Network pharmacology-based and molecular docking prediction of the active ingredients and mechanism of ZaoRenDiHuang capsules for application in insomnia treatment

SwissTargetPrediction: updated data and new features for efficient prediction of protein targets of small molecules

(2019) Antoine Daina et al.   NUCLEIC ACIDS RESEARCH

Association of Sleep Duration and Insomnia Symptoms with Components of Metabolic Syndrome and Inflammation in Middle-Aged and Older Adults with Metabolic Syndrome in Taiwan

(2019) Ahmad Syauqy et al.   Nutrients

Suanzaoren Formulae for Insomnia: Updated Clinical Evidence and Possible Mechanisms

(2018) Qi-Hui Zhou et al.   Frontiers in Pharmacology

Microglial signatures and their role in health and disease

(2018) Oleg Butovsky et al.   NATURE REVIEWS NEUROSCIENCE

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Insomnia symptoms combined with nocturnal hypoxia associate with cardiovascular comorbidity in the European sleep apnea cohort (ESADA)

(2018) Ulla Anttalainen et al.   Sleep and Breathing

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants

(2016) Janet Piñero et al.   NUCLEIC ACIDS RESEARCH

The STRING database in 2017: quality-controlled protein–protein association networks, made broadly accessible

(2016) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

GABA and 5-HT systems are implicated in the anxiolytic-like effect of spinosin in mice

(2015) Jie Liu et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

A novel systems pharmacology model for herbal medicine injection: a case using reduning injection

(2014) Haixing Yang et al.   BMC Complementary and Alternative Medicine

Transiently Increasing cAMP Levels Selectively in Hippocampal Excitatory Neurons during Sleep Deprivation Prevents Memory Deficits Caused by Sleep Loss

(2014) R. Havekes et al.   JOURNAL OF NEUROSCIENCE

UniProt: a hub for protein information

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Ameliorating effect of spinosin, a C-glycoside flavonoid, on scopolamine-induced memory impairment in mice

(2014) In Ho Jung et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Chronic Sleep Fragmentation Induces Endothelial Dysfunction and Structural Vascular Changes in Mice

(2014) Alba Carreras et al.   SLEEP

TCMSP: a database of systems pharmacology for drug discovery from herbal medicines

(2014) Jinlong Ru et al.   Journal of Cheminformatics

Shaping the interaction landscape of bioactive molecules

(2013) David Gfeller et al.   BIOINFORMATICS

A Novel Chemometric Method for the Prediction of Human Oral Bioavailability

(2012) Xue Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Network pharmacology-based prediction of the active ingredients and potential targets of Chinese herbal Radix Curcumae formula for application to cardiovascular disease

(2012) Weiyang Tao et al.   JOURNAL OF ETHNOPHARMACOLOGY

Chronic insomnia

(2012) Charles M Morin et al.   LANCET

Insomnia and risk of cardiovascular disease: a meta-analysis

(2012) Francesco Sofi et al.   European Journal of Preventive Cardiology

Rapid antidepressant changes with sleep deprivation in major depressive disorder are associated with changes in vascular endothelial growth factor (VEGF): A pilot study

(2011) Lobna Ibrahim et al.   BRAIN RESEARCH BULLETIN

Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence

(2011) Jerome Sarris et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

Insomnia as a predictor of depression: A meta-analytic evaluation of longitudinal epidemiological studies

(2011) Chiara Baglioni et al.   JOURNAL OF AFFECTIVE DISORDERS

Augmentative effect of spinosin on pentobarbital-induced loss of righting reflex in mice associated with presynaptic 5-HT1Areceptor

(2011) Li-En Wang et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach

(2011) Xijun Wang et al.   Journal of Proteomics

Toll-Like Receptor 4 Is a Regulator of Monocyte and Electroencephalographic Responses to Sleep Loss

(2011) Jonathan P. Wisor et al.   SLEEP

Prevalence and Polysomnographic Correlates of Insomnia Comorbid with Medical Disorders

(2011) Rohit Budhiraja et al.   SLEEP

Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT1A receptors

(2010) L.-E. Wang et al.   PHYTOMEDICINE

Effectiveness of Valerian on insomnia: A meta-analysis of randomized placebo-controlled trials

(2010) Ma Isabel Fernández-San-Martín et al.   SLEEP MEDICINE

A systematic review of insomnia and complementary medicine

(2010) Jerome Sarris et al.   SLEEP MEDICINE REVIEWS

Comparative Tolerability of Newer Agents for Insomnia

(2009) Gary Zammit   DRUG SAFETY

Sleep deprivation impairs cAMP signalling in the hippocampus

(2009) Christopher G. Vecsey et al.   NATURE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Epidemiological and clinical relevance of insomnia diagnosis algorithms according to the DSM-IV and the International Classification of Sleep Disorders (ICSD)

(2009) Maurice M. Ohayon et al.   SLEEP MEDICINE

Network pharmacology: the next paradigm in drug discovery

(2008) Andrew L Hopkins   Nature Chemical Biology