Journal
FOOD CHEMISTRY
Volume 349, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.foodchem.2021.129171
Keywords
Ratiometric fluorescence; Zearalenone; Mitoxantrone; Inner filter effect
Funding
- National Natural Science Foundation of China [22074055, 61801195]
- Innovation/Entrepreneurship Program of Jiangsu Province
- Natural Science Foundation of the Jiangsu Higher Education Institutions of China [18KJB416004]
- Priority Academic Program Development (PAPD) of Jiangsu Higher Education Institutions [PAPD-2018-87]
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An innovative ratiometric fluorescence aptasensor was developed for accurate analysis of ZEN in corn and barley flour. By using MTX as quencher and NGQDs-apt and CdTe QDs@SiO2 as ratiometric probes, the detection of ZEN was achieved with outstanding performance.
Herein, an innovative ratiometric fluorescence (FL) aptasensor was successfully fabricated for the accurate analysis of zearalenone (ZEN) in corn and barley flour. The ZEN aptamer-modified nitrogen doped graphene quantum dots (NGQDs-apt) and silica sphere-encapsulated cadmium telluride quantum dots (CdTe QDs@SiO2) were directly mixed and applied as ratiometric probes. In the absence of ZEN, mitoxantrone (MTX), which was innovatively introduced as quencher, was captured by NGQDs-apt and its inner filter effect (IFE) on CdTe QDs@SiO2 was inhibited. When ZEN existed, MTX separated from NGQDs-apt and re-dispersed around CdTe QDs@SiO2 owing to the competitive binding of ZEN with its aptamer. As the IFE of free MTX on CdTe QDs@SiO2 recovering, the FL intensity of CdTe QDs@SiO2 was quenched, while the FL intensity of NGQDs-apt was nearly invariant. On this basis, a ratiometric FL aptasensor for ZEN was fabricated, which exhibited outstanding detection performances with a desirable detection limit of 0.32 pg mL(-1).
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