Single-point mutation–mediated local amphipathic adjustment dramatically enhances antibacterial activity of a fungal defensin

Investigating the role of GXXXG motifs in helical folding and self-association of plasticins, Gly/Leu-rich antimicrobial peptides

(2015) Ludovic Carlier et al.   BIOPHYSICAL CHEMISTRY

A new antibiotic kills pathogens without detectable resistance

(2015) Losee L. Ling et al.   NATURE

Overexpression of human β-defensin 2 promotes growth and invasion during esophageal carcinogenesis

(2015) Ni Shi et al.   Oncotarget

The Influenza Hemagglutinin Fusion Domain Is an Amphipathic Helical Hairpin That Functions by Inducing Membrane Curvature

(2014) Sean T. Smrt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

(2014) B. C. Monk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eurocin, a New Fungal Defensin

(2012) Jesper S. Oeemig et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ab Initio Design of Potent Anti-MRSA Peptides Based on Database Filtering Technology

(2012) Biswajit Mishra et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Dermatophytic defensin with antiinfective potential

(2012) S. Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of NZ2114, a Novel Plectasin-Derived Cationic Antimicrobial Peptide Antibiotic, in Experimental Endocarditis Due to Methicillin-Resistant Staphylococcus aureus

(2011) Yan Q. Xiong et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Novel classes of antibiotics or more of the same?

(2011) Anthony RM Coates et al.   BRITISH JOURNAL OF PHARMACOLOGY

Road to clinical efficacy: challenges and novel strategies for antimicrobial peptide development

(2011) Randal Eckert   Future Microbiology

Coupled Folding and Specific Binding: Fishing for Amphiphilicity

(2011) Vikas P. Jain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Reduction of disulphide bonds unmasks potent antimicrobial activity of human β-defensin 1

(2011) Bjoern O. Schroeder et al.   NATURE

Designing antimicrobial peptides: form follows function

(2011) Christopher D. Fjell et al.   NATURE REVIEWS DRUG DISCOVERY

Identification and characterization of the parasitic wasp Nasonia defensins: Positive selection targeting the functional region?

(2010) Bin Gao et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II

(2010) T. Schneider et al.   SCIENCE

New approaches in peptide antibiotics

(2009) Martti Vaara   CURRENT OPINION IN PHARMACOLOGY

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Structural and functional characterization of two genetically related meucin peptides highlights evolutionary divergence and convergence in antimicrobial peptides

(2008) Bin Gao et al.   FASEB JOURNAL

Rational design of peptides active against the gram positive bacteriaStaphylococcus aureus

(2008) Céline Landon et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Discovery of six families of fungal defensin-like peptides provides insights into origin and evolution of the CSαβ defensins

(2007) Shunyi Zhu   MOLECULAR IMMUNOLOGY