EDS1 signalling: At the nexus of intracellular and surface receptor immunity

Mutual potentiation of plant immunity by cell-surface and intracellular receptors

(2021) Bruno Pok Man Ngou et al.   NATURE

Pattern-recognition receptors are required for NLR-mediated plant immunity

(2021) Minhang Yuan et al.   NATURE

Origins and Immunity Networking Functions of EDS1 Family Proteins

(2020) Dmitry Lapin et al.   Annual Review of Phytopathology

Bacterial Effectors Induce Oligomerization of Immune Receptor ZAR1 In Vivo

(2020) Meijuan Hu et al.   Molecular Plant

Bacillus cereus AR156 triggers induced systemic resistance against Pseudomonas syringae pv. tomato DC3000 by suppressing miR472 and activating CNLs‐mediated basal immunity in Arabidopsis

(2020) Chunhao Jiang et al.   MOLECULAR PLANT PATHOLOGY

Convergent Loss of an EDS1/PAD4 Signaling Pathway in Several Plant Lineages Reveals Co-evolved Components of Plant Immunity and Drought Response

(2020) Erin Baggs et al.   PLANT CELL

Plant NLRs get by with a little help from their friends

(2020) Joanna M Feehan et al.   CURRENT OPINION IN PLANT BIOLOGY

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants

(2020) Zane Duxbury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Family of Mixed Lineage Kinase Domain-like Proteins in Plants and Their Role in Innate Immune Signaling

(2020) Lisa K. Mahdi et al.   Cell Host & Microbe

Intimate association of PRR- and NLR-mediated signaling in plant immunity

(2020) You Lu et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Two unequally redundant "helper" immune receptor families mediate Arabidopsis thaliana intracellular "sensor" immune receptor functions

(2020) Svenja C. Saile et al.   PLOS BIOLOGY

An EDS1 heterodimer signalling surface enforces timely reprogramming of immunity genes in Arabidopsis

(2019) Deepak D. Bhandari et al.   Nature Communications

Importance of OsRac1 and RAI 1 in signalling of NLR protein‐mediated resistance to rice blast disease

(2019) Zhuangzhi Zhou et al.   NEW PHYTOLOGIST

PBS3 Protects EDS1 from Proteasome-Mediated Degradation in Plant Immunity

(2019) Ming Chang et al.   Molecular Plant

Reconstitution and structure of a plant NLR resistosome conferring immunity

(2019) Jizong Wang et al.   SCIENCE

Jasmonic Acid-Involved OsEDS1 Signaling in Rice-Bacteria Interactions

(2019) Yinggen Ke et al.   Rice

The Arabidopsis Lectin Receptor Kinase LecRK-I.8 Is Involved in Insect Egg Perception

(2019) Caroline Gouhier-Darimont et al.   Frontiers in Plant Science

Activity and Phylogenetics of the Broadly Occurring Family of Microbial Nep1-Like Proteins

(2019) Michael F. Seidl et al.   Annual Review of Phytopathology

An EDS1-SAG101 Complex is Essential for TNL-mediated Immunity in Nicotiana benthamiana

(2019) Johannes Gantner et al.   PLANT CELL

A coevolved EDS1-SAG101-NRG1 module mediates cell death signaling by TIR-domain immune receptors

(2019) Dmitry Lapin et al.   PLANT CELL

TurboID-based proximity labeling reveals that UBR7 is a regulator of N NLR immune receptor-mediated immunity

(2019) Yongliang Zhang et al.   Nature Communications

RPW8/HR repeats control NLR activation in Arabidopsis thaliana

(2019) Cristina A. Barragan et al.   PLoS Genetics

Help wanted: helper NLRs and plant immune responses

(2019) Lance M Jubic et al.   CURRENT OPINION IN PLANT BIOLOGY

Plant cell surface immune receptor complex signaling

(2019) Wei-Lin Wan et al.   CURRENT OPINION IN PLANT BIOLOGY

Salicylic acid: biosynthesis, perception, and contributions to plant immunity

(2019) Yuelin Zhang et al.   CURRENT OPINION IN PLANT BIOLOGY

Cell surface immune receptors: the guardians of the plant’s extracellular spaces

(2019) Kostya Kanyuka et al.   CURRENT OPINION IN PLANT BIOLOGY

Arabidopsis immunity regulator EDS1 in a PAD4/SAG101-unbound form is a monomer with an inherently inactive conformation

(2019) Martin Voss et al.   JOURNAL OF STRUCTURAL BIOLOGY

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Arabidopsis PAD4 lipase-like domain is sufficient for resistance to green peach aphid

(2019) Joram Andreas Dongus et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

The large repertoire of conifer NLR resistance genes includes drought responsive and highly diversified RNLs

(2019) Cyril Van Ghelder et al.   Scientific Reports

An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

(2019) Hiroaki Adachi et al.   eLife

Arabidopsis EDR1 Protein Kinase Regulates the Association of EDS1 and PAD4 to Inhibit Cell Death

(2019) Matthew Neubauer et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Surface sensor systems in plant immunity

(2019) Isabell Albert et al.   PLANT PHYSIOLOGY

Structural, Functional, and Genomic Diversity of Plant NLR Proteins: An Evolved Resource for Rational Engineering of Plant Immunity

(2018) Freddy Monteiro et al.   Annual Review of Phytopathology

The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity

(2018) Neeraj K. Lal et al.   Cell Host & Microbe

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Antagonism of Transcription Factor MYC2 by EDS1/PAD4 Complexes Bolsters Salicylic Acid Defense in Arabidopsis Effector-Triggered Immunity

(2018) Haitao Cui et al.   Molecular Plant

Comparing Arabidopsis receptor kinase and receptor protein-mediated immune signaling reveals BIK1-dependent differences

(2018) Wei-Lin Wan et al.   NEW PHYTOLOGIST

Quantitative phosphoproteomic analysis reveals common regulatory mechanisms between effector- and PAMP-triggered immunity in plants

(2018) Yasuhiro Kadota et al.   NEW PHYTOLOGIST

Differential regulation of TNL-mediated immune signaling by redundant helper CNLs

(2018) Zhongshou Wu et al.   NEW PHYTOLOGIST

Diverse NLR immune receptors activate defence via the RPW8-NLR NRG1

(2018) Baptiste Castel et al.   NEW PHYTOLOGIST

Multiple intramolecular trafficking signals in RESISTANCE TO POWDERY MILDEW 8.2 are engaged in activation of cell death and defense

(2018) Yan‐Yan Huang et al.   PLANT JOURNAL

NRG1 functions downstream of EDS1 to regulate TIR-NLR-mediated plant immunity in Nicotiana benthamiana

(2018) Tiancong Qi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Structural Basis of Necroptotic Cell Death Signaling

(2018) Emma J. Petrie et al.   TRENDS IN BIOCHEMICAL SCIENCES

Revisiting the Origin of Plant NBS-LRR Genes

(2018) Zhu-Qing Shao et al.   TRENDS IN PLANT SCIENCE

Genome-wide functional analyses of plant coiled–coil NLR-type pathogen receptors reveal essential roles of their N-terminal domain in oligomerization, networking, and immunity

(2018) Tadeusz Wróblewski et al.   PLOS BIOLOGY

A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana

(2017) Florence Jacob et al.   NEW PHYTOLOGIST

Multiple functional self-association interfaces in plant TIR domains

(2017) Xiaoxiao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling from the plasma-membrane localized plant immune receptor RPM1 requires self-association of the full-length protein

(2017) Farid El Kasmi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLR network mediates immunity to diverse plant pathogens

(2017) Chih-Hang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unveiling the functional diversity of the alpha/beta hydrolase superfamily in the plant kingdom

(2016) Jeffrey T Mindrebo et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A core function of EDS1 with PAD4 is to protect the salicylic acid defense sector in Arabidopsis immunity

(2016) Haitao Cui et al.   NEW PHYTOLOGIST

Effector-Triggered Immunity: From Pathogen Perception to Robust Defense

(2015) Haitao Cui et al.   Annual Review of Plant Biology

Danger peptide receptor signaling in plants ensures basal immunity upon pathogen-induced depletion of BAK1

(2015) K. Yamada et al.   EMBO JOURNAL

How the Same Core Catalytic Machinery Catalyzes 17 Different Reactions: the Serine-Histidine-Aspartate Catalytic Triad of α/β-Hydrolase Fold Enzymes

(2015) Alissa Rauwerdink et al.   ACS Catalysis

An RLP23–SOBIR1–BAK1 complex mediates NLP-triggered immunity

(2015) Isabell Albert et al.   Nature Plants

Plant defence against aphids: the PAD4 signalling nexus

(2014) J. Louis et al.   JOURNAL OF EXPERIMENTAL BOTANY

BOTRYTIS-INDUCED KINASE1 Modulates Arabidopsis Resistance to Green Peach Aphids via PHYTOALEXIN DEFICIENT4

(2014) J. Lei et al.   PLANT PHYSIOLOGY

Structural Basis for Signaling by Exclusive EDS1 Heteromeric Complexes with SAG101 or PAD4 in Plant Innate Immunity

(2013) Stephan Wagner et al.   Cell Host & Microbe

Signalling of Arabidopsis thaliana response to Pieris brassicae eggs shares similarities with PAMP-triggered immunity

(2012) Caroline Gouhier-Darimont et al.   JOURNAL OF EXPERIMENTAL BOTANY

Expanded functions for a family of plant intracellular immune receptors beyond specific recognition of pathogen effectors

(2011) V. Bonardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA