Cross-Model Comparison of Transcriptomic Dose–Response of Short-Chain Chlorinated Paraffins

Pathway-based assessment of single chemicals and mixtures by a high-throughput transcriptomics approach

(2020) Pu Xia et al.   ENVIRONMENT INTERNATIONAL

Single-Cell Sequencing Reveals Heterogeneity Effects of Bisphenol A on Zebrafish Embryonic Development

(2020) Ling Chen et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effect of short-chain chlorinated paraffins on metabolic profiling of male SD rats

(2020) Ningbo Geng et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A Set of Six Gene Expression Biomarkers and Their Thresholds Identify Rat Liver Tumorigens in Short-Term Assays

(2020) Robert W. Lewis et al.   TOXICOLOGY

De Novo Development of a Quantitative Adverse Outcome Pathway (qAOP) Network for Ultraviolet B (UVB) Radiation Using Targeted Laboratory Tests and Automated Data Mining

(2020) You Song et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Extracting and Benchmarking Emerging Adverse Outcome Pathway Knowledge

(2019) Nathan L Pollesch et al.   TOXICOLOGICAL SCIENCES

The chlorine contents and chain lengths influence the neurobehavioral effects of commercial chlorinated paraffins on zebrafish larvae

(2019) Xinyue Yang et al.   JOURNAL OF HAZARDOUS MATERIALS

Identification of potential endocrine disrupting chemicals using gene expression biomarkers

(2019) J. Christopher Corton et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Quantitative Response-Response Relationships Linking Aromatase Inhibition to Decreased Fecundity are Conserved Across Three Fishes with Asynchronous Oocyte Development

(2019) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor α (PPARα)

(2019) Yufeng Gong et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Integration of metabolomics and transcriptomics reveals short-chain chlorinated paraffin-induced hepatotoxicity in male Sprague-Dawley rat

(2019) Ningbo Geng et al.   ENVIRONMENT INTERNATIONAL

Common Gene Expression Patterns in Environmental Model Organisms Exposed to Engineered Nanomaterials: A Meta-Analysis

(2019) Michael Burkard et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Early Life Stage Bioactivity Assessment of Short-Chain Chlorinated Paraffins at Environmentally Relevant Concentrations by Concentration-Dependent Transcriptomic Analysis of Zebrafish Embryos

(2019) Ying Peng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The environmental distribution and toxicity of short-chain chlorinated paraffins and underlying mechanisms: Implications for further toxicological investigation

(2019) Xia Wang et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A Reduced Transcriptome Approach to Assess Environmental Toxicants Using Zebrafish Embryo Test

(2018) Pingping Wang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Omics Advances in Ecotoxicology

(2018) Xiaowei Zhang et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A Cross-species Quantitative Adverse Outcome Pathway for Activation of the Aryl Hydrocarbon Receptor Leading to Early Life Stage Mortality in Birds and Fishes

(2018) Jon A. Doering et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Adverse outcome pathway networks II: Network analytics

(2018) Daniel L. Villeneuve et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Adverse outcome pathway networks I: Development and applications

(2018) Dries Knapen et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Short-chain chlorinated paraffins (SCCPs) induced thyroid disruption by enhancement of hepatic thyroid hormone influx and degradation in male Sprague Dawley rats

(2018) Yufeng Gong et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Developmental and metabolic responses of zebrafish ( Danio rerio ) embryos and larvae to short-chain chlorinated paraffins (SCCPs) exposure

(2018) Xiaoqian Ren et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Introducing WikiPathways as a Data-Source to Support Adverse Outcome Pathways for Regulatory Risk Assessment of Chemicals and Nanomaterials

(2018) Marvin Martens et al.   Frontiers in Genetics

Benchmarking Water Quality from Wastewater to Drinking Waters Using Reduced Transcriptome of Human Cells

(2017) Pu Xia et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

A Data Fusion Pipeline for Generating and Enriching Adverse Outcome Pathway Descriptions

(2017) Penny Nymark et al.   TOXICOLOGICAL SCIENCES

Assessment of the endocrine-disrupting effects of short-chain chlorinated paraffins in in vitro models

(2016) Quan Zhang et al.   ENVIRONMENT INTERNATIONAL

Occurrence, fate and ecological risk of chlorinated paraffins in Asia: A review

(2016) Gao-Ling Wei et al.   ENVIRONMENT INTERNATIONAL

Analyzing and interpreting genome data at the network level with ConsensusPathDB

(2016) Ralf Herwig et al.   Nature Protocols

Editor’s Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity

(2016) Carlie A. LaLone et al.   TOXICOLOGICAL SCIENCES

Identification and Characterization of Androgen-Responsive Genes in Zebrafish Embryos

(2015) Eva Fetter et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Effects of Short-Chain Chlorinated Paraffins Exposure on the Viability and Metabolism of Human Hepatoma HepG2 Cells

(2015) Ningbo Geng et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

High-throughput concentration-response analysis for omics datasets

(2015) Soňa Smetanová et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Nano-risk Science: application of toxicogenomics in an adverse outcome pathway framework for risk assessment of multi-walled carbon nanotubes

(2015) Sarah Labib et al.   Particle and Fibre Toxicology

A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

(2015) Marja Driessen et al.   TOXICOLOGY LETTERS

Immunophilin FKBP52 induces Tau-P301L filamentous assembly in vitro and modulates its activity in a model of tauopathy

(2014) J. Giustiniani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in Zebrafish (Danio rerio)

(2013) Afonso C.D. Bainy et al.   AQUATIC TOXICOLOGY

Calculation of Physicochemical Properties for Short- and Medium-Chain Chlorinated Paraffins

(2013) Juliane Glüge et al.   JOURNAL OF PHYSICAL AND CHEMICAL REFERENCE DATA

Role of CAR and PXR in xenobiotic sensing and metabolism

(2012) Yue-Ming Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Cross-species Comparisons of Transcriptomic Alterations in Human and Rat Primary Hepatocytes Exposed to 2,3,7,8-Tetrachlorodibenzo-p-dioxin

(2012) Michael B. Black et al.   TOXICOLOGICAL SCIENCES

Conserved toxic responses across divergent phylogenetic lineages: a meta-analysis of the neurotoxic effects of RDX among multiple species using toxicogenomics

(2011) Natàlia Garcia-Reyero et al.   ECOTOXICOLOGY

Concentration–response concept in ecotoxicoproteomics: Effects of different phenanthrene concentrations to the zebrafish (Danio rerio) embryo proteome

(2011) Ulrike Gündel et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

REVIGO Summarizes and Visualizes Long Lists of Gene Ontology Terms

(2011) Fran Supek et al.   PLoS One

Adverse outcome pathways: A conceptual framework to support ecotoxicology research and risk assessment

(2010) Gerald T. Ankley et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY