Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat

In utero exposure to DBP stimulates release of GnRH by increasing the secretion of PGE2 in the astrocytes of the hypothalamus in the offspring mice

(2020) Yunhui Xia et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Bisphenol A induces Agrp gene expression in hypothalamic neurons through a mechanism involving ATF3.

(2020) Neruja Loganathan et al.   NEUROENDOCRINOLOGY

Metabolites of 4-methylbenzylidene camphor (4-MBC), butylated hydroxytoluene (BHT), and tris(2-ethylhexyl) trimellitate (TOTM) in urine of children and adolescents in Germany – human biomonitoring results of the German Environmental Survey GerES V (2014–2017)

(2020) Aline Murawski et al.   ENVIRONMENTAL RESEARCH

Exposure of Slovenian children and adolescents to bisphenols, parabens and triclosan: Urinary levels, exposure patterns, determinants of exposure and susceptibility

(2020) Žiga Tkalec et al.   ENVIRONMENT INTERNATIONAL

Cellular and molecular features of EDC exposure: consequences for the GnRH network

(2020) David Lopez-Rodriguez et al.   Nature Reviews Endocrinology

Maternal care modulates transgenerational effects of endocrine-disrupting chemicals on offspring pup vocalizations and adult behaviors

(2019) Krittika Krishnan et al.   HORMONES AND BEHAVIOR

The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads

(2019) Yang Liao et al.   NUCLEIC ACIDS RESEARCH

Environmentally Relevant Exposure to Dibutyl Phthalate Disrupts DNA Damage Repair Gene Expression in the Mouse Ovary

(2019) Xiaosong Liu et al.   BIOLOGY OF REPRODUCTION

Effects of in utero and lactational exposure to phthalates on reproductive development and glycemic homeostasis in rats

(2019) Amanda Caroline Venturelli et al.   TOXICOLOGY

Perinatal bisphenol A (BPA) exposure alters brain oxytocin receptor (OTR) expression in a sex- and region- specific manner: A CLARITY-BPA consortium follow-up study

(2019) Shannah K. Witchey et al.   NEUROTOXICOLOGY

Prenatal and ancestral exposure to di(2-ethylhexyl) phthalate alters gene expression and DNA methylation in mouse ovaries

(2019) Saniya Rattan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway

(2019) Pu Shao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice

(2019) Francisco Ruiz-Pino et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Maternal exposure to bisphenol A during pregnancy interferes ovaries development of F1 female mice

(2019) Yuanyuan Wei et al.   THERIOGENOLOGY

Role of the 17β-hydroxysteroid dehydrogenase signalling pathway in di-(2-ethylhexyl) phthalate-induced ovarian dysfunction: An in vivo study

(2019) Na Li et al.   SCIENCE OF THE TOTAL ENVIRONMENT

A Hypothalamic Midbrain Pathway Essential for Driving Maternal Behaviors

(2018) Yi-Ya Fang et al.   NEURON

Di(2-Ethylhexyl) Phthalate Exposure During Prenatal Development Causes Adverse Transgenerational Effects on Female Fertility in Mice

(2018) Saniya Rattan et al.   TOXICOLOGICAL SCIENCES

Trithorax dependent changes in chromatin landscape at enhancer and promoter regions drive female puberty

(2018) Carlos A. Toro et al.   Nature Communications

Role of Kisspeptin and Neurokinin B in Puberty in Female Non-Human Primates

(2018) Ei Terasawa et al.   Frontiers in Endocrinology

Vinclozolin induced epigenetic transgenerational inheritance of pathologies and sperm epimutation biomarkers for specific diseases

(2018) Eric Nilsson et al.   PLoS One

SIRT1 mediates obesity- and nutrient-dependent perturbation of pubertal timing by epigenetically controlling Kiss1 expression

(2018) M. J. Vazquez et al.   Nature Communications

Exposure to an Environmentally Relevant Phthalate Mixture Causes Transgenerational Effects on Female Reproduction in Mice

(2017) Changqing Zhou et al.   ENDOCRINOLOGY

Bisphenol A Exposure, Ovarian Follicle Numbers, and Female Sex Steroid Hormone Levels: Results From a CLARITY-BPA Study

(2017) Shreya Patel et al.   ENDOCRINOLOGY

Exposure to UV filters during summer and winter in Danish kindergarten children

(2017) Marianna Krause et al.   ENVIRONMENT INTERNATIONAL

Combined exposure to low doses of pesticides causes decreased birth weights in rats

(2017) Ulla Hass et al.   REPRODUCTIVE TOXICOLOGY

The effects of in utero bisphenol A exposure on ovarian follicle numbers and steroidogenesis in the F1 and F2 generations of mice

(2017) Sharada Mahalingam et al.   REPRODUCTIVE TOXICOLOGY

Metabolism disrupting chemicals and metabolic disorders

(2017) Jerrold J. Heindel et al.   REPRODUCTIVE TOXICOLOGY

Maternal exposure to di(2-ethylhexyl)phthalate (DEHP) promotes the transgenerational inheritance of adult-onset reproductive dysfunctions through the female germline in mice

(2017) Paola Pocar et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Bisphenol A Exposure Disrupts Neurotransmitters Through Modulation of Transaminase Activity in the Brain of Rodents

(2016) Daniel Zalko et al.   ENDOCRINOLOGY

Delayed Neuroendocrine Sexual Maturation in Female Rats After a Very Low Dose of Bisphenol A Through Altered GABAergic Neurotransmission and Opposing Effects of a High Dose

(2016) Delphine Franssen et al.   ENDOCRINOLOGY

Impact of Low Dose Oral Exposure to Bisphenol A (BPA) on the Neonatal Rat Hypothalamic and Hippocampal Transcriptome: A CLARITY-BPA Consortium Study

(2016) Sheryl E. Arambula et al.   ENDOCRINOLOGY

Multi- and transgenerational consequences of Bisphenol A on sexually dimorphic cell populations in mouse brain

(2016) Jessica A. Goldsby et al.   ENDOCRINOLOGY

Urinary concentrations of parabens and their association with demographic factors: A population-based cross-sectional study

(2016) Hui-Seung Kang et al.   ENVIRONMENTAL RESEARCH

Ovarian dysfunctions in adult female rat offspring born to mothers perinatally exposed to low doses of bisphenol A

(2016) Clarisa Santamaría et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Perinatal exposure to mixtures of endocrine disrupting chemicals reduces female rat follicle reserves and accelerates reproductive aging

(2016) Hanna Katarina Lilith Johansson et al.   REPRODUCTIVE TOXICOLOGY

The effects of in utero bisphenol A exposure on the ovaries in multiple generations of mice

(2016) Amelia Berger et al.   REPRODUCTIVE TOXICOLOGY

Analgesic exposure in pregnant rats affects fetal germ cell development with inter-generational reproductive consequences

(2016) Afshan Dean et al.   Scientific Reports

EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals

(2015) A. C. Gore et al.   ENDOCRINE REVIEWS

Acute Influences of Bisphenol A Exposure on Hypothalamic Release of Gonadotropin-Releasing Hormone and Kisspeptin in Female Rhesus Monkeys

(2015) Joseph R. Kurian et al.   ENDOCRINOLOGY

Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents

(2015) Anne-Simone Parent et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Selective optogenetic activation of arcuate kisspeptin neurons generates pulsatile luteinizing hormone secretion

(2015) Su Young Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mixtures of environmentally relevant endocrine disrupting chemicals affect mammary gland development in female and male rats

(2015) Karen Riiber Mandrup et al.   REPRODUCTIVE TOXICOLOGY

Prenatal exposure to di-(2-ethylhexyl) phthalate (DEHP) affects reproductive outcomes in female mice

(2015) Sarah Niermann et al.   REPRODUCTIVE TOXICOLOGY

The effects of in utero bisphenol A exposure on reproductive capacity in several generations of mice

(2015) Ayelet Ziv-Gal et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Exposure to bisphenol A in young adult mice does not alter ovulation but does alter the fertilization ability of oocytes

(2015) Teresita Rocio Moore-Ambriz et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Distinct actions of ancestral vinclozolin and juvenile stress on neural gene expression in the male rat

(2015) Ross Gillette et al.   Frontiers in Genetics

Daily Exposure to Di(2-ethylhexyl) Phthalate Alters Estrous Cyclicity and Accelerates Primordial Follicle Recruitment Potentially Via Dysregulation of the Phosphatidylinositol 3-Kinase Signaling Pathway in Adult Mice1

(2014) Patrick R. Hannon et al.   BIOLOGY OF REPRODUCTION

Estrogen-Negative Feedback and Estrous Cyclicity Are Critically Dependent Upon Estrogen Receptor-α Expression in the Arcuate Nucleus of Adult Female Mice

(2014) Shel-Hwa Yeo et al.   ENDOCRINOLOGY

Bisphenol A enhances kisspeptin neurons in anteroventral periventricular nucleus of female mice

(2014) Xiaoli Wang et al.   JOURNAL OF ENDOCRINOLOGY

Neuroendocrine and behavioral effects of maternal exposure to oral bisphenol A in female mice

(2014) Lydie Naulé et al.   JOURNAL OF ENDOCRINOLOGY

Perfluoroalkyl acid contamination of follicular fluid and its consequence for in vitro oocyte developmental competence

(2014) Evi M.L. Petro et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Investigation of the Effects of Subchronic Low Dose Oral Exposure to Bisphenol A (BPA) and Ethinyl Estradiol (EE) on Estrogen Receptor Expression in the Juvenile and Adult Female Rat Hypothalamus

(2014) Meghan E. Rebuli et al.   TOXICOLOGICAL SCIENCES

Trans-generational Effects of Early Life Stress: The Role of Maternal Behavior

(2014) Claudia Schmauss et al.   Scientific Reports

Developmental Timing of the Effects of Maternal Care on Gene Expression and Epigenetic Regulation of Hormone Receptor Levels in Female Rats

(2013) Catherine Jensen Peña et al.   ENDOCRINOLOGY

Developmental Programming: Gestational Bisphenol-A Treatment Alters Trajectory of Fetal Ovarian Gene Expression

(2013) Almudena Veiga-Lopez et al.   ENDOCRINOLOGY

Bisphenol A Exposure during Adulthood Causes Augmentation of Follicular Atresia and Luteal Regression by Decreasing 17β-Estradiol Synthesis via Downregulation of Aromatase in Rat Ovary

(2013) Seung Gee Lee et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The Impact of Endocrine Disruption: A Consensus Statement on the State of the Science

(2013) Åke Bergman et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Transgenerational effects of prenatal bisphenol A on social recognition

(2013) Jennifer T. Wolstenholme et al.   HORMONES AND BEHAVIOR

Epigenetic control of female puberty

(2013) Alejandro Lomniczi et al.   NATURE NEUROSCIENCE

A multi-generational study on low-dose BPA exposure in Wistar rats: Effects on maternal behavior, flavor intake and development

(2013) Sofiane Boudalia et al.   NEUROTOXICOLOGY AND TERATOLOGY

Plastics Derived Endocrine Disruptors (BPA, DEHP and DBP) Induce Epigenetic Transgenerational Inheritance of Obesity, Reproductive Disease and Sperm Epimutations

(2013) Mohan Manikkam et al.   PLoS One

Late-life effects on rat reproductive system after developmental exposure to mixtures of endocrine disrupters

(2013) Louise Krag Isling et al.   REPRODUCTION

Mixtures of endocrine-disrupting contaminants induce adverse developmental effects in preweaning rats

(2013) Marta Axelstad et al.   REPRODUCTION

Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction

(2013) Delphine Franssen et al.   REPRODUCTIVE TOXICOLOGY

Short-term neonatal/prepubertal exposure of dibutyl phthalate (DBP) advanced pubertal timing and affected hypothalamic kisspeptin/GPR54 expression differently in female rats

(2013) Jialei Hu et al.   TOXICOLOGY

Bridging the transgenerational gap with epigenetic memory

(2013) Jana P. Lim et al.   TRENDS IN GENETICS

Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A1

(2012) Sandra M. Losa-Ward et al.   BIOLOGY OF REPRODUCTION

Direct Regulation of GnRH Neuron Excitability by Arcuate Nucleus POMC and NPY Neuron Neuropeptides in Female Mice

(2012) Juan Roa et al.   ENDOCRINOLOGY

Gestational Exposure to Bisphenol A Produces Transgenerational Changes in Behaviors and Gene Expression

(2012) Jennifer T. Wolstenholme et al.   ENDOCRINOLOGY

Endocrine-disrupting chemicals in human follicular fluid impair in vitro oocyte developmental competence

(2012) Evi M.L. Petro et al.   HUMAN REPRODUCTION

Mixtures of endocrine disrupting contaminants modelled on human high end exposures: an exploratory study in rats

(2012) S. Christiansen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Transgenerational Actions of Environmental Compounds on Reproductive Disease and Identification of Epigenetic Biomarkers of Ancestral Exposures

(2012) Mohan Manikkam et al.   PLoS One

Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

(2012) Eric Nilsson et al.   PLoS One

Dioxin (TCDD) Induces Epigenetic Transgenerational Inheritance of Adult Onset Disease and Sperm Epimutations

(2012) Mohan Manikkam et al.   PLoS One

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

(2011) Felix Krueger et al.   BIOINFORMATICS

PRENATAL EPOXICONAZOLE EXPOSURE EFFECTS ON RAT POSTNATAL DEVELOPMENT

(2011) Vera L.S.S. de Castro et al.   BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY

Transcriptional regulation of the human KiSS1 gene

(2011) Johanna K. Mueller et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Neonatal Bisphenol A exposure alters sexually dimorphic gene expression in the postnatal rat hypothalamus

(2011) Jinyan Cao et al.   NEUROTOXICOLOGY

Urinary Concentrations of Four Parabens in the U.S. Population: NHANES 2005–2006

(2010) Antonia M. Calafat et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Perinatal Exposure to Environmentally Relevant Levels of Bisphenol A Decreases Fertility and Fecundity in CD-1 Mice

(2010) Nicolas J. Cabaton et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

In Vitro Effect of Octyl – Methoxycinnamate (OMC) on the Release of Gn-RH and Amino Acid Neurotransmitters by Hypothalamus of Adult Rats

(2010) S. Carbone et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Combined exposure to endocrine disrupting pesticides impairs parturition, causes pup mortality and affects sexual differentiation in rats

(2010) P. R. Jacobsen et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Neurobiological mechanisms underlying kisspeptin activation of gonadotropin-releasing hormone (GnRH) neurons at puberty

(2010) Jenny Clarkson et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Pubertal Assessment Method and Baseline Characteristics in a Mixed Longitudinal Study of Girls

(2010) F. M. Biro et al.   PEDIATRICS

Vinclozolin: A feasibility and sensitivity study of the ILSI-HESI F1-extended one-generation rat reproduction protocol

(2010) Steffen Schneider et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Developmental exposure to paracetamol causes anti-androgenic effects in male rat offspring

(2010) Ulla Hass et al.   REPRODUCTIVE TOXICOLOGY

Exposure of neonatal female rats to bisphenol A disrupts hypothalamic LHRH pre-mRNA processing and estrogen receptor alpha expression in nuclei controlling estrous cyclicity

(2010) L. Monje et al.   REPRODUCTIVE TOXICOLOGY

Neonatal exposure to bisphenol A reduces the pool of primordial follicles in the rat ovary

(2010) Horacio A. Rodríguez et al.   REPRODUCTIVE TOXICOLOGY

Low-dose perinatal exposure to di(2-ethylhexyl) phthalate induces anti-androgenic effects in male rats

(2010) Sofie Christiansen et al.   REPRODUCTIVE TOXICOLOGY

Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring

(2010) C. Adriana Mendoza-Rodríguez et al.   REPRODUCTIVE TOXICOLOGY

Effect of perinatal and postnatal bisphenol A exposure to the regulatory circuits at the hypothalamus–pituitary–gonadal axis of CD-1 mice

(2010) Wei Xi et al.   REPRODUCTIVE TOXICOLOGY

Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat

(2010) Sandra M. Losa et al.   REPRODUCTIVE TOXICOLOGY

Estrogenicity of Bisphenol A: A Concentration-Effect Relationship on Luteinizing Hormone Secretion in a Sensitive Model of Prepubertal Lamb

(2010) Séverine H. Collet et al.   TOXICOLOGICAL SCIENCES

Developmental programming: Impact of fetal exposure to endocrine-disrupting chemicals on gonadotropin-releasing hormone and estrogen receptor mRNA in sheep hypothalamus

(2010) Megan M. Mahoney et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Ovotoxicity and PPAR-mediated aromatase downregulation in female Sprague–Dawley rats following combined oral exposure to benzo[a]pyrene and di-(2-ethylhexyl) phthalate

(2010) Chuan Xu et al.   TOXICOLOGY LETTERS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Neonatal Bisphenol-A Exposure Alters Rat Reproductive Development and Ovarian Morphology Without Impairing Activation of Gonadotropin-Releasing Hormone Neurons1

(2009) Heather B. Adewale et al.   BIOLOGY OF REPRODUCTION

Synergistic Disruption of External Male Sex Organ Development by a Mixture of Four Antiandrogens

(2009) Sofie Christiansen et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neonatal Exposure to Bisphenol A Alters Reproductive Parameters and Gonadotropin Releasing Hormone Signaling in Female Rats

(2009) Marina Fernández et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Impact of the UV-B filter 4-(Methylbenzylidene)-camphor (4-MBC) during prenatal development in the neuroendocrine regulation of gonadal axis in male and female adult rats

(2009) M.E. Carou et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Collaborative work on evaluation of ovarian toxicity 10) Two- or four-week repeated dose studies and fertility study of di-(2-ethylhexyl) phthalate (DEHP) in female rats

(2009) Ryo Takai et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Perinatal exposure of rats to Bisphenol A affects the fertility of male offspring

(2009) Smita Salian et al.   LIFE SCIENCES

Recent Decline in Age at Breast Development: The Copenhagen Puberty Study

(2009) L. Aksglaede et al.   PEDIATRICS

Neonatal exposure to bisphenol A alters estrogen-dependent mechanisms governing sexual behavior in the adult female rat

(2009) L. Monje et al.   REPRODUCTIVE TOXICOLOGY

Effects of in utero through lactational exposure to dicyclohexyl phthalate and p,p′-DDE in Sprague–Dawley rats

(2009) Kanji Yamasaki et al.   TOXICOLOGY LETTERS

Octyl-Methoxycinnamate (OMC), an Ultraviolet (UV) Filter, Alters LHRH and Amino Acid Neurotransmitters Release from Hypothalamus of Immature Rats

(2008) B. Szwarcfarb et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Maternal influences on the sexual behavior and reproductive success of the female rat

(2008) Nicole M. Cameron et al.   HORMONES AND BEHAVIOR

Female sexual behavior, estrous cycle and gene expression in sexually dimorphic brain regions after pre- and postnatal exposure to endocrine active UV filters

(2008) Oliver Faass et al.   NEUROTOXICOLOGY

Maternal Programming of Sexual Behavior and Hypothalamic-Pituitary-Gonadal Function in the Female Rat

(2008) Nicole Cameron et al.   PLoS One

A Mixture of Five Phthalate Esters Inhibits Fetal Testicular Testosterone Production in the Sprague-Dawley Rat in a Cumulative, Dose-Additive Manner

(2008) Kembra L. Howdeshell et al.   TOXICOLOGICAL SCIENCES

Oxytocin Facilitates Female Sexual Maturation through a Glia-to-Neuron Signaling Pathway

(2007) Anne-Simone Parent et al.   ENDOCRINOLOGY