Review
Biochemistry & Molecular Biology
Agnieszka Partyka, Wojciech Nizanski
Summary: The balance between ROS formation and the antioxidant system is crucial for cell function. Supplementation with antioxidants and other compounds shows potential for improving avian semen quality and fertility.
Article
Agriculture, Dairy & Animal Science
Tapendra Kumar, Pramod Kumar, Nirmala Saini, Shivendra Kumar Bhalothia, Chandan Prakash, Ajit Singh Mahla, Ashok Kumar
Summary: The study found that supplementation of 1 mM melatonin can effectively maintain seminal quality and alleviate oxidative stress during preservation at 4 degrees C for 72 h.
TROPICAL ANIMAL HEALTH AND PRODUCTION
(2022)
Review
Biochemistry & Molecular Biology
Miguel A. Silvestre, Jesus L. Yaniz, Fernando J. Pena, Pilar Santolaria, Maria Castello-Ruiz
Summary: The supplementation of antioxidants in extenders before refrigeration could reduce the detrimental effects of increased reactive oxidative species and decreased sperm quality parameters during long-term semen storage at refrigerated temperatures. However, the problem of oxidative stress in semen storage has not been fully resolved and the effects of antioxidants for semen-cooled storage have not been thoroughly reviewed.
Review
Endocrinology & Metabolism
Tarique Hussain, Mahmoud Kandeel, Elsayed Metwally, Ghulam Murtaza, Dildar Hussain Kalhoro, Yulong Yin, Bie Tan, Muhammad Ismail Chughtai, Anjaleena Yaseen, Ali Afzal, Muhammad Saleem Kalhoro
Summary: Male infertility is a global issue with oxidative stress being the main contributing factor, affecting sperm quality and quantity. Dysfunction of mitochondria and inflammation also play important roles in compromised fertility. The interaction between oxidative stress and seminal plasma proteomes further influences male infertility. Understanding these factors can help improve strategies to prevent male infertility.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Edidiong Nnamso Akang, Chinyerum Sylvia Opuwari, Swesme Enyioma-Alozie, Lionel Wildy Moungala, Tamarapreye Emmanuel Amatu, Ibrahim Wada, Rose Ogeyi Ogbeche, Oluwatoyin Omolayo Ajayi, Mojisola Modupe Aderonmu, Olaitan Boluwatife Shote, Lateef Adekunle Akinola, Oladapo Adenrele Ashiru, Ralf Henkel
Summary: A study on semen parameters in Nigeria and South Africa between 2010 and 2019 reveals a significant decline in sperm quality, highlighting the increasing male infertility problem in these regions.
SCIENTIFIC REPORTS
(2023)
Article
Obstetrics & Gynecology
Yi-Xiang Ye, Heng-Gui Chen, Bin Sun, Ying-Jun Chen, Peng Duan, Tian-Qing Meng, Cheng-Liang Xiong, Yi-Xin Wang, An Pan
Summary: The study found a negative association between the severity of depression and semen quality parameters, while a positive relationship was observed between depression and urinary 8-isoPGF2a concentrations. However, there was no evidence to suggest that the relationship between depression status and semen quality was mediated by oxidative stress markers.
FERTILITY AND STERILITY
(2022)
Article
Reproductive Biology
H. Izanloo, A. Soleimanzadeh, M. N. Bucak, M. Imani, M. Zhandi
Summary: This study investigated the effect of adding glutathione to turkey semen extenders on post-thawed semen quality and fertility. Results showed that 2, 1, and 0.5 mM of GSH in extenders improved motility, membrane integrity, and antioxidant capacity, with 2 mM GSH significantly increasing fertility in post-thawed turkey semen.
Article
Microbiology
Amol Arunrao Pohane, Caleb R. Carr, Jaishree Garhyan, Benjamin M. Swarts, M. Sloan Siegrist
Summary: Mycobacteria undergo mycomembrane remodeling under stress conditions, which includes synthesis and turnover. In the absence of trehalose recycling, there is ATP depletion, enhanced respiration, and oxidative stress. Energy-expensive macromolecule biosynthesis triggered in the absence of recycling may be a new paradigm for boosting host activity against bacterial pathogens.
Article
Biochemistry & Molecular Biology
Eva Tvrda, Michal Duracka, Filip Benko, Anton Kovacik, Daniel Lovisek, Eliska Galova, Jana Ziarovska, Marianna Schwarzova, Miroslava Kacaniova
Summary: This study aimed to describe the bacterial profiles of ejaculates collected after different ejaculatory abstinence periods and explore the associated changes in conventional, oxidative, and immunological characteristics of semen. The analysis revealed that samples collected after two days of abstinence had higher bacterial load and diversity, as well as a greater prevalence of potentially uropathogenic bacteria. However, samples obtained after two hours of abstinence showed a lower occurrence of bacteria. Additionally, shorter ejaculatory abstinence was found to contribute to better sperm quality and reduced damage by reactive oxygen species and pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Dairy & Animal Science
Yunfa Xie, Zhiying Chen, Yanling Wang, Xiayun Peng, Ni Feng, Xiaoye Wang, Yinsheng Tang, Xun Li, Chunrong Xu, Chuanhuo Hu
Summary: This study aimed to investigate the effects of Schisandrin B (Sch B) on the quality, oxidation resistance, and decapacitation of boar spermatozoa at 4 degrees C. The results showed that 10 μmol/L Sch B had significant positive effects on boar semen preservation at 4 degrees C. Cold storage can cause oxidative stress on boar spermatozoa, leading to impaired sperm function and fertilizing capacity.
Article
Agriculture, Dairy & Animal Science
Feng Zhang, Shichang Han, Nian Zhang, Jin Chai, Qi Xiong
Summary: This study aimed to investigate whether exogenous antioxidant ferulic acid (FA) can improve the quality of goat semen at 17 degrees C. The results showed that adding 50 mu mol/L of FA significantly improved semen quality for up to 5 days, and supplementing semen with 50 mu mol/L of FA at 17 degrees C for 3 days had no significant effect on fertility.
Article
Biochemistry & Molecular Biology
Eva Tvrda, Daniel Lovisek, Eliska Galova, Marianna Schwarzova, Eva Kovacikova, Simona Kunova, Jana Ziarovska, Miroslava Kacaniova
Summary: This study aimed to investigate the presence of bacteria in semen and their potential impact on sperm quality in normozoospermic men. The results showed that an increase in bacterial load and the presence of conditionally pathogenic bacteria were associated with decreased sperm quality. Additionally, the presence of bacteria in semen was accompanied by increased levels of pro-inflammatory cytokines, oxidative stress, and sperm structural deterioration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Avishek Biswas, Divya Sharma, Pramod K. Tyagi, Asitbaran Mandal
Summary: The study showed that supplementation of 750 μg Cr/kg in the diet improved the physico-biochemical properties, antioxidant levels, and oxidative stability of male turkey meat under refrigerated conditions.
ANIMAL BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
George Jitca, Erzsebet Fogarasi, Bianca-Eugenia Osz, Camil Eugen Vari, Ibolya Fulop, Mircea Dumitru Croitoru, Carmen Maria Rusz, Maria Titica Dogaru
Summary: This study successfully developed an HPLC/DAD method for detecting and quantifying GSH and GSSG levels in the rat brain, meeting validation criteria. The method has been applied in a chronic toxicology study of haloperidol under different treatment regimens.
Article
Agriculture, Dairy & Animal Science
Liuming Zhang, Yanhu Wang, Tariq Sohail, Yan Kang, Haoyuan Niu, Xiaomei Sun, Dejun Ji, Yongjun Li
Summary: The addition of Tau to Hu sheep semen preserved at room temperature has been shown to have a positive effect on sperm quality and antioxidant capacity. However, high concentrations of Tau may have negative effects. The presence of Tau can enhance the antioxidant ability of sperm, reduce lipid peroxidation, and improve the quality of semen stored at room temperature, suggesting its potential in enhancing reproductive performance of Hu sheep sperm.
Article
Chemistry, Multidisciplinary
Soraya Mahmoudi, Amir Abbas Farshid, Esmaeal Tamaddonfard, Mehdi Imani, Farahnaz Noroozinia
Summary: This study investigated the separate and combined effects of cinnamaldehyde and naloxone on the behavioral and histological outcomes induced by long-term morphine use. The results showed that cinnamaldehyde, naloxone, and their combination treatments improved the adverse effects of morphine, suggesting a neuroprotective effect through antioxidant, anti-inflammatory, apoptotic, and opioid receptor interaction mechanisms.
DRUG AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Laleh Mehryar, Mohsen Esmaiili, Fariba Zeynali, Mehdi Imani, Rohollah Sadeghi
Summary: The research investigated the effects of ethanol and methanol as desolvating agents at different temperatures on the fabrication of sunflower protein isolate (SnPI) nanoparticles, as well as the encapsulation efficiency of curcumin. Ethanol produced smaller and more uniform nanoparticles compared to methanol, with encapsulation efficiencies ranging from 39.1% to 95.4%. The release of curcumin from the nanoparticles exhibited a biphasic trend, with over 50% released in the first 2 hours due to the burst effect of the protein matrix.
Article
Agriculture, Dairy & Animal Science
Nastaran Shakouri, Ali Soleimanzadeh, Alaleh Rakhshanpour, Mustafa Numan Bucak
Summary: The study found that freezing sperm with 50, 30, and 70 μg/ml of DHPG concentrations improved sperm quality and oxidative markers significantly compared to the control group during the cryopreservation process.
REPRODUCTION IN DOMESTIC ANIMALS
(2021)
Article
Reproductive Biology
H. Izanloo, A. Soleimanzadeh, M. N. Bucak, M. Imani, M. Zhandi
Summary: This study investigated the effect of adding glutathione to turkey semen extenders on post-thawed semen quality and fertility. Results showed that 2, 1, and 0.5 mM of GSH in extenders improved motility, membrane integrity, and antioxidant capacity, with 2 mM GSH significantly increasing fertility in post-thawed turkey semen.
Article
Medicine, General & Internal
Mohammadreza Baqerkhani, Ali Soleimanzadeh, Hadi E. G. Ghaleh, Mahdieh Farzanehpour
Summary: The changing climate and weather may contribute to changing behaviors between humans and animals, leading to zoonotic diseases. Multiple factors, including zoonotic diseases and viral genetics, contribute to the emergence of new infections. Tracing and controlling new diseases can be challenging due to mutations and their unknown effects on virulence. Preventing emerging diseases is crucial for preventing pandemics.
ROMANIAN JOURNAL OF MILITARY MEDICINE
(2022)
Review
Oncology
Syeda Tasmia Asma, Ulas Acaroz, Kalman Imre, Adriana Morar, Syed Rizwan Ali Shah, Syed Zajif Hussain, Damla Arslan-Acaroz, Hayri Demirbas, Zehra Hajrulai-Musliu, Fatih Ramazan Istanbullugil, Ali Soleimanzadeh, Dmitry Morozov, Kui Zhu, Viorel Herman, Abdelhanine Ayad, Christos Athanassiou, Sinan Ince
Summary: Cancer is a deadly disease that has seen a significant rise in mortality rates globally. The search for potent anticancer agents has led to a focus on natural sources for novel and effective drugs. Plants and microbial species, chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties, have played a crucial role in producing effective anticancer agents. The clinical development of various plant-derived bioactive compounds against cancer, as well as the conjugation of natural compounds with anti-cancerous drugs, show promise in generating targeted treatment therapies. Awareness from pharmaceutical research studies in this field could lead to alternative drug development strategies that are economical, reliable, and safe to use.
Article
Veterinary Sciences
Negin Ramazani, Farid Mahd Gharebagh, Ali Soleimanzadeh, Halil Ozancan Arslan, Esin Keles, Desislava Georgieva Gradinarska-Yanakieva, Damla Arslan-Acaroz, Mahdi Zhandi, Alper Baran, Esmail Ayen, Dursun Ali Dinc
Summary: This study investigates the effects of cryopreservation and supplementation of Azeri water buffalo's semen with proline (Lp) and fulvic acid (FA). It aims to assess motility parameters, sperm viability, oxidative stress parameters, and DNA damage to determine the optimal concentrations of Lp and FA for buffalo semen cryopreservation. The results show that L-proline and fulvic acid supplementation can improve the quality parameters of post-thawed buffalo bull semen.
VETERINARY MEDICINE AND SCIENCE
(2023)
Article
Veterinary Sciences
Kimia Maleki, Esmail Ayen, Amir Khaki, Ali Soleimanzadeh
Summary: This study compared the effects of four extenders on semen quality and antioxidant levels, and found that Triladyl was the most suitable extender for semen freezing in Simmental bulls.
VETERINARY RESEARCH FORUM
(2023)
Article
Veterinary Sciences
Mohammad Moein Sabzeie, Esmail Ayen, Ali Soleimanzadeh, Mustafa Numan Bucak
Summary: This study examined the potential advantages of adding 40.00 μg/mL Tribulus terrestris aqueous extract (TTAE) to canine chilled sperm stored at 3°C for three days. The results showed that after 48 and 72 hours of liquid storage, the group with a concentration of 40.00 μg/mL TTAE exhibited better motility and viability compared to the control group. Additionally, after 72 hours of storage, the group with 40.00 μg/mL TTAE had lower malondialdehyde levels and higher antioxidant capacity. Therefore, the study suggests that supplementing the semen extender with 40.00 μg/mL TTAE can improve semen parameters after 72 hours of storage at 4.00°C, leading to improved fertilization efficiency.
VETERINARY RESEARCH FORUM
(2023)
Article
Veterinary Sciences
Reza Ijab, Esmail Ayen, Amir Khaki, Ali Soleimanzadeh
Summary: This study evaluated the effects of dietary betaine on semen quality in bulls and found that betaine supplementation improved sperm motility and viability, and reduced DNA fragmentation. However, betaine supplementation also resulted in decreased levels of seminal plasma antioxidants.
VETERINARY RESEARCH FORUM
(2022)
Article
Veterinary Sciences
Vali Abdoli, Roya Sarkhosh-Inanlou, Nowruz Delirezh, Safiyeh Aghazadeh, Nima Shaykh-Baygloo, Mehdi Imani
Summary: The novel protein toxin FraC demonstrated dose- and time-dependent cytotoxicity against K562 cells, with a complete destruction of cancer cells at a concentration of 35.00 μg mL(-1) after 72 hours. Furthermore, flow cytometry analysis revealed that FraC toxin induced necrosis and apoptosis in K562 cells in a dose-dependent manner.
VETERINARY RESEARCH FORUM
(2021)
Article
Veterinary Sciences
Leila Kianifard, Mohammad Yakhchali, Mehdi Imani
Summary: The study investigated the serine proteases activities in miracidia of Fasciola hepatica, with optimum activity at alkaline pH. Chemical and herbal inhibitors were found to decrease the proteases activities in the miracidia extract.
VETERINARY RESEARCH FORUM
(2021)
Article
Biology
Charles A. Elder, Jensen S. Smith, Mustafa Almosawi, Ethan Mills, Brett R. Janis, Jonathan A. Kopechek, Willem F. Wolkers, Michael A. Menze
Summary: By using a biomimetics approach and trehalose as a cryoprotective agent, red blood cells can be successfully preserved for long-term storage without the need for time-consuming washing steps.