Mirogabalin activates the descending noradrenergic system by binding to the α2δ-1 subunit of voltage-gated Ca2+ channels to generate analgesic effects

Mirogabalin for the treatment of diabetic peripheral neuropathic pain: A randomized, double-blind, placebo-controlled phase III study in Asian patients

(2019) Masayuki Baba et al.   Journal of Diabetes Investigation

Mirogabalin for the management of postherpetic neuralgia

(2019) Jitsu Kato et al.   PAIN

Gabapentin prevents synaptogenesis between sensory and spinal cord neurons induced by thrombospondin-4 acting on pre-synaptic Cav α2 δ1 subunits and involving T-type Ca2+ channels

(2018) Yanhui Peter Yu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Binding Characteristics and Analgesic Effects of Mirogabalin, a Novel Ligand for theα2δSubunit of Voltage-Gated Calcium Channels

(2018) Yuki Domon et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The α2δ-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions

(2018) Jinjun Chen et al.   Cell Reports

Increased α2δ-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain

(2018) Youfang Chen et al.   JOURNAL OF NEUROCHEMISTRY

Central Mechanisms Mediating Thrombospondin-4-induced Pain States

(2016) John Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 2 -1 Gene Deletion Affects Somatosensory Neuron Function and Delays Mechanical Hypersensitivity in Response to Peripheral Nerve Damage

(2013) R. Patel et al.   JOURNAL OF NEUROSCIENCE

Interventional management of neuropathic pain: NeuPSIG recommendations

(2013) Robert H. Dworkin et al.   PAIN

Thrombospondin-4 Contributes to Spinal Sensitization and Neuropathic Pain States

(2012) D.-S. Kim et al.   JOURNAL OF NEUROSCIENCE

α2δ expression sets presynaptic calcium channel abundance and release probability

(2012) Michael B. Hoppa et al.   NATURE

Pharmacological characterization of lysophosphatidic acid-induced pain with clinically relevant neuropathic pain drugs

(2011) K. Ogawa et al.   EUROPEAN JOURNAL OF PAIN

The Increased Trafficking of the Calcium Channel Subunit  2 -1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the  2  Ligand Pregabalin

(2009) C. S. Bauer et al.   JOURNAL OF NEUROSCIENCE

Gabapentin produces PKA-dependent pre-synaptic inhibition of GABAergic synaptic transmission in LC neurons following partial nerve injury in mice

(2008) Keiko Takasu et al.   JOURNAL OF NEUROCHEMISTRY

Pain relief by gabapentin and pregabalin via supraspinal mechanisms after peripheral nerve injury

(2008) Mitsuo Tanabe et al.   JOURNAL OF NEUROSCIENCE RESEARCH