- Home
- Publications
- Publication Search
- Publication Details
Title
Positron emission tomographic imaging in drug discovery
Authors
Keywords
PET imaging, Drug development, Drug discovery, Receptor occupancy, Biodistribution, Pharmacokinetics, Pharmacodynamics, Drug treatment monitoring, Validation of target engagement
Journal
DRUG DISCOVERY TODAY
Volume -, Issue -, Pages -
Publisher
Elsevier BV
Online
2021-07-28
DOI
10.1016/j.drudis.2021.07.025
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Early Response Assessment to Targeted Therapy Using 3′-deoxy-3′[(18)F]-Fluorothymidine (18F-FLT) PET/CT in Lung Cancer
- (2020) Kalevi Kairemo et al. Diagnostics
- Reliability of dopamine transporter PET measurements with [18F]FE-PE2I in patients with Parkinson’s disease
- (2020) Vera S. Kerstens et al. EJNMMI Research
- Dealing with PET radiometabolites
- (2020) Krishna Kanta Ghosh et al. EJNMMI Research
- Role of 18F-FLT PET/CT in suspected recurrent or residual lymphoma: final results of a pilot prospective trial
- (2019) Lucia Zanoni et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Potential for imaging the high-affinity state of the 5-HT1B receptor: a comparison of three PET radioligands with differing intrinsic activity
- (2019) Anton Lindberg et al. EJNMMI Research
- The Current Status of Drug Discovery and Development as Originated in US Academia: The Influence of Industrial and Academic Collaboration on Drug Discovery and Development
- (2018) Tohru Takebe et al. CTS-Clinical and Translational Science
- Tumor-Specific Zr-89 Immuno-PET Imaging in a Human Bladder Cancer Model
- (2018) Freddy E. Escorcia et al. MOLECULAR IMAGING AND BIOLOGY
- Serotonin concentration enhancers at clinically relevant doses reduce [11C]AZ10419369 binding to the 5-HT1B receptors in the nonhuman primate brain
- (2018) Kai-Chun Yang et al. Translational Psychiatry
- Sample preparation techniques for radiometabolite analysis of positron emission tomography radioligands; trends, progress, limitations and future prospects
- (2018) Mohammad Mahdi Moein et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- 18 F-GP1, a Novel PET Tracer Designed for High-Sensitivity, Low-Background Detection of Thrombi
- (2017) Jessica Lohrke et al. JOURNAL OF NUCLEAR MEDICINE
- Investigation of the Brain Biodistribution of the Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitor [18F]GSK2647544 in Healthy Male Subjects
- (2016) Mickael Huiban et al. MOLECULAR IMAGING AND BIOLOGY
- Antibody Approaches To Treat Brain Diseases
- (2016) Vera Neves et al. TRENDS IN BIOTECHNOLOGY
- Pitfalls and Limitations of PET/CT in Brain Imaging
- (2015) Eric Salmon et al. SEMINARS IN NUCLEAR MEDICINE
- Week one FLT-PET response predicts complete remission to R-CHOP and survival in DLBCL
- (2015) Ken Herrmann et al. Oncotarget
- Brain PET in the Diagnosis of Alzheimer’s Disease
- (2014) Charles Marcus et al. CLINICAL NUCLEAR MEDICINE
- The role of molecular imaging in modern drug development
- (2014) Lídia Cunha et al. DRUG DISCOVERY TODAY
- International Validation Study for Interim PET in ABVD-Treated, Advanced-Stage Hodgkin Lymphoma: Interpretation Criteria and Concordance Rate Among Reviewers
- (2013) A. Biggi et al. JOURNAL OF NUCLEAR MEDICINE
- Positron Emission Tomography as a Method for Measuring Drug Delivery to Tumors in vivo: The Example of [11C]docetaxel
- (2013) Astrid A. M. van der Veldt et al. Frontiers in Oncology
- Development of [11C]erlotinib Positron Emission Tomography for In Vivo Evaluation of EGF Receptor Mutational Status
- (2012) I. Bahce et al. CLINICAL CANCER RESEARCH
- LMI1195 PET imaging in evaluation of regional cardiac sympathetic denervation and its potential role in antiarrhythmic drug treatment
- (2012) Ming Yu et al. EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
- Impaired cognition in bipolar I disorder: The roles of the serotonin transporter and brain-derived neurotrophic factor
- (2012) Yuan-Hwa Chou et al. JOURNAL OF AFFECTIVE DISORDERS
- Reactive Astrocytes Overexpress TSPO and Are Detected by TSPO Positron Emission Tomography Imaging
- (2012) S. Lavisse et al. JOURNAL OF NEUROSCIENCE
- Radiosynthesis and Preclinical Evaluation of 18F-F13714 as a Fluorinated 5-HT1A Receptor Agonist Radioligand for PET Neuroimaging
- (2012) L. Lemoine et al. JOURNAL OF NUCLEAR MEDICINE
- Performance of FDG PET/CT in the Clinical Management of Breast Cancer
- (2012) David Groheux et al. RADIOLOGY
- Determination of drug–receptor residence times by radioligand binding and functional assays: experimental strategies and physiological relevance
- (2012) Georges Vauquelin MedChemComm
- Positron emission tomography molecular imaging for drug development
- (2011) Paul M. Matthews et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Radioligand Binding to Brain Dopamine and Serotonin Receptors and Transporters in Parkinson's Disease: Relation to Gene Polymorphisms
- (2011) Cüneyt Güzey et al. INTERNATIONAL JOURNAL OF NEUROSCIENCE
- Predicting Brain Occupancy from Plasma Levels using PET: Superiority of Combining Pharmacokinetics with Pharmacodynamics while Modeling the Relationship
- (2011) Euitae Kim et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- Key Concepts of Clinical Trials: A Narrative Review
- (2011) Craig A. Umscheid et al. POSTGRADUATE MEDICINE
- Dose-dependent binding of AZD3783 to brain 5-HT1B receptors in non-human primates and human subjects: a positron emission tomography study with [11C]AZ10419369
- (2011) Katarina Varnäs et al. PSYCHOPHARMACOLOGY
- Affinity and selectivity of [11C]-(+)-PHNO for the D3 and D2 receptors in the rhesus monkey brain in vivo
- (2011) Jean-Dominique Gallezot et al. SYNAPSE
- Toward Molecular Imaging–Driven Drug Development in Oncology: Figure 1.
- (2011) Elisabeth G.E. de Vries et al. Cancer Discovery
- Approaches using molecular imaging technology — use of PET in clinical microdose studies
- (2010) Claudia C. Wagner et al. ADVANCED DRUG DELIVERY REVIEWS
- Imaging Dopamine D3 Receptors in the Human Brain with Positron Emission Tomography, [11C]PHNO, and a Selective D3 Receptor Antagonist
- (2010) Graham Searle et al. BIOLOGICAL PSYCHIATRY
- Pharmaceutical Innovation in the 21st Century: New Drug Approvals in the First Decade, 2000–2009
- (2010) K I Kaitin et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Towards Disease-Modifying Treatment of Alzheimers Disease: Drugs Targeting β -Amyloid
- (2010) V. Frisardi et al. Current Alzheimer Research
- Quantitative Analysis of [11C]AZ10419369 Binding to 5-HT1B Receptors in Human Brain
- (2010) Katarina Varnäs et al. JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
- 11C-PiB PET assessment of change in fibrillar amyloid-β load in patients with Alzheimer's disease treated with bapineuzumab: a phase 2, double-blind, placebo-controlled, ascending-dose study
- (2010) Juha O Rinne et al. LANCET NEUROLOGY
- PET radiotracers: crossing the blood–brain barrier and surviving metabolism
- (2009) Victor W. Pike TRENDS IN PHARMACOLOGICAL SCIENCES
- Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
- (2008) Milos D. Ikonomovic et al. BRAIN
- [11C]AZ10419369: A selective 5-HT1B receptor radioligand suitable for positron emission tomography (PET). Characterization in the primate brain
- (2008) M. Edward Pierson et al. NEUROIMAGE
- Usefulness of FDG-PET for early prediction of the response to gefitinib in non-small cell lung cancer
- (2007) Noriaki Sunaga et al. LUNG CANCER
Discover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversationFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search