Glycyrrhetinic acid induces oxidative/nitrative stress and drives ferroptosis through activating NADPH oxidases and iNOS, and depriving glutathione in triple-negative breast cancer cells

Indoleamine 2, 3-dioxygenase 1enhanceshepatocytes ferroptosis in acute immune hepatitis associated with excess nitrative stress

(2020) Ting Zeng et al.   FREE RADICAL BIOLOGY AND MEDICINE

Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma

(2020) Jana Lippmann et al.   Translational Oncology

Reactive Oxygen Species (ROS)-inducing Triterpenoid Inhibits Rhabdomyosarcoma Cell and Tumor Growth through Targeting Sp Transcription Factors

(2019) Ravi Kasiappan et al.   MOLECULAR CANCER RESEARCH

NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis

(2019) Matthew Dodson et al.   Redox Biology

FSP1 is a glutathione-independent ferroptosis suppressor

(2019) Sebastian Doll et al.   NATURE

Iron homeostasis and oxidative stress: An intimate relationship

(2019) Dimitrios Galaris et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caveolin-1 dictates ferroptosis in the execution of acute immune-mediated hepatic damage by attenuating nitrogen stress

(2019) Guanghui Deng et al.   FREE RADICAL BIOLOGY AND MEDICINE

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

The discovery of nitro-fatty acids as products of metabolic and inflammatory reactions and mediators of adaptive cell signaling

(2018) Bruce A. Freeman et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Unsolved mysteries: How does lipid peroxidation cause ferroptosis?

(2018) Huizhong Feng et al.   PLOS BIOLOGY

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

P53-dependent induction of ferroptosis is required for artemether to alleviate carbon tetrachloride-induced liver fibrosis and hepatic stellate cell activation

(2018) Ling Wang et al.   IUBMB LIFE

The selective effect of glycyrrhizin and glycyrrhetinic acid on topoisomerase IIα and apoptosis in combination with etoposide on triple negative breast cancer MDA-MB-231 cells

(2017) Yun Cai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Iron and thiol redox signaling in cancer: An exquisite balance to escape ferroptosis

(2017) Shinya Toyokuni et al.   FREE RADICAL BIOLOGY AND MEDICINE

18β-glycyrrhetinic acid inhibits migration and invasion of human gastric cancer cells via the ROS/PKC-α/ERK pathway

(2017) Hongke Cai et al.   Journal of Natural Medicines

Ferroptosis and autophagy induced cell death occur independently after siramesine and lapatinib treatment in breast cancer cells

(2017) Shumei Ma et al.   PLoS One

Ferroptosis: process and function

(2016) Y Xie et al.   CELL DEATH AND DIFFERENTIATION

Ferroptosis is an autophagic cell death process

(2016) Minghui Gao et al.   CELL RESEARCH

Glycyrrhetinic Acid and Its Derivatives: Anti-Cancer and Cancer Chemopreventive Properties, Mechanisms of Action and Structure- Cytotoxic Activity Relationship

(2016) Ali Roohbakhsh et al.   CURRENT MEDICINAL CHEMISTRY

Glycyrrhetinic Acid Mediated Drug Delivery Carriers for Hepatocellular Carcinoma Therapy

(2016) Yuee Cai et al.   MOLECULAR PHARMACEUTICS

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

A rationally designed rhodamine-based fluorescent probe for molecular imaging of peroxynitrite in live cells and tissues

(2016) Tao Peng et al.   Chemical Science

Glycyrrhetinic acid induces G1-phase cell cycle arrest in human non-small cell lung cancer cells through endoplasmic reticulum stress pathway

(2015) JIE ZHU et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cellular mechanisms and physiological consequences of redox-dependent signalling

(2014) Kira M. Holmström et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

18beta-Glycyrrhetinic acid induces apoptosis in pituitary adenoma cells via ROS/MAPKs-mediated pathway

(2013) Di Wang et al.   JOURNAL OF NEURO-ONCOLOGY

Modulation of oxidative stress as an anticancer strategy

(2013) Chiara Gorrini et al.   NATURE REVIEWS DRUG DISCOVERY

Glutathione peroxidases

(2012) Regina Brigelius-Flohé et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells

(2012) Tasuku Hirayama et al.   Chemical Science

18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells

(2011) Gunjan Sharma et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Inhibition of pituitary tumor-transforming gene-1 in thyroid cancer cells by drugs that decrease specificity proteins

(2011) Sudhakar Chintharlapalli et al.   MOLECULAR CARCINOGENESIS

Triple-Negative Breast Cancer

(2010) Steven J. Isakoff   CANCER JOURNAL

Oncogenic microRNA-27a is a target for anticancer agent methyl 2-cyano-3,11-dioxo-18β-olean-1,12-dien-30-oate in colon cancer cells

(2009) Sudhakar Chintharlapalli et al.   INTERNATIONAL JOURNAL OF CANCER

Induction of apoptosis and nonsteroidal anti-inflammatory drug-activated gene 1 in pancreatic cancer cells by a glycyrrhetinic acid derivative

(2009) Indira Jutooru et al.   MOLECULAR CARCINOGENESIS

Glutathione peroxidase family - an evolutionary overview

(2008) Rogerio Margis et al.   FEBS Journal

Effects of glycyrrhetinic acid and liquorice extract on cell proliferation and prostate-specific antigen secretion in LNCaP prostate cancer cells

(2008) Susan Hawthorne et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY