Review
Immunology
Takehiko Yokomizo, Takao Shimizu
Summary: Leukotriene B-4 (LTB4) is a chemotactic factor for inflammatory cells derived from arachidonate, and an important drug target. The high-affinity LTB4 receptor, BLT1, is involved in the pathogenesis of various inflammatory and immune diseases. The low-affinity receptor, BLT2, is a receptor for 12-hydroxyheptadecatrienoic acid and is involved in maintaining barrier function and promoting wound healing. BLT1 antagonists and BLT2 agonists are potential candidates for treating inflammatory diseases.
IMMUNOLOGICAL REVIEWS
(2023)
Review
Pharmacology & Pharmacy
Kawthar Dhayni, Kazem Zibara, Hawra Issa, Said Kamel, Youssef Bennis
Summary: CXCR1 and CXCR2 chemokine receptors are critical in inflammation, and CXCR1/2 inhibitors show beneficial effects in preventing cardiovascular disease progression.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Pharmacology & Pharmacy
Huamei Forsman, Claes Dahlgren, Jonas Martensson, Lena Bjorkman, Martina Sundqvist
Summary: Human neutrophils, as professional phagocytes, express several G protein-coupled receptors (GPCRs) that are essential for their functions. Recently, the FFA receptors, GPR84 and FFA2, have attracted attention for their involvement in neutrophil activation. This review summarizes the current understanding of how GPR84 affects human neutrophil functions and discusses the regulatory mechanisms, comparing them to the two FPRs and FFA2.
BRITISH JOURNAL OF PHARMACOLOGY
(2023)
Review
Cell Biology
Yoichiro Kamimura, Masahiro Ueda
Summary: Chemotaxis is the process of cells undergoing directional movement along ambient chemical gradients, playing important roles in human physiology and pathology. Studies on Dictyostelium cells have elucidated the crucial roles of various mechanisms of GPCR signaling in broad range sensing of chemical gradients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jeffrey M. Schappi, Mark M. Rasenick
Summary: The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studied for decades. This review focuses on the role of cAMP, G proteins, and adenylyl cyclase in depression and antidepressant action. Both human and animal studies are compared, revealing that cAMP signaling is attenuated in depression and can be reversed by successful antidepressant therapy. The G protein G alpha(s) that activates adenylyl cyclase appears to have limited access to adenylyl cyclase in depression, but this can be rectified by successful antidepressant treatment. However, there is a discrepancy between human and animal studies in linking specific isoforms of adenylyl cyclase to depression or antidepressant action.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Seungheon Lee, Mi Ae Kim, Jong-Moon Park, Keunwan Park, Young Chang Sohn
Summary: This study reveals the TK signaling system in lophotrochozoan mollusks, specifically in the Pacific abalone Haliotis discus hannai (Hdh). The study identifies TK precursors and TK receptor isoforms in Hdh and characterizes Hdh-TK signaling. The findings suggest a possible role for TK peptides in regulating lipid metabolism in the neural and peripheral tissues of abalone.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Immunology
Shota Yamamoto, Takahiro Masuda
Summary: Microglia, resident macrophages in the CNS, play various roles in brain development and CNS diseases. Reprogramming of microglial cellular energetic metabolism has been identified as a crucial mechanism for their functionality diversification. Lipids, essential components of cell membranes, are tightly involved in microglial biology. This review provides a summary of current knowledge on microglial lipid metabolism in health and disease.
INFLAMMATION AND REGENERATION
(2023)
Review
Cell Biology
Fernando Montano-Rendon, Sergio Grinstein, Glenn F. W. Walpole
Summary: The dynamic reorganization of cellular membranes in myeloid and lymphoid cells of the immune system plays a crucial role in cellular physiology. Phosphoinositides, signaling lipids that control interface of biological membranes, are pivotal to functions like rolling adhesion, migration, and phagocytosis of leukocytes. Understanding the metabolism and downstream effectors of phosphoinositides is essential for immunity and disease research.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Jong Min Hong, Jin-Woo Lee, Dong-Seung Seen, Jae-Yeon Jeong, Won-Ki Huh
Summary: The heteromerization between CXCR4 and LPA1 has been investigated, showing its important role in cancer cells and providing insights into the regulatory mechanism of CXCR4 through heteromer formation. The findings suggest a potential therapeutic approach using combined CXCR4 and LPA1 inhibitors for cancer and inflammatory diseases associated with these receptors.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell Biology
Jin Zhou, Brijesh K. Singh, Jia Pei Ho, Andrea Lim, Eveline Bruinstroop, Kenji Ohba, Rohit A. Sinha, Paul M. Yen
Summary: The study demonstrated that MED1 plays a crucial role in regulating hepatic autophagy, mitochondria function, and lipid metabolism. It may affect the transcriptional activity of various NRs and transcription factors, and contribute to the development of nonalcoholic fatty liver disease.
Article
Mathematical & Computational Biology
Akinori Nishi, Katsuya Ohbuchi, Noriko Kaifuchi, Chika Shimobori, Hirotaka Kushida, Masahiro Yamamoto, Yoshihiro Kita, Suzumi M. Tokuoka, Ayako Yachie, Yukiko Matsuoka, Hiroaki Kitano
Summary: Lipid mediators play a crucial role in biological functions and diseases. The construction of a precise map of lipid mediator metabolic pathways helps visualize and understand the interactions of these factors, contributing to elucidating the comprehensive functional relationships and pathways of lipid mediators.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2021)
Article
Immunology
Melina Michael, Barry McCormick, Karen E. Anderson, Utsa Karmakar, Matthieu Vermeren, Stephane Schurmans, Augustin Amour, Sonja Vermeren
Summary: Neutrophils, the most abundant circulating leukocytes in humans, play key roles in host defense and inflammation. The study reveals the important regulatory function of the phosphatase SHIP2 in neutrophil chemotaxis and directionality, offering insights into the complexity of PI3K signaling in neutrophils.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Laura Miek, Paul M. Jordan, Kerstin Guenther, Simona Pace, Timo Beyer, David Kowalak, Verena Hoerr, Bettina Loeffler, Lorena Tuchscherr, Charles N. Serhan, Jana Gerstmeier, Oliver Werz
Summary: The study reveals that S. aureus infection can modulate lipid mediator pathways involved in inflammatory processes, resulting in a shift from anti-inflammatory M2-like signature profiles to pro-inflammatory M1-like signature profiles.
Article
Biochemistry & Molecular Biology
Danielle Kamato, Mai Gabr, Hirushi Kumarapperuma, Zheng J. Chia, Wenhua Zheng, Suowen Xu, Narin Osman, Peter J. Little
Summary: This study aimed to investigate the role of proximal G proteins in PAR-1 transactivation-dependent signaling. The findings showed that G alpha q is involved in PAR-1-mediated proteoglycan modification, while G alpha 11 has no effect. These findings are significant for the study of other GPCRs involved in vascular pathology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Yingying Lu, Guotao Lu, Lin Gao, Qingtian Zhu, Jing Xue, Jingzhu Zhang, Xiaojie Ma, Nan Ma, Qi Yang, Jie Dong, Weijuan Gong, Weiqin Li, Zhihui Tong
Summary: The study found that MaR1 exerts therapeutic and preventive effects on mouse AP by reducing macrophage infiltration and phenotype switch, but has no protective effect on pancreatic acinar cell line in vitro.
MEDIATORS OF INFLAMMATION
(2021)
Article
Immunology
Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, Mitsuyoshi Nakao, Takehiko Yokomizo
Summary: The study identified BLT1(hi) and BLT1(lo) DC subsets, showing different migration patterns towards LTB(4) and CCL21 respectively, contributing to allergic contact dermatitis. BLT1(hi)DCs promoted Th1 differentiation by upregulating IL-12p35 expression, while BLT1(lo)DCs accelerated T cell proliferation by producing IL-2.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Takuya Hara, Kazuko Saeki, Hiromi Jinnouchi, Saiko Kazuno, Yoshiki Miura, Takehiko Yokomizo
Summary: BLT2 is a GPCR mainly expressed in epithelial cells with lateral membrane localization, and its C-terminal domain plays a crucial role in maintaining epithelial barrier function. The interaction and transport mechanism of BLT2 to the plasma membrane, facilitated by LIN7C, contributes to its function in enhancing barrier function in epithelial cells.
Article
Biochemistry & Molecular Biology
Toshiaki Okuno, Takehiko Yokomizo
Summary: 12(S)-hydroxyheptadeca-5Z,8E,10E-trienoic acid (12-HHT) is a 17-carbon hydroxy fatty acid synthesized by enzymatic and non-enzymatic pathways. It acts as an endogenous agonist for BLT2, inducing cell migration and allergic inflammation. BLT2 is expressed in epithelial cells in mice and contributes to epithelial barrier functions.
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2021)
Article
Biochemistry & Molecular Biology
Yuri Hayashi, Hyeon-Cheol Lee-Okada, Eri Nakamura, Norihiro Tada, Takehiko Yokomizo, Yoko Fujiwara, Ikuyo Ichi
Summary: This study found that >= C20 PUFAs synthesized by FADS2 are crucial in regulating hepatic triacylglycerol and cholesterol accumulation during PUFA deficiency.
Article
Multidisciplinary Sciences
Nanase Takahashi, Toshiaki Okuno, Hiroki Fujii, Shintaro Makino, Masaya Takahashi, Mai Ohba, Kazuko Saeki, Atsuo Itakura, Satoru Takeda, Takehiko Yokomizo
Summary: The study revealed that the production of PGE(2) in fetal-membrane is influenced by COXs, cPGES, and SLCO2A1, which play roles in the accumulation of PGE(2) in amniotic fluid.
Article
Dermatology
Tomohiro Oiwa, Mami Ishibashi, Toshiaki Okuno, Mai Ohba, Yuichiro Endo, Ryuji Uozumi, Feras M. Ghazawi, Kazue Yoshida, Hironori Niizeki, Takehiko Yokomizo, Takashi Nomura, Kenji Kabashima
Summary: Pachydermoperiostosis (PDP) is a genetic disease characterized by abnormalities in plasma eicosanoid levels, with elevated PGE(2) levels playing a significant role in symptom presentation. Additionally, mutated SLCO2A1 gene in patients with a complete form of PDP leads to varying levels of PG, suggesting a dysfunctional eicosanoid homeostasis in these individuals.
JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryotaro Shioda, Airi Jo-Watanabe, Hyeon-Cheol Lee-Okada, Ken Yasukawa, Toshiaki Okuno, Yusuke Suzuki, Takehiko Yokomizo
Summary: This study compared the effects of n-3 polyunsaturated fatty acids, particularly perilla oil, with n-6 PUFA-rich soybean oil on renal insufficiency induced by IRI in rats. The results showed that a perilla oil-rich diet altered the composition of membrane phospholipids and lipid mediators in the kidney, but did not attenuate renal insufficiency or histological damage.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Editorial Material
Dermatology
Kahbing Jasmine Tan, Satoshi Nakamizo, Hyeon-Cheol Lee-Okada, Reiko Sato, Zachary Chow, Saeko Nakajima, John E. A. Common, Kazuko Saeki, Takehiko Yokomizo, Florent Ginhoux, Kenji Kabashima
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yosuke Ono, Takako Kawakita, Osamu Yoshino, Erina Sato, Kuniyuki Kano, Mai Ohba, Toshiaki Okuno, Masami Ito, Kaori Koga, Masako Honda, Akiko Furue, Takehiro Hiraoka, Shinichiro Wada, Takeshi Iwasa, Takehiko Yokomizo, Junken Aoki, Nagamasa Maeda, Nobuya Unno, Yutaka Osuga, Shuji Hirata
Summary: This study found that the concentration of S1P in the peritoneal fluid may be associated with endometriosis during both menstrual and non-menstrual phases. Experimental results suggest that S1P may play an important role in the formation and development of endometriosis lesions.
Article
Biochemistry & Molecular Biology
Yoko Hoshino, Toshiaki Okuno, Daisuke Saigusa, Kuniyuki Kano, Shota Yamamoto, Hideo Shindou, Junken Aoki, Kanji Uchida, Takehiko Yokomizo, Nobuko Ito
Summary: The study revealed the significant role of the LPA-LPA(1) signaling pathway in acute nociceptive pain, particularly in modulating neuronal sensitivity and pain behavior. The results indicate that LPA produced in innervated DRGs promotes the activation of SGCs, increasing neuronal sensitivity, and modulating pain behavior.
Article
Multidisciplinary Sciences
Miho Asahara, Nobuko Ito, Yoko Hoshino, Takaharu Sasaki, Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu, Yoshitsugu Yamada
Summary: The study examined the role of LTB4-BLT1 signaling in postoperative incisional pain and found that LTB4 exacerbates pain responses through promoting local infiltration of inflammatory monocytes and cytokine production. Therefore, LTB4-BLT1 signaling could be a potential therapeutic target for acute and persistent pain induced by tissue injury.
Article
Biochemistry & Molecular Biology
Ryotaro Shioda, Airi Jo-Watanabe, Toshiaki Okuno, Kazuko Saeki, Maiko Nakayama, Yusuke Suzuki, Takehiko Yokomizo
Summary: Leukotriene B-4 (LTB4) and its receptor BLT1 are the key factors in the pathogenesis of crescentic glomerulonephritis, and targeting them may be a potential therapeutic strategy for this disease.
Article
Biochemistry & Molecular Biology
Ken Yasukawa, Toshiaki Okuno, Narihito Ogawa, Yuichi Kobayashi, Takehiko Yokomizo
Summary: This study reveals that 12-HHT is metabolized into 12-KHT and 10,11dh-12-KHT by 15-PGDH and PTGR1, respectively, without losing its agonistic activity on BLT2.
JOURNAL OF BIOCHEMISTRY
(2022)
Review
Immunology
Takehiko Yokomizo, Takao Shimizu
Summary: Leukotriene B-4 (LTB4) is a chemotactic factor for inflammatory cells derived from arachidonate, and an important drug target. The high-affinity LTB4 receptor, BLT1, is involved in the pathogenesis of various inflammatory and immune diseases. The low-affinity receptor, BLT2, is a receptor for 12-hydroxyheptadecatrienoic acid and is involved in maintaining barrier function and promoting wound healing. BLT1 antagonists and BLT2 agonists are potential candidates for treating inflammatory diseases.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Hyeon-Cheol Lee-Okada, Kotaro Hama, Kazuaki Yokoyama, Takehiko Yokomizo
Summary: This study introduces a strategy for measuring FFAs in complex biological samples, using key methods such as isocratic LC separation, postcolumn base addition, and pseudo-multiple reaction monitoring. The method enables the measurement of various FFA species, including ultra-long-chain fatty acids.
JOURNAL OF BIOCHEMISTRY
(2021)