A comprehensive series of Irx cluster mutants reveals diverse roles in facial cartilage development

IRX3 and IRX5 inhibit adipogenic differentiation of hypertrophic chondrocytes and promote osteogenesis

(2020) Zhijia Tan et al.   JOURNAL OF BONE AND MINERAL RESEARCH

IRX3/5 regulate mitotic chromatid segregation and limb bud shape

(2020) Hirotaka Tao et al.   DEVELOPMENT

Iroquois Proteins Promote Skeletal Joint Formation by Maintaining Chondrocytes in an Immature State

(2015) Amjad Askary et al.   DEVELOPMENTAL CELL

Spatial reconstruction of single-cell gene expression data

(2015) Rahul Satija et al.   NATURE BIOTECHNOLOGY

Formation of Proximal and Anterior Limb Skeleton Requires Early Function of Irx3 and Irx5 and Is Negatively Regulated by Shh Signaling

(2014) Danyi Li et al.   DEVELOPMENTAL CELL

Deep conservation of wrist and digit enhancers in fish

(2014) Andrew R. Gehrke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficient genome editing in zebrafish using a CRISPR-Cas system

(2013) Woong Y Hwang et al.   NATURE BIOTECHNOLOGY

Iroquois Homeodomain Transcription Factors in Heart Development and Function

(2012) Kyoung-Han Kim et al.   CIRCULATION RESEARCH

Mutations in IRX5 impair craniofacial development and germ cell migration via SDF1

(2012) Carine Bonnard et al.   NATURE GENETICS

An Essential Role of Variant Histone H3.3 for Ectomesenchyme Potential of the Cranial Neural Crest

(2012) Samuel G. Cox et al.   PLoS Genetics

An evolutionarily conserved three-dimensional structure in the vertebrate Irx clusters facilitates enhancer sharing and coregulation

(2011) Juan J. Tena et al.   Nature Communications

Jagged-Notch signaling ensures dorsal skeletal identity in the vertebrate face

(2010) E. Zuniga et al.   DEVELOPMENT

hand2 and Dlx genes specify dorsal, intermediate and ventral domains within zebrafish pharyngeal arches

(2010) J. C. Talbot et al.   DEVELOPMENT

Comparison of Iroquois gene expression in limbs/fins of vertebrate embryos

(2010) Laura A. McDonald et al.   JOURNAL OF ANATOMY

An evolutionarily conserved intronic region controls the spatiotemporal expression of the transcription factor Sox10

(2008) James R Dutton et al.   BMC DEVELOPMENTAL BIOLOGY