Review
Medicine, General & Internal
Kunal Ramesh Chandekar, Arun Prashanth, Sobhan Vinjamuri, Rakesh Kumar
Summary: Despite limitations in specificity and sensitivity, Positron Emission Tomography (PET) using [F-18]Fluorodeoxyglucose (FDG) has revolutionized oncological imaging. Fibroblast activation protein (FAP), expressed by cancer-associated fibroblasts (CAFs), shows promise as a pan-cancer target. Radiolabeled FAP inhibitors (FAPI) have been developed for molecular imaging and theranostic applications, with encouraging preliminary data on FAPI PET/CT and ongoing clinical research. This review summarizes the literature on FAPI PET/CT imaging, focusing on diagnostic applications, comparison with FDG, pitfalls, and future directions.
Article
Radiology, Nuclear Medicine & Medical Imaging
Guokun Wang, Qinqin Yang, Shengyong Wu, Xudong Xu, Xiao Li, Siyu Liang, Guixia Pan, Changjing Zuo, Xianxian Zhao, Chao Cheng, Suxuan Liu
Summary: [(68) Ga]Ga-FAPI-04 PET/CT can monitor early cardiac fibrosis in pressure overload heart failure and predict the deterioration of cardiac function.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Halil Komek, Canan Can, Ihsan Kaplan, Cihan Gundogan, Ferat Kepenek, Huseyin Karaoglan, Aykut Demirkiran, Senar Ebinc, Yunus Guzel, Ebubekir Gundes
Summary: [(68) Ga]Ga-DOTA-FAPI-04 PET/CT demonstrates higher sensitivity and specificity in the evaluation of primary lesions and metastases in patients with colorectal cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Ihsan Kaplan, Canan Can, Yunus Guzel, Ulas Alabalik, Halil Komek
Summary: F-18-FDG PET/CT and Ga-68-FAPI 04 PET/CT were used for restaging in a 16-year-old boy with malignant mixed germ cell tumor. Results showed that Ga-68-FAPI-04 PET/CT was superior to F-18-FDG PET/CT in the evaluation of metastases in the testicular tumor.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jana Kupusovic, Lukas Kessler, Stephan G. Nekolla, Lisa Riesinger, Manuel M. Weber, Justin Ferdinandus, Simon Kochhaeuser, Tienush Rassaf, Reza Wakili, Christoph Rischpler, Johannes Siebermair
Summary: The purpose of the study was to assess (68) Ga-fibroblast-activation protein inhibitor (FAPI) uptake in the pulmonary vein region after pulmonary vein isolation (PVI) with cryoballoon ablation (CBA) and radiofrequency (RFA). The results showed higher FAPI uptake in PVs in PVI patients compared to controls, and CBA seemed to cause more pronounced fibroblast activation following tissue injury than RFA. Future studies are needed to further understand the mechanisms of AF recurrence after PVI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ruohua Chen, Xinlan Yang, Xiaofeng Yu, Xiang Zhou, Yee Ling Ng, Yumei Chen, Lianghua Li, Yun Zhou, Gang Huang, Jianjun Liu
Summary: Ultra-early and fast imaging showed equivalent tumor detection and lesion uptake compared to traditional [(68) Ga]Ga-FAPI-04 imaging. This method could meet clinical diagnostic requirements for patients with intolerance to prolonged horizontal positioning and waiting time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Caner Civan, Serkan Kuyumcu, Duygu Has Simsek, Oner Sanli, Emine Goknur Isik, Zeynep Gozde Ozkan, Ozge Hurdogan, Yasemin Sanli
Summary: This study investigates the role of [Ga-68]Ga-FAPI-04 PET/CT in patients with renal cell carcinoma (RCC) and demonstrates its potential utility in providing valuable information for the diagnosis and prognosis of RCC. The results suggest that [Ga-68]Ga-FAPI-04 PET/CT may have promising applications in selected patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xin Zhou, Shuailiang Wang, Xiaoxia Xu, Xiangxi Meng, Huiyuan Zhang, Annan Zhang, Yufei Song, Hua Zhu, Zhi Yang, Nan Li
Summary: This study compared the clinical staging performance of [(68) Ga]Ga-DOTA-FAPI-04 PET/CT and 2-[F-18]FDG PET/CT in non-small cell lung cancer (NSCLC) patients. The results showed that [(68) Ga]Ga-DOTA-FAPI-04 PET/CT had better staging performance in NSCLC patients, especially in localized disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tingting Xu, Haoyuan Ding, Dongmei Fan, Qingxue Shu, Guangfu Liu, Shumao Zhang, Yue Chen
Summary: This study aimed to explore the imaging value of Ga-68-FAPI-04 PET/CT in SAPHO syndrome and compare it with Tc-99m-MDP bone scan. The study found that Ga-68-FAPI-04 PET/CT had a higher detection rate for osteoarticular lesions and could also detect cases of synovitis. Therefore, Ga-68-FAPI-04 PET/CT may be a good imaging method for SAPHO syndrome, but further verification is needed in a more extensive research cohort.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yael Eshet, Noam Tau, Keren Levanon, Rinat Bernstein-Molho, Ofer Globus, Amit Itay, Tal Shapira, Cecilie Oedegaard, Michal Eifer, Tima Davidson, Meital Nidam, Einav Gal-Yam, Liran Domachevsky
Summary: This study investigated the use of 68Ga-fibroblast activation protein inhibitor (FAPI) PET/CT for response assessment and follow-up in patients with invasive lobular breast cancer (ILC). The results showed a strong correlation between 68Ga-FAPI tumor volume and blood tumor biomarkers, suggesting the potential of 68Ga-FAPI PET/CT for disease evaluation and monitoring.
CLINICAL NUCLEAR MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Weiwei Ruan, Chunxia Qin, Fang Liu, Rundong Pi, Yongkang Gai, Qingyao Liu, Xiaoli Lan
Summary: This study aimed to evaluate the potential of Q.Clear PET reconstruction in reducing tracer injection dose or scanning time in (68)Ga-FAPI PET/MR imaging. They collected retrospective cases of (68)Ga-FAPI whole-body imaging and compared three reconstruction methods: OSEM reconstruction with full scanning time, OSEM reconstruction with half scanning time, and Q.Clear reconstruction with half scanning time. The study found that Q.Clear reconstruction significantly increased SUVmax and SUVmean within lesions, reduced their volumes, and maintained image quality.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaomei Gao, Yongxiang Tang, Minfeng Chen, Jian Li, Hongling Yin, Yu Gan, Xiongbin Zu, Yi Cai, Shuo Hu
Summary: This study compared [Ga-68]Ga-RM26 PET/CT and [Ga-68]Ga-PSMA-617 PET/CT for diagnosing prostate cancer, and found that [Ga-68]Ga-PSMA-617 PET/CT had superior accuracy in detecting clinically significant PCa, while [Ga-68]Ga-RM26 PET/CT showed an advantage for imaging low-risk PCa.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zijun Chen, Yining Wang, Xinlan Yang, Lianghua Li, Yanmiao Huo, Xiaofeng Yu, Xiuying Xiao, Chenpeng Zhang, Yumei Chen, Haitao Zhao, Yun Zhou, Gang Huang, Jianjun Liu, Ruohua Chen
Summary: This study aimed to explore the effect of half-dose [Ga-68]Ga-FAPI-04 on image quality and tumor detectability in oncology patients. The results showed that with a reduced acquisition time of 120 s, half-dose [Ga-68]Ga-FAPI-04 in total-body PET/CT imaging achieved acceptable subjective image quality and 100% tumor detection rate.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingxin Gu, Xin Liu, Shuoer Wang, Xiaoping Xu, Xiaosheng Liu, Silong Hu, Wangjun Yan, Zhiguo Luo, Shaoli Song
Summary: This study evaluated the diagnostic value of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT for recurrent soft tissue sarcoma (STS) and compared it with [F-18]FDG PET/CT. The results showed that [(68)Ga]Ga-DOTA-FAPI-04 PET/CT was more accurate than [F-18]FDG PET/CT in detecting recurrent lesions of liposarcoma, MSFT, and IDCS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Manuel Roehrich, Patrick Naumann, Frederik L. Giesel, Peter L. Choyke, Fabian Staudinger, Annika Wefers, Dawn P. Liew, Clemens Kratochwil, Hendrik Rathke, Jakob Liermann, Klaus Herfarth, Dirk Jaeger, Juergen Debus, Uwe Haberkorn, Matthias Lang, Stefan A. Koerber
Summary: The use of Ga-68-FAPI PET/CT imaging in PDAC patients led to significant changes in TNM staging and impacted the management of some patients.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Katharina Dendl, Stefan A. Koerber, Sebastian Adeberg, Manuel Roehrich, Clemens Kratochwil, Uwe Haberkorn, Frederik L. Giesel
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Chemistry, Inorganic & Nuclear
Carolina Giammei, Nedra Jouini, Marie R. Brandt, Stefanie Frey, Thomas L. Mindt, Jens Cardinale
Summary: During multiple indium-111 labeling of DOTA-modified peptides from a single batch of [In-111]InCl3, inconsistent radiochemical yields were observed due to the formation of a radioactive impurity. This unknown In-111 species could be successfully suppressed by increasing the concentration of chloride ions in the stock solution, resulting in acceptable radiochemical yields. Additionally, convenient iTLC systems were reported for distinguishing between different species during radiolabeling.
APPLIED RADIATION AND ISOTOPES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Patrick Conen, Francesca Pennetta, Katharina Dendl, Fabian Hertel, Andreas Vogg, Uwe Haberkorn, Frederik L. Giesel, Felix M. Mottaghy
Summary: In this retrospective study, the diagnostic value of three different radiotracers for the noninvasive prediction of kidney fibrosis was analyzed. The results showed a significant negative correlation between renal parenchymal [(68) Ga]Ga-FAPI uptake and glomerular filtration rate (GFR), highlighting the potential value of [(68) Ga]Ga-FAPI for the noninvasive evaluation of kidney fibrosis.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Review
Oncology
Katharina Dendl, Stefan A. Koerber, Clemens Kratochwil, Jens Cardinale, Rebecca Finck, Mardjan Dabir, Emil Novruzov, Tadashi Watabe, Vasko Kramer, Peter L. Choyke, Uwe Haberkorn, Frederik L. Giesel
Summary: FAPI is a novel class of radiotracers that show promising results in imaging malignancies, while also being applicable to benign indications. FAP is overexpressed in many tumors and non-oncological conditions, suggesting potential for diagnostic and therapeutic applications in a variety of diseases.
Article
Chemistry, Medicinal
Nedra Jouini, Jens Cardinale, Thomas L. Mindt
Summary: The interaction between PD-1 and PD-L1 affects T-cell deactivation and cancer proliferation. Radiotracers provide information on the expression of PD-L1, allowing personalized treatment. This study aimed to develop a PD-L1-specific PET radiotracer but found that the previous peptide was not suitable.
Article
Behavioral Sciences
Susanne Nikolaus, Hans-Jorg Wittsack, Markus Beu, Hubertus Hautzel, Christina Antke, Eduards Mamlins, Jens Cardinale, Cvetana Decheva, Joseph P. Huston, Gerald Antoch, Frederik L. Giesel, Hans-Wilhelm Mueller
Summary: In this study, the effects of the 5-HT1A receptor antagonist, WAY-100635, on the dopaminergic system in the rat brain were assessed. It was found that WAY-100635 reduced D2/3R binding and resulted in decreased motor activity and increased grooming behavior. These effects were region-specific and time-dependent.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Katharina Dendl, Stefan A. Koerber, Katharina Tamburini, Yuriko Mori, Jens Cardinale, Uwe Haberkorn, Frederik L. Giesel
Summary: Fibroblast activation protein (FAP) is widely present in healthy tissue and upregulated in neoplastic tissue, including gynecological tumors. FAP expression can also be influenced by benign conditions. FAPI-PET/CT may be a promising tool for staging, restaging, and therapeutic management of gynecological cancers.
SEMINARS IN NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tadashi Watabe, Kazuko Kaneda-Nakashima, Yoshifumi Shirakami, Yuichiro Kadonaga, Kazuhiro Ooe, Yang Wang, Hiromitsu Haba, Atsushi Toyoshima, Jens Cardinale, Frederik L. Giesel, Noriyuki Tomiyama, Koichi Fukase
Summary: This study evaluated the treatment effect of At-211-labeled PSMA compounds in mouse xenograft models. The results showed that TAT using [At-211]PSMA5 resulted in excellent tumor growth suppression with minimal side effects, suggesting it as a potential new treatment for metastatic CRPC.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
E. Mamlins, D. Schmitt, M. Beu, K. Mattes-Gyoergy, J. M. Henke, C. Antke, E. Novruzov, J. Cardinale, J. Kirchner, G. Niegisch, J. P. Radtke, L. Schimmoeller, P. Albers, G. Antoch, F. L. Giesel
Summary: This retrospective study aimed to investigate the uptake of [F-18]PSMA-1007 in ganglia of the sympathetic trunk and its intra-individual reproducibility. The results showed a good intra-individual reproducibility of [F-18]PSMA-1007 uptake in ganglia, which can help differentiate them from possible malignant lesions.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yuriko Mori, Katharina Dendl, Jens Cardinale, Clemens Kratochwil, Frederik L. Giesel, Uwe Haberkorn
Summary: Gallium 68 (68Ga)-labeled fibroblast activation protein (FAP) inhibitor (FAPI) PET is a molecular imaging method that targets FAP, which is highly expressed in cancer-associated fibroblasts in the tumor stroma. Among various FAP-targeted radiopharmaceuticals, 68Ga-FAPI shows excellent imaging features with rapid tracer accumulation in target lesions and low background signal. It can detect small primary or metastatic lesions, especially in the brain, liver, pancreas, and gastrointestinal tract. Moreover, it can be used for theranostic applications by coupling with therapeutic emitters such as yttrium-90 using the DOTA chelator in its molecular structure.
Article
Radiology, Nuclear Medicine & Medical Imaging
Jens Cardinale, Frederik L. Giesel, Christina Wensky, Hendrik G. Rathke, Uwe Haberkorn, Clemens Kratochwil
Summary: In this study, a PSMA-targeted theranostic tandem with 99mTc/188Re was developed. The ligand PSMA-GCK01 demonstrated efficient radiolabeling with both radionuclides and comparable uptake characteristics to other ligands in cell-based assays. Animal experiments and clinical trials further confirmed the feasibility of this theranostic tandem.
JOURNAL OF NUCLEAR MEDICINE
(2023)