A review of a new voltage-gated Ca2+ channel α2δ ligand, mirogabalin, for the treatment of peripheral neuropathic pain

Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects

(2021) Misa Oyama et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Switching From Pregabalin to Mirogabalin in Patients with Peripheral Neuropathic Pain: A Multi-Center, Prospective, Single-Arm, Open-Label Study (MIROP Study)

(2021) Yoshiyuki Kimura et al.   Pain and Therapy

Cross-sectional study of patient satisfaction with oral analgesics in patients with chronic pain in Japan

(2020) Takahiro Ushida et al.   EXPERT OPINION ON PHARMACOTHERAPY

Mirogabalin in Japanese Patients with Renal Impairment and Pain Associated with Diabetic Peripheral Neuropathy or Post-Herpetic Neuralgia: A Phase III, Open-Label, 14-Week Study

(2020) Masayuki Baba et al.   Journal of Pain Research

Long-term safety and efficacy of mirogabalin in Asian patients with postherpetic neuralgia

(2020) Jitsu Kato et al.   MEDICINE

Mirogabalin for the treatment of diabetic peripheral neuropathic pain: A randomized, double-blind, placebo-controlled phase III study in Asian patients

(2019) Masayuki Baba et al.   Journal of Diabetes Investigation

Mirogabalin for the management of postherpetic neuralgia

(2019) Jitsu Kato et al.   PAIN

Mirogabalin: First Global Approval

(2019) Emma D. Deeks   DRUGS

Recent prescription status of oral analgesics in Japan in real-world clinical settings: retrospective study using a large-scale prescription database

(2019) Takahiro Ushida et al.   EXPERT OPINION ON PHARMACOTHERAPY

Long‐term Safety and Efficacy of Mirogabalin in Asian Patients with Diabetic Peripheral Neuropathic Pain

(2019) Masayuki Baba et al.   Journal of Diabetes Investigation

Coadministration of Probenecid and Cimetidine with Mirogabalin in Healthy Subjects: A Phase 1, Randomized, Open-Label, Drug-Drug Interaction Study

(2018) Masaya Tachibana et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for theα2δSubunit of Voltage-Gated Calcium Channels

(2018) Yuki Domon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A new look at painful diabetic neuropathy

(2018) Gordon Sloan et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pharmacokinetics and Safety of a Single Oral Dose of Mirogabalin in Japanese Subjects With Varying Degrees of Renal Impairment

(2017) Manabu Kato et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Topical Treatment of Peripheral Neuropathic Pain: Applying the Evidence

(2017) Claudia Sommer et al.   JOURNAL OF PAIN AND SYMPTOM MANAGEMENT

Neuropathic pain

(2017) Luana Colloca et al.   Nature Reviews Disease Primers

Increasing Incidence of Herpes Zoster Over a 60-year Period From a Population-based Study

(2016) Kosuke Kawai et al.   CLINICAL INFECTIOUS DISEASES

Humanistic and economic burden of painful diabetic peripheral neuropathy in Europe: A review of the literature

(2015) Cathelijne J.M. Alleman et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Suboptimal Treatment of Diabetic Peripheral Neuropathic Pain in the United States

(2015) Mei Yang et al.   PAIN MEDICINE

Chronic Pain in the Japanese Community—Prevalence, Characteristics and Impact on Quality of Life

(2015) Shinsuke Inoue et al.   PLoS One

Efficacy and Safety of Mirogabalin (DS-5565) for the Treatment of Diabetic Peripheral Neuropathic Pain: A Randomized, Double-Blind, Placebo- and Active Comparator–Controlled, Adaptive Proof-of-Concept Phase 2 Study

(2014) Aaron Vinik et al.   DIABETES CARE

Similar herpes zoster incidence across Europe: results from a systematic literature review

(2013) Sybil Pinchinat et al.   BMC INFECTIOUS DISEASES

Chronic Pain with Neuropathic Characteristics in Diabetic Patients: A French Cross-Sectional Study

(2013) Didier Bouhassira et al.   PLoS One

Targeting voltage-gated calcium channels: developments in peptide and small-molecule inhibitors for the treatment of neuropathic pain

(2012) S Vink et al.   BRITISH JOURNAL OF PHARMACOLOGY

Prevalence and Characteristics of Painful Diabetic Neuropathy in a Large Community-Based Diabetic Population in the U.K.

(2011) C. A. Abbott et al.   DIABETES CARE

Herpes Zoster and Postherpetic Neuralgia Surveillance Using Structured Electronic Data

(2011) Michael Klompas et al.   MAYO CLINIC PROCEEDINGS

Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states

(2011) Amin Boroujerdi et al.   PAIN

New Developments in the Treatment Algorithm for Peripheral Neuropathic Pain

(2011) Oscar de Leon-Casasola   PAIN MEDICINE

Diabetic painful and insensate neuropathy: Pathogenesis and potential treatments

(2009) Irina G. Obrosova   Neurotherapeutics

Mechanisms of analgesia by gabapentin and pregabalin – Calcium channel α2-δ [Cavα2-δ] ligands

(2009) Charles P. Taylor   PAIN