On the pivotal role of PPARα in adaptation of the heart to hypoxia and why fat in the diet increases hypoxic injury

Cardiac-specific ablation of ARNT leads to lipotoxicity and cardiomyopathy

(2014) Rongxue Wu et al.   JOURNAL OF CLINICAL INVESTIGATION

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice

(2014) Ruoli L. Chen et al.   JOURNAL OF NEUROCHEMISTRY

Effects of Prolonged Exposure to Hypobaric Hypoxia on Oxidative Stress, Inflammation and Gluco-Insular Regulation: The Not-So-Sweet Price for Good Regulation

(2014) Mario Siervo et al.   PLoS One

Broad Suppression of NADPH Oxidase Activity Exacerbates Ischemia/Reperfusion Injury Through Inadvertent Downregulation of Hypoxia-inducible Factor-1α and Upregulation of Peroxisome Proliferator–activated Receptor-α

(2013) Shouji Matsushima et al.   CIRCULATION RESEARCH

Mice expressing a human KATP channel mutation have altered channel ATP sensitivity but no cardiac abnormalities

(2012) R. Clark et al.   DIABETOLOGIA

Metabolic insight into mechanisms of high-altitude adaptation in Tibetans

(2012) Ri-Li Ge et al.   MOLECULAR GENETICS AND METABOLISM

A high-fat diet impairs cardiac high-energy phosphate metabolism and cognitive function in healthy human subjects

(2011) Cameron J Holloway et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

A high fat diet increases mitochondrial fatty acid oxidation and uncoupling to decrease efficiency in rat heart

(2011) Mark A. Cole et al.   BASIC RESEARCH IN CARDIOLOGY

Acclimatization of skeletal muscle mitochondria to high-altitude hypoxia during an ascent of Everest

(2011) Denny Z. Levett et al.   FASEB JOURNAL

Differential Sensitivity of Hypoxia Inducible Factor Hydroxylation Sites to Hypoxia and Hydroxylase Inhibitors

(2011) Ya-Min Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-energy phosphotransfer in the failing mouse heart: role of adenylate kinase and glycolytic enzymes

(2010) Dunja Aksentijević et al.   EUROPEAN JOURNAL OF HEART FAILURE

Cardiac response to hypobaric hypoxia: persistent changes in cardiac mass, function, and energy metabolism after a trek to Mt. Everest Base Camp

(2010) Cameron J. Holloway et al.   FASEB JOURNAL

PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition

(2010) Joy McCarthy et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Molecular distinction between physiological and pathological cardiac hypertrophy: Experimental findings and therapeutic strategies

(2010) Bianca C. Bernardo et al.   PHARMACOLOGY & THERAPEUTICS

Genetic Evidence for High-Altitude Adaptation in Tibet

(2010) T. S. Simonson et al.   SCIENCE

Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy

(2009) Jaya Krishnan et al.   Cell Metabolism

Application of a Proteolysis/Mass Spectrometry Method for Investigating the Effects of Inhibitors on Hydroxylase Structure

(2009) Christopher J. Stubbs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cardiac hypertrophy is enhanced in PPAR -/- mice in response to chronic pressure overload

(2008) P. J.H. Smeets et al.   CARDIOVASCULAR RESEARCH

Increased mitochondrial uncoupling proteins, respiratory uncoupling and decreased efficiency in the chronically infarcted rat heart

(2008) Andrew J. Murray et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Hypoxia-Inducible Factor-Dependent Degeneration, Failure, and Malignant Transformation of the Heart in the Absence of the von Hippel-Lindau Protein

(2008) L. Lei et al.   MOLECULAR AND CELLULAR BIOLOGY

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

(2008) Julián Aragonés et al.   NATURE GENETICS