Caveolin-1-dependent activation of the metalloprotease TACE/ADAM17 by TGF-β in hepatocytes requires activation of Src and the NADPH oxidase NOX1

TGFβ1 rapidly activates Src through a non-canonical redox signaling mechanism

(2015) Hongqiao Zhang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Protein Kinase C (PKC) Increases TACE/ADAM17 Enzyme Activity in Porcine Ovarian Somatic Cells, Which Is Essential for Granulosa Cell Luteinization and Oocyte Maturation

(2014) Yasuhisa Yamashita et al.   ENDOCRINOLOGY

Caveolin-1 is required for TGF- β -induced transactivation of the EGF receptor pathway in hepatocytes through the activation of the metalloprotease TACE/ADAM17

(2014) J Moreno-Càceres et al.   Cell Death & Disease

Hepatocytes produce TNF-α following hypoxia-reoxygenation and liver ischemia-reperfusion in a NADPH oxidase- and c-Src-dependent manner

(2013) Netanya Y. Spencer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Redox regulation of protein kinases

(2013) Aoife Corcoran et al.   FEBS Journal

Src mediates the mechanical activation of myogenesis by activating TNF -converting enzyme

(2013) A. Niu et al.   JOURNAL OF CELL SCIENCE

ATP-Mediated Transactivation of the Epidermal Growth Factor Receptor in Airway Epithelial Cells Involves DUOX1-Dependent Oxidation of Src and ADAM17

(2013) Derek Sham et al.   PLoS One

Caveolin-1 abrogates TGF-β mediated hepatocyte apoptosis

(2013) C Meyer et al.   Cell Death & Disease

NADPH Oxidase NOX1 Controls Autocrine Growth of Liver Tumor Cells through Up-regulation of the Epidermal Growth Factor Receptor Pathway

(2010) Patricia Sancho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct role of endocytosis for Smad and non-Smad TGF-β signaling regulation in hepatocytes

(2010) Christoph Meyer et al.   JOURNAL OF HEPATOLOGY

A transforming Src mutant increases the bioavailability of EGFR ligands via stimulation of the cell-surface metalloproteinase ADAM17

(2010) T Maretzky et al.   ONCOGENE

Oxidative stress activates ADAM17/TACE and induces its target receptor shedding in platelets in a p38-dependent fashion

(2009) A. Brill et al.   CARDIOVASCULAR RESEARCH

Nox proteins in signal transduction

(2009) David I. Brown et al.   FREE RADICAL BIOLOGY AND MEDICINE

Impairment of Transforming Growth Factor β Signaling in Caveolin-1-deficient Hepatocytes

(2009) Rafael Mayoral et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial Reactive Oxygen Species Mediate GPCR–induced TACE/ADAM17-dependent Transforming Growth Factor-α Shedding

(2009) Timothy J. Myers et al.   MOLECULAR BIOLOGY OF THE CELL

Compartmentalization of Redox Signaling Through NADPH Oxidase–Derived ROS

(2008) Masuko Ushio-Fukai   ANTIOXIDANTS & REDOX SIGNALING

The inhibition of the epidermal growth factor (EGF) pathway enhances TGF-β-induced apoptosis in rat hepatoma cells through inducing oxidative stress coincident with a change in the expression pattern of the NADPH oxidases (NOX) isoforms

(2008) Patricia Sancho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Upregulation of the NADPH oxidase NOX4 by TGF-beta in hepatocytes is required for its pro-apoptotic activity

(2008) Irene Carmona-Cuenca et al.   JOURNAL OF HEPATOLOGY

Transforming Growth Factor   Engages TACE and ErbB3 To Activate Phosphatidylinositol-3 Kinase/Akt in ErbB2-Overexpressing Breast Cancer and Desensitizes Cells to Trastuzumab

(2008) S. E. Wang et al.   MOLECULAR AND CELLULAR BIOLOGY

The Involvement of the Tyrosine Kinase c-Src in the Regulation of Reactive Oxygen Species Generation Mediated by NADPH Oxidase-1

(2008) Davide Gianni et al.   MOLECULAR BIOLOGY OF THE CELL