Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways
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Title
Mechanistic insight into toxicity of phthalates, the involved receptors, and the role of Nrf2, NF-κB, and PI3K/AKT signaling pathways
Authors
Keywords
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Journal
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Volume 28, Issue 27, Pages 35488-35527
Publisher
Springer Science and Business Media LLC
Online
2021-05-23
DOI
10.1007/s11356-021-14466-5
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- Dibutyl phthalate-induced neurotoxicity in the brain of immature and mature rat offspring
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- Lower concentrations of phthalates induce proliferation in human breast cancer cells
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- Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations
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- Effects of in Utero Exposure to Di(n-butyl) Phthalate for Estrogen Receptors α, β, and Androgen Receptor of Leydig Cell on Rats
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- Exposure to DEHP decreased four fatty acid levels in plasma of prepartum mice
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- Androgen receptor-mediated apoptosis in bovine testicular induced pluripotent stem cells in response to phthalate esters
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- Ablation of Vimentin Results in Defective Steroidogenesis
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- Phthalate Exposure Changes the Metabolic Profile of Cardiac Muscle Cells
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- The role of androgen-induced growth factor (FGF8) on genital tubercle development in a hypospadiac male rat model of prenatal exposure to di-n-butyl phthalate
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- Antiandrogenic activity of phthalate mixtures: Validity of concentration addition
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- Assay of vtg, ERs and PPARs as endpoint for the rapid in vitro screening of the harmful effect of Di-(2-ethylhexyl)-phthalate (DEHP) and phthalic acid (PA) in zebrafish primary hepatocyte cultures
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- Maternal exposure to di-(2-ethylhexyl)phthalate alters kidney development through the renin–angiotensin system in offspring
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- Biological impact of phthalates
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- Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium
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- In Utero Exposure to the Antiandrogen Di-(2-Ethylhexyl) Phthalate Decreases Adrenal Aldosterone Production in the Adult Rat1
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- Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase
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- Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current State of Art
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- Di-(2-ethylhexyl) phthalate induces production of inflammatory molecules in human macrophages
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- Spinal Phosphinositide 3-Kinase-Akt-Mammalian Target of Rapamycin Signaling Cascades in Inflammation-Induced Hyperalgesia
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- Identification of estrogenic genes responding to phthalate esters treatment in human MCF-7 cells
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- The Endocrine Disruptor Mono-(2-Ethylhexyl) Phthalate Affects the Differentiation of Human Liposarcoma Cells (SW 872)
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- Biomonitoring Equivalents for di-isononyl phthalate (DINP)
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- Benzyl butyl phthalate induces necrosis by AhR mediation of CYP1B1 expression in human granulosa cells
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- Selective Phthalate Activation of Naturally Occurring Human Constitutive Androstane Receptor Splice Variants and the Pregnane X Receptor
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- Prenatal exposure to di-n-butyl phthalate induces anorectal malformations in male rat offspring
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- Hepatic peroxisome proliferator-activated receptor α may have an important role in the toxic effects of di(2-ethylhexyl)phthalate on offspring of mice
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- Di (2-ethylhexyl) phthalate inhibits growth of mouse ovarian antral follicles through an oxidative stress pathway
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- The pesticide deltamethrin increases free radical production and promotes nuclear translocation of the stress response transcription factor Nrf2 in rat brain
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- Activation of Trim17 by PPARγ is involved in Di(2-ethylhexyl) phthalate (DEHP)-induced apoptosis on Neuro-2a cells
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- Mono-2-ethylhexylphthalate (MEHP) induces TNF-α release and macrophage differentiation through different signalling pathways in RAW264.7 cells
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- Regulation of drug-metabolizing enzymes by xenobiotic receptors: PXR and CAR
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- Targeting the PI3K signaling pathway in cancer
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- The Pollutant Diethylhexyl Phthalate Regulates Hepatic Energy Metabolism via Species-Specific PPARα-Dependent Mechanisms
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- Differential Effects of Flutamide and Di-(2-ethylhexyl) phthalate on Male Reproductive Organs in a Rat Model
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- Phthalates Impair Germ Cell Number in the Mouse Fetal Testis by an Androgen- and Estrogen-Independent Mechanism
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- Long-term effects of developmental exposure to di-n-butyl-phthalate (DBP) on rat prostate: Proliferative and inflammatory disorders and a possible role of androgens
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- Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach
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- Comparison of in vitro hormone activities of selected phthalates using reporter gene assays
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- Shared Principles in NF-κB Signaling
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