Article
Rheumatology
Samantha Cooray, Ebun Omyinmi, Ying Hong, Charalampia Papadopoulou, Lorraine Harper, Eslam Al-Abadi, Ruchika Goel, Shirish Dubey, Mark Wood, Stephen Jolles, Stefan Berg, Maria Ekelund, Kate Armon, Despina Eleftheriou, Paul A. Brogan
Summary: Anti-TNF treatment significantly reduced the incidence of ischaemic events and other vasculitic manifestations of DADA2, but was not effective for immunodeficiency or bone marrow failure.
Article
Cell Biology
Giulia Accardi, Filippa Bono, Giuseppe Cammarata, Anna Aiello, Maria Trinidad Herrero, Riccardo Alessandro, Giuseppa Augello, Ciriaco Carru, Paolo Colomba, Maria Assunta Costa, Immaculata De Vivo, Mattia Emanuela Ligotti, Alessia Lo Curto, Rosa Passantino, Simona Taverna, Carmela Zizzo, Giovanni Duro, Calogero Caruso, Giuseppina Candore
Summary: This study found that the levels of four circulating miRNAs gradually increase with age, except for the ultra-centenarians who show levels comparable to young individuals. These miRNAs may serve as biomarkers of ageing and have diagnostic/prognostic relevance for age-related diseases.
Article
Clinical Neurology
Huihui Liu, Mengxing Wang, Xianglong Xiang, Yuesong Pan, Jiejie Li, Xia Meng, Hao Li, Zixiao Li, Jing Jing, Yongjun Wang
Summary: This study found that persistent high residual inflammatory risk (RIR) increased the risks of stroke recurrence, composite vascular events, mortality, and poor functional outcome in patients with acute ischemic stroke or transient ischemic attack.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Marie Vandestienne, Yujiao Zhang, Icia Santos-Zas, Rida Al-Rifai, Jeremie Joffre, Andreas Giraud, Ludivine Laurans, Bruno Esposito, Florence Pinet, Patrick Bruneval, Juliette Raffort, Fabien Lareyre, Jose Vilar, Amir Boufenzer, Lea Guyonnet, Coralie Guerin, Eric Clauser, Jean-Sebastien Silvestre, Sylvie Lang, Laurie Soulat-Dufour, Alain Tedgui, Ziad Mallat, Soraya Taleb, Alexandre Boissonnas, Marc Derive, Giulia Chinetti, Hafid Ait-Oufella
Summary: The study demonstrated that TREM-1 plays a crucial role in the pathophysiology of AAA and could be a potential therapeutic target for the disease in humans.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Cell Biology
Yustina M. Puspitasari, Stefano Ministrini, Lena Schwarz, Caroline Karch, Luca Liberale, Giovanni G. Camici
Summary: The improvements in healthcare services and quality of life are leading to a longer life expectancy, resulting in a larger population of elderly individuals who are more susceptible to age-related cardiovascular diseases. Inflammation has been recognized as a key factor in the pathogenesis of cardiovascular diseases, suggesting that inflamm-aging could potentially be a driver of age-related cardiovascular afflictions and a viable therapeutic target.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Chemistry, Medicinal
Damiano Rocchi, Cristina Blazquez-Barbadillo, Mariangela Agamennone, Antonio Laghezza, Paolo Tortorella, David Vicente-Zurdo, Noelia Rosales-Conrado, Paula Moyano, Javier del Pino, Juan F. Gonzalez, J. Carlos Menendez
Summary: Matrix metalloproteinases (MMPs) play a key role in neuroinflammatory events and brain damage associated with stroke. The study revealed a new compound with inhibitory effects on MMPs and potential neuroprotective activity against oxidative stress, providing a promising lead for future drug development. The compounds showed some selectivity for specific MMP enzymes and a noncompetitive inhibition mechanism was observed.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Mediha Becirovic-Agic, Upendra Chalise, Michael J. Daseke, Shelby Konfrst, Jeffrey D. Salomon, Paras K. Mishra, Merry L. Lindsey
Summary: MMP-9 plays a dual role in myocardial infarction wound healing by exacerbating inflammatory response and aiding in transition to reparative cells, as well as influencing neovascularization and scar formation. Targeting MMP-9 only for its detrimental actions is important for effective treatment strategies.
Review
Cell Biology
Mohammad Reza Zinatizadeh, Peyman Kheirandish Zarandi, Mohsen Ghiasi, Hamid Kooshki, Mozafar Mohammadi, Jafar Amani, Nima Rezaei
Summary: New findings suggest that targeting aging pathways can improve the treatment of COVID-19. Boosting the immune system with new therapies can help elderly individuals with comorbidities fight against severe forms of the virus.
AGEING RESEARCH REVIEWS
(2023)
Review
Immunology
Ruth Stephens, John R. Grainger, Craig J. Smith, Stuart M. Allan
Summary: Acute ischaemic and haemorrhagic stroke are significant contributors to disability and morbidity worldwide, and the myeloid arm of the immune system plays a critical role in the response to these strokes. This review summarizes the key alterations to myeloid immunity in acute ischaemic stroke, intracerebral haemorrhage, and subarachnoid haemorrhage, and evaluates their associations with real-world outcomes such as infection.
SEMINARS IN IMMUNOPATHOLOGY
(2023)
Review
Cell Biology
Irene Maeve Rea, H. Denis Alexander
Summary: Covid-19 has had a significant impact on human life, with varying degrees of symptoms in different individuals. Older people and those with comorbidities such as diabetes, heart disease, and obesity are more likely to develop severe symptoms. Enhancing the immune function in older and frail individuals to prevent serious Covid-19 infection is a key consideration.
AGEING RESEARCH REVIEWS
(2022)
Article
Clinical Neurology
Bernadette Kirzinger, Andrea Stroux, Torsten Rackoll, Matthias Endres, Agnes Floeel, Martin Ebinger, Alexander Heinrich Nave
Summary: Elevated levels of IL-6 and fibrinogen in early subacute stroke were associated with worse outcomes up to 6 months post-stroke. However, exposure to aerobic physical fitness training did not alter the dynamics of inflammatory markers over time.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rita Favas, Janaina Morone, Rosario Martins, Vitor Vasconcelos, Graciliana Lopes
Summary: Skin, as the largest organ in the human body, acts as a physicochemical barrier protecting against environmental stressors and plays a significant psychosocial role in the aging population. The cosmetic industry is developing new formulas to reduce visible signs of aging prompted by consumer demands for skincare. Increasing importance is placed on natural products, with cyanobacteria and microalgae gaining importance for their anti-aging potential and effects on enzymes involved in pigmentation processes.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Review
Neurosciences
Hongmin Li, Samira Ghorbani, Chang Chun Ling, V. Wee Yong, Mengzhou Xue
Summary: Stroke is a major cause of death worldwide, with two subtypes: ischemic stroke and hemorrhagic stroke. Neuroinflammation plays a significant role in brain injury and repair after stroke, and is closely linked to the extracellular matrix (ECM). Different components of the ECM have distinct effects on stroke, contributing to both injury and recovery.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Immunology
Qiaohui Zhang, Yan Liao, Zhenquan Liu, Yajie Dai, Yunxin Li, Yue Li, Yibo Tang
Summary: The IL-17 family plays a crucial role in ischemic stroke, promoting inflammatory response and inducing secondary injury, exacerbating the disease progression.
Review
Biology
Rashi Agrawal, Anne Hu, Wendy B. Bollag
Summary: Aging affects the function of all cells in the body, including the skin, and leads to chronic low-level inflammation throughout the body. This inflamm-aging is thought to be caused by immune system malfunction and other age-related alterations. Skin, as the largest organ, plays a crucial role in barrier function and inflammation. Poorly functioning skin barrier may contribute to inflamm-aging.
Review
Cardiac & Cardiovascular Systems
Mariann Gyongyosi, Pilar Alcaide, Folkert W. Asselbergs, Bianca J. J. M. Brundel, Giovanni G. Camici, Paula da Costa Martins, Peter Ferdinandy, Marianna Fontana, Henrique Girao, Massimiliano Gnecchi, Can Gollmann-Tepekoylu, Petra Kleinbongard, Thomas Krieg, Rosalinda Madonna, Melanie Paillard, Antonis Pantazis, Cinzia Perrino, Maurizio Pesce, Gabriele G. Schiattarella, Joost P. G. Sluijter, Sabine Steffens, Carsten Tschope, Sophie Van Linthout, Sean M. Davidson
Summary: Long COVID is a global non-communicable epidemic characterized by long-lasting multiorgan symptoms after SARS-CoV-2 infection has subsided. This scientific document aims to provide insight into the cardiovascular manifestations of long COVID and the possible causes and therapeutic options available. Imaging has shown evidence of chronic perimyocarditis, arterial wall inflammation, and microthrombosis in certain patient populations. Understanding the underlying cellular and molecular mechanisms is crucial for the development of effective treatment strategies. However, current biomarkers are not highly predictive for the presence or outcome of long COVID.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Simon Kraler, Yustina M. Puspitasari, Nicole R. Bonetti, Alexander Akhmedov, Stefano Ministrini, Fabrizio Montecucco, Nikolaus Marx, Michael Lehrke, Niels Ulrik K. Hartmann, Jurg H. Beer, Florian A. Wenzl, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici
Summary: The study showed that SGLT-2 inhibition by empagliflozin does not impact experimental arterial thrombus formation, neither under baseline conditions nor during sustained low-grade inflammation. The results suggest that the beneficial effects of empagliflozin are likely independent of pathways mediating arterial thrombosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sylvia Haas, John A. Camm, Darius Harald, Jan Steffel, Saverio Virdone, Karen Pieper, Marianne Brodmann, Sebastian Schellong, Frank Misselwitz, Gloria Kayani, Ajay K. Kakkar
Summary: There are similarities and dissimilarities in AF management and clinical outcomes between DACH and ORW regions. The increased use of NOACs in DACH is associated with a mismatch in risk-adapted anticoagulation. Suboptimal control of INR is observed in both regions. DACH region has higher rates of cardiovascular death and lower rates of non-haemorrhagic stroke.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Yustina M. Puspitasari, Stefano Ministrini, Alexander Akhmedov, Simon Kraler, Nicole R. Bonetti, Georgia Beer, Ana Vukolic, Dario Bongiovanni, Jiaying Han, Kilian Kirmes, Isabell Bernlochner, Jaroslav Pelisek, Jurg H. Beer, Zheng-Gen Jin, Daniela Pedicino, Giovanna Liuzzo, Konstantinos Stellos, Fabrizio Montecucco, Filippo Crea, Thomas F. Luscher, Giovanni G. Camici
Summary: JCAD promotes arterial thrombosis by modulating coagulation and fibrinolysis. Knockout of JCAD reduces thrombogenicity in mice, and silencing of JCAD inhibits the expression of coagulation factors and fibrinolysis factors. These findings suggest JCAD as a potential therapeutic target for atherothrombosis.
EUROPEAN HEART JOURNAL
(2023)
Article
Endocrinology & Metabolism
Florian A. Wenzl, Alessandro Mengozzi, Shafeeq A. Mohammed, Nicola Riccardo Pugliese, Alessia Mongelli, Era Gorica, Samuele Ambrosini, Peter Riederer, Peter Fischer, Margareta Hinterberger, Yustina Puspitasari, Thomas F. Luscher, Giovanni G. Camici, Christian M. Matter, Gian Paolo Fadini, Agostino Virdis, Stefano Masi, Frank Ruschitzka, Edna Grunblatt, Francesco Paneni, Sarah Costantino
Summary: This study investigated the association between circulating long noncoding RNAs (lncRNAs) and incident type 2 diabetes in older adults. The researchers found that four lncRNAs (ANRIL, MIAT, RNCR3, and PLUTO) were associated with the development of type 2 diabetes and were linked to hemoglobin A(1c) levels throughout the 7.5-year follow-up period.
Letter
Endocrinology & Metabolism
Subodh Verma, Mansoor Husain, Christian M. Madsen, Lawrence A. Leiter, Anja Birk Kuhlman, Tina Vilsboll, Soren Rasmussen, Peter Libby
DIABETES OBESITY & METABOLISM
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Aeron M. Small, Peter Libby
EUROPEAN HEART JOURNAL
(2023)
Review
Cardiac & Cardiovascular Systems
Federico Carbone, Luca Liberale, Peter Libby, Fabrizio Montecucco
Summary: Experimental and clinical findings linking vitamin D to cardiovascular risk have prompted consideration of its supplementation for overall health improvement. However, several meta-analyses do not support its clinical effectiveness, and recent research has revealed complex non-classical effects of vitamin D in cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Kraler, Florian A. Wenzl, Jody Vykoukal, Johannes F. Fahrmann, Ming-Yi Shen, Der-Yuan Chen, Kuan-Cheng Chang, Ching-Kun Chang, Arnold von Eckardstein, Lorenz Raber, Francois Mach, David Nanchen, Christian M. Matter, Luca Liberale, Giovanni G. Camici, Alexander Akhmedov, Chu-Huang Chen, Thomas F. Luscher
Summary: Changes in LDL electronegativity are associated with adverse outcomes in patients with ACS, including increased all-cause and cardiovascular mortality. The LDL lipidome is also affected by these alterations, and specific lipid species are independently associated with fatal events.
Article
Cardiac & Cardiovascular Systems
Teresa Gerhardt, Claudio Seppelt, Youssef S. Abdelwahed, Denitsa Meteva, Christopher Wolfram, Philip Stapmanns, Aslihan Erbay, Lukas Zanders, Gregor Nelles, Johanna Musfeld, Lara Sieronski, Barbara E. Staehli, Rocco A. Montone, Rocco Vergallo, Arash Haghikia, Carsten Skurk, Fabian Knebel, Henryk Dreger, Tobias D. Trippel, Himanshu Rai, Michael Joner, Jens Klotsche, Peter Libby, Filippo Crea, Nicolle Kraenkel, Ulf Landmesser, David M. Leistner
Summary: This study investigates the clinical outcomes and inflammatory response in patients with acute coronary syndromes (ACS) caused by different mechanisms of plaque disruption. It found that patients with erosion of an intact fibrous cap (IFC-ACS) have a lower risk of major adverse cardiovascular events (MACE(+)) and a distinct inflammatory response compared to those with rupture of the fibrous cap (RFC-ACS). These findings provide hypothesis generating data for personalized anti-inflammatory therapeutic allocation in ACS patients.
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Yustina M. Puspitasari
EUROPEAN HEART JOURNAL
(2023)
Review
Cell Biology
Meret Sarah Allemann, Pratintip Lee, Jurg H. Beer, Seyed Soheil Saeedi Saravi
Summary: Cardiovascular aging poses a significant challenge and requires innovative strategies to restore aging cardiovascular tissues. Targeting the redox machinery holds promise to optimize cardiovascular regenerative therapies by enhancing stem cell function and rejuvenating cardiovascular tissues.
Article
Medicine, General & Internal
Annina Stauber, Andreas Mueller, Nikki Rommers, Stefanie Aeschbacher, Nicolas Rodondi, Leo H. Bonati, Juerg H. Beer, Raban V. Jeger, David J. Kurz, Claudia Liedtke, Peter Ammann, Marcello Di Valentino, Patricia Chocano, Richard Kobza, Michael Kuhne, David Conen, Stefan Osswald, Alain M. Bernheim
Summary: This study found that chocolate consumption was not associated with vascular brain lesions and major adverse cardiac events in patients with atrial fibrillation. However, low chocolate consumption was associated with lower cognitive scores, higher risk of heart failure hospitalization, and increased all-cause mortality.
SWISS MEDICAL WEEKLY
(2023)