Integrins and heparan sulfate proteoglycans on hepatic stellate cells (HSC) are novel receptors for HSC-derived exosomes

Fibrogenic Signaling Is Suppressed in Hepatic Stellate Cells through Targeting of Connective Tissue Growth Factor (CCN2) by Cellular or Exosomal MicroRNA-199a-5p

(2016) Li Chen et al.   AMERICAN JOURNAL OF PATHOLOGY

Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation via αv integrin interaction

(2016) Akiko Sugiyama et al.   JOURNAL OF GASTROENTEROLOGY

Antifibrotic Therapies: Where Are We Now?

(2016) Young Yoon et al.   SEMINARS IN LIVER DISEASE

Promising Therapy Candidates for Liver Fibrosis

(2016) Ping Wang et al.   Frontiers in Physiology

Suppression of fibrogenic signaling in hepatic stellate cells by Twist1-dependent microRNA-214 expression: Role of exosomes in horizontal transfer of Twist1

(2015) Li Chen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Hepatic Fibrosis: Emerging Therapies

(2015) Scott L. Friedman   DIGESTIVE DISEASES

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

The αvβ6Integrin Is Transferred Intercellularly via Exosomes

(2015) Carmine Fedele et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome Adherence and Internalization by Hepatic Stellate Cells Triggers Sphingosine 1-Phosphate-dependent Migration

(2015) Ruisi Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Exosomes mediate intercellular transfer of pro-fibrogenic connective tissue growth factor (CCN2) between hepatic stellate cells, the principal fibrotic cells in the liver

(2014) Alyssa Charrier et al.   SURGERY

Epigenetic regulation of connective tissue growth factor by MicroRNA-214 delivery in exosomes from mouse or human hepatic stellate cells

(2013) Li Chen et al.   HEPATOLOGY

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

(2013) Neil C Henderson et al.   NATURE MEDICINE

Cancer cell exosomes depend on cell-surface heparan sulfate proteoglycans for their internalization and functional activity

(2013) H. C. Christianson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of hepatic stellate cells by connective tissue growth factor

(2012) Guangcun Huang   Frontiers in Bioscience-Landmark

Role of integrins in fibrosing liver diseases

(2011) Eleonora Patsenker et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Osteopontin, an oxidant stress sensitive cytokine, up-regulates collagen-I via integrin αVβ3 engagement and PI3K/pAkt/NFκB signaling

(2011) Raquel Urtasun et al.   HEPATOLOGY

Heparan Sulfate Proteoglycans

(2011) S. Sarrazin et al.   Cold Spring Harbor Perspectives in Biology

Biochemical characterization of the binding of cyclic RGDyK to hepatic stellate cells

(2010) Xiao-wei Huang et al.   BIOCHEMICAL PHARMACOLOGY

Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living Cells

(2010) Nobuyoshi Kosaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosome release of β-catenin: a novel mechanism that antagonizes Wnt signaling

(2010) Arthit Chairoungdua et al.   JOURNAL OF CELL BIOLOGY

Integrin expression and function in the response of primary culture hepatic stellate cells to connective tissue growth factor (CCN2)

(2010) Guangcun Huang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Ethanol-stimulated differentiated functions of human or mouse hepatic stellate cells are mediated by connective tissue growth factor

(2010) Li Chen et al.   JOURNAL OF HEPATOLOGY

Heparan sulfate proteoglycans: structure, protein interactions and cell signaling

(2009) Juliana L. Dreyfuss et al.   ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS

Fibronectin Increases Survival of Rat Hepatic Stellate Cells - A Novel Profibrogenic Mechanism of Fibronectin

(2009) Cristina Rodríguez-Juan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Pharmacological inhibition of integrin αvβ3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis

(2009) Eleonora Patsenker et al.   HEPATOLOGY

Strategies for blocking the fibrogenic actions of connective tissue growth factor (CCN2): From pharmacological inhibition in vitro to targeted siRNA therapy in vivo

(2009) David R. Brigstock   Journal of Cell Communication and Signaling

Activated T cells recruit exosomes secreted by dendritic cells via LFA-1

(2008) E. N. M. Nolte-'t Hoen et al.   BLOOD

Mechanisms of Hepatic Fibrogenesis

(2008) Scott L. Friedman   GASTROENTEROLOGY

Hepatic fibrosis—Overview

(2008) Scott L. Friedman   TOXICOLOGY