Integrative structural biology ofTetrahymenatelomerase - insights into catalytic mechanism and interaction at telomeres

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The telomerase essential N-terminal domain promotes DNA synthesis by stabilizing short RNA-DNA hybrids

(2015) B. M. Akiyama et al.   NUCLEIC ACIDS RESEARCH

Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions

(2015) J. Jiang et al.   SCIENCE

The Tetrahymena telomerase p75–p45–p19 subcomplex is a unique CST complex

(2015) Bingbing Wan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Control of telomerase action at human telomeres

(2015) Dirk Hockemeyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Single-molecule imaging of telomerase reverse transcriptase in human telomerase holoenzyme and minimal RNP complexes

(2015) Robert Alexander Wu et al.   eLife

Direct Single-Stranded DNA Binding by Teb1 Mediates the Recruitment of Tetrahymena thermophila Telomerase to Telomeres

(2014) H. E. Upton et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of human TERT elements necessary for telomerase recruitment to telomeres

(2014) Jens C Schmidt et al.   eLife

Tetrahymena Telomerase Holoenzyme Assembly, Activation, and Inhibition by Domains of the p50 Central Hub

(2013) K. Hong et al.   MOLECULAR AND CELLULAR BIOLOGY

The architecture of Tetrahymena telomerase holoenzyme

(2013) Jiansen Jiang et al.   NATURE

Finding the end: recruitment of telomerase to telomeres

(2013) Jayakrishnan Nandakumar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Telomerase at the intersection of cancer and aging

(2013) Bruno Bernardes de Jesus et al.   TRENDS IN GENETICS

CST for the grand finale of telomere replication

(2013) Liuh-Yow Chen et al.   Nucleus

Roles of Telomerase Reverse Transcriptase N-terminal Domain in Assembly and Activity ofTetrahymenaTelomerase Holoenzyme

(2012) Barbara Eckert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A New Strategy for Detection and Development of Tractable Telomerase Inhibitors

(2012) Elysia P. M. T. Cohn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65

(2012) Mahavir Singh et al.   MOLECULAR CELL

The human CST complex is a terminator of telomerase activity

(2012) Liuh-Yow Chen et al.   NATURE

The telomere syndromes

(2012) Mary Armanios et al.   NATURE REVIEWS GENETICS

Biogenesis of telomerase ribonucleoproteins

(2012) E. D. Egan et al.   RNA

The Pot1a-associated proteins Tpt1 and Pat1 coordinate telomere protection and length regulation in Tetrahymena

(2011) Benjamin R. Linger et al.   MOLECULAR BIOLOGY OF THE CELL

It all comes together at the ends: Telomerase structure, function, and biogenesis

(2011) Joshua D. Podlevsky et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Structural basis for Tetrahymena telomerase processivity factor Teb1 binding to single-stranded telomeric-repeat DNA

(2011) Z. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of CST function in telomere maintenance

(2010) Carolyn Price et al.   CELL CYCLE

Structural basis for telomerase catalytic subunit TERT binding to RNA template and telomeric DNA

(2010) Meghan Mitchell et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Tribolium castaneum telomerase catalytic subunit TERT

(2008) Andrew J. Gillis et al.   NATURE

Triple-helix structure in telomerase RNA contributes to catalysis

(2008) Feng Qiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY