Jayme Aparecido Povh, Leonardo Barcellos, Danilo Pedro Streit Jr
Summary: The effect of temperature on gonadal development and sex ratio in Brycon orbignyanus was assessed in this study. Fish were kept at three different temperatures (20°C, 23°C, and 26°C) from the beginning of exogenous feeding. Results showed that the sexual pattern was temperature-dependent, with undifferentiated individuals at 20°C and a higher proportion of immature males at 23°C and males in maturation process and regression phase at 26°C. Testosterone levels were quantified in all treatments, while detectable estradiol levels were found only at 23°C. Continuous exposure to 23°C and 26°C favored testicular development, with faster gonadal development observed at 26°C.
Article
Biotechnology & Applied Microbiology
Zhi He, Zhijun Ma, Deying Yang, Qiqi Chen, Zhide He, Jiaxiang Hu, Faqiang Deng, Qian Zhang, Jiayang He, Lijuan Ye, Hongjun Chen, Liang He, Xiaoli Huang, Wei Luo, Shiyong Yang, Xiaobin Gu, Mingwang Zhang, Taiming Yan
Summary: This study identified 721 circRNAs in ricefield eel gonads and discovered 147 differentially expressed circRNAs during sex change, with some (such as novel_circ_0000659, novel_circ_0004005, and novel_circ_0005865) closely involved in sex change. The downregulation of circSnd1 and foxl2, along with their interaction with mal-miR-135b/c, suggests a regulatory role in sex change.
Article
Biotechnology & Applied Microbiology
Wen-Yu Wei, Yi Gong, Xin-Fen Guo, Min Liu, Yu-Lin Zhou, Zhi Li, Li Zhou, Zhong-Wei Wang, Jian-Fang Gui
Summary: In this study, the researchers performed the first transcriptomic analysis of red-tail catfish gonads at different developmental stages using RNA-seq technology. They identified differentially expressed genes that are involved in sex determination and differentiation. The study provides crucial genetic information for sex control research in red-tail catfish and contributes to the understanding of the evolutionary processes of sex determination mechanisms in fish.
Article
Cell Biology
Tian Liu, Ruojiao Li, Liangjie Liu, Shaoxuan Wu, Lijing Zhang, Yajuan Li, Huilan Wei, Ya Shu, Yaxin Yang, Shi Wang, Qiang Xing, Lingling Zhang, Zhenmin Bao
Summary: This study investigates the effect of temperature on gonadal sex differentiation in the scallop Patinopecten yessoensis. The findings suggest that high temperature (21 degrees C) inhibits sex differentiation, while low temperature (11 degrees C) accelerates sex differentiation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Developmental Biology
Francis Poulat
Summary: In vertebrates, gonadal sex determination involves sex-specific transcription factors that control the activation or repression of sex-specific genes by recognizing regulatory elements in the non-coding genome and binding motifs within DNA sequences. Genomic approaches developed in the last 20 years have helped to globally understand the function of nuclear proteins that control complex genetic programs.
SEXUAL DEVELOPMENT
(2021)
Article
Fisheries
Dongfang Sun, Hong Yu, Qi Li
Summary: FOXL2 and DMRT1 are key transcription factors that play critical roles in sex differentiation and gonadal development in the Pacific oyster Crassostrea gigas. Through non-invasive RNA interference, it was shown that both genes are involved in gonadal development through an estrogen signaling pathway, with evidence of antagonism between Foxl2 and Dmrt1 in oysters. These findings provide valuable data for sex control in aquaculture.
Article
Fisheries
Wenxiao Cui, Mengyun Guan, Md Abu Sadek, Fangchun Wu, Qingyang Wu, Huaqiang Tan, Xi Shi, Mhd Ikhwanuddin, Hongyu Ma
Summary: In this study, the first genetic linkage map of hybrid Scylla was constructed, revealing a high-quality map with sex-linked chromosomes. The findings suggest that chromosome synapsis among different species may be an initial inducement for the divergence of chromosomal forms.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.