Neuraminidase 1 is a driver of experimental cardiac hypertrophy

Reappraising the role of inflammation in heart failure

(2020) Luigi Adamo et al.   Nature Reviews Cardiology

Neuraminidase-1 promotes heart failure after ischemia/reperfusion injury by affecting cardiomyocytes and invading monocytes/macrophages

(2020) Maren Heimerl et al.   BASIC RESEARCH IN CARDIOLOGY

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

Influenza Virus Neuraminidase Structure and Functions

(2019) Julie L. McAuley et al.   Frontiers in Microbiology

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

(2019) Mark J. Ranek et al.   NATURE

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenzaa

(2019) Timothy M Uyeki et al.   CLINICAL INFECTIOUS DISEASES

Mechanisms of physiological and pathological cardiac hypertrophy

(2018) Michinari Nakamura et al.   Nature Reviews Cardiology

A positive feedback loop between IL-1β, LPS and NEU1 may promote atherosclerosis by enhancing a pro-inflammatory state in monocytes and macrophages

(2018) Irina Sieve et al.   VASCULAR PHARMACOLOGY

Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice

(2018) Elizabeth J. White et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

Bone Marrow-Derived Tenascin-C Attenuates Cardiac Hypertrophy by Controlling Inflammation

(2017) Lei Song et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Mononuclear Phagocytes Are Dispensable for Cardiac Remodeling in Established Pressure-Overload Heart Failure

(2017) Bindiya Patel et al.   PLoS One

Functional Metabolomics Characterizes a Key Role for N -Acetylneuraminic Acid in Coronary Artery Diseases

(2017) Lei Zhang et al.   CIRCULATION

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

(2016) Piotr Ponikowski et al.   EUROPEAN HEART JOURNAL

Inhibition of Hypertrophy Is a Good Therapeutic Strategy in Ventricular Pressure Overload

(2015) G. G. Schiattarella et al.   CIRCULATION

Phosphodiesterase 9A controls nitric-oxide-independent cGMP and hypertrophic heart disease

(2015) Dong I. Lee et al.   NATURE

A long noncoding RNA protects the heart from pathological hypertrophy

(2014) Pei Han et al.   NATURE

Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells

(2013) Feng Lan et al.   Cell Stem Cell

Positive Regulation of Insulin Signaling by Neuraminidase 1

(2013) L. Dridi et al.   DIABETES

Mammalian sialidases: Physiological and pathological roles in cellular functions

(2012) T. Miyagi et al.   GLYCOBIOLOGY

NEU1 Sialidase Expressed in Human Airway Epithelia Regulates Epidermal Growth Factor Receptor (EGFR) and MUC1 Protein Signaling

(2012) Erik P. Lillehoj et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypomorphic sialidase expression decreases serum cholesterol by downregulation of VLDL production in mice

(2012) Abraham Yang et al.   JOURNAL OF LIPID RESEARCH

Hypertrophic cardiomyopathy

(2012) Barry J Maron et al.   LANCET

Neu1 desialylation of sialyl α-2,3-linked β-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling

(2009) Schammim Ray Amith et al.   CELLULAR SIGNALLING

Regulation of Phagocytosis in Macrophages by Neuraminidase 1

(2009) Volkan Seyrantepe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuraminidase-1, a Subunit of the Cell Surface Elastin Receptor, Desialylates and Functionally Inactivates Adjacent Receptors Interacting with the Mitogenic Growth Factors PDGF-BB and IGF-2

(2008) Aleksander Hinek et al.   AMERICAN JOURNAL OF PATHOLOGY

Serum response factor neutralizes Purα- and Purβ-mediated repression of the fetal vascular smooth muscle α-actin gene in stressed adult cardiomyocytes

(2008) Aiwen Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Molecular regulation of cardiac hypertrophy

(2008) Sean P. Barry et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY