Article
Biochemistry & Molecular Biology
Richa Mishra, Lalita Mohan Behera, Soumendra Rana
Summary: hC5a, as a pro-inflammatory glycoprotein, plays an important role in drug research. Recent studies have shown that hC5a can cooperatively accommodate drugs at multiple sites, suggesting exploration of polypharmacology for targeting inflammatory diseases related to the "cytokine storm".
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Multidisciplinary Sciences
Mayank Batra, Runxia Tian, Chongxu Zhang, Emile Clarence, Camila Sofia Sacher, Justin Nestor Miranda, Justin Rafa O. De La Fuente, Megan Mathew, Desmond Green, Sayari Patel, Maria Virginia Perez Bastidas, Sara Haddadi, Mukunthan Murthi, Miguel Santiago Gonzalez, Shweta Kambali, Kayo H. M. Santos, Huda Asif, Farzaneh Modarresi, Mohammad Faghihi, Mehdi Mirsaeidi
Summary: This study found that titers of IgG targeting N-protein of SARS-CoV2 at admission are related to the clinical course of the disease. Higher CCI and IL6 levels were independently associated with in-hospital mortality while maintaining a high S/Co ratio (>1.5) also led to MICU admission and longer hospital stays.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Julian Full, Santosh P. Panchal, Julian Gotz, Ana-Maria Krause, Agnieszka Nowak-Krol
Summary: Helically chiral compounds with one and two boron atoms were synthesized using a modular approach, showing exceptional configurational stability and fluorescence properties. The compounds are proposed as primary structures of extended helices, with potential applications in materials science.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Immunology
Jesus Garcia-Donas, Diego Martinez-Urbistondo, Kyra Velazquez Kennedy, Paula Villares, Arantzazu Barquin, Andrea Dominguez, Juan Francisco Rodriguez-Moreno, Elena Caro, Rafael Suarez del Villar, Estanislao Nistal-Villan, Monica Yague, Maria Ortiz, Maria Barba, Sergio Ruiz-Llorente, Miguel Quiralte, Massimiliano Zanin, Cristina Rodriguez, Paloma Navarro, Pedro Berraondo, Rodrigo Madurga
Summary: Managing the inflammatory response to SARS-Cov-2 could prevent respiratory insufficiency. Cytokine profiles could identify cases at risk of severe disease.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Sanzio Dimai, Lukas Semmler, Ashok Prabhu, Harald Stachelscheid, Judith Huettemeister, Sandra C. Klaucke, Philipp Lacour, Florian Blaschke, Jan Kruse, Abdul Parwani, Leif-Hendrik Boldt, Lars Bullinger, Burkert M. Pieske, Frank R. Heinzel, Felix Hohendanner
Summary: Serum from COVID19 patients exerts acute cardio-depressant and chronic pro-arrhythmogenic effects in rat and iPS-derived cardiomyocytes. Canakinumab does not have beneficial effects on cellular Ca2+ signaling.
Article
Multidisciplinary Sciences
Nabil T. Fadai, Rahil Sachak-Patwa, Helen M. Byrne, Philip K. Maini, Mona Bafadhel, Dan V. Nicolau
Summary: This study presented a mathematical model of lung hyperinflammation due to SARS-CoV-2 infection, categorizing patients into distinct classes based on disease severity. Findings suggest that early intervention with locally acting anti-inflammatory agents like inhaled corticosteroids may effectively block the pathological hyperinflammatory response.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2021)
Article
Biochemistry & Molecular Biology
Jose L. Neira, Ana Camara-Artigas, Jose Gines Hernandez-Cifre, Maria Grazia Ortore
Summary: The research focused on the conformational characterization of Bacillus subtilis HPrK/P, revealing that the protein exhibited high conformational stability at pH 7.0, strong pH sensitivity, and denaturation through an oligomeric intermediate in guanidinium hydrochloride denaturation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Yang Zhao, Jingfa Yang, Minghua Liu, Jiang Zhao
Summary: Switchable inversion of chirality between opposite handedness by varying pH is found in a histidine pendant polymer, PBHis. This phenomenon is demonstrated by circular dichroism and fluorescence correlation spectroscopy, which measure the changes of hydrodynamic radius at the single molecular level. Below pH 8.0, the polyelectrolyte adopts M-helicity, while above pH 8.0, it changes into P-helicity. Above pH 10.6, the helicity further inverses into M-chirality. The protonation and deprotonation of the imidazole group, as well as the hydroxide-ion-mediated hydrogen bonding, determine the mutual orientation and handedness of the helical structure.
Article
Physics, Applied
Yilin Wang, Weijin Chen, Shilei Li, Zhi-Ling Hou, Li Yu
Summary: The extrinsic chiroptical effects based on directional nanoantennas are explored in this study. These effects are characterized by the angular emission patterns in momentum space, and can be tuned by changing the refractive index of the surrounding medium. This research provides a new perspective for understanding chirality and has important applications in biosensing and chiral photon detection.
JOURNAL OF APPLIED PHYSICS
(2022)
Review
Immunology
Nassima Chouaki Benmansour, Julien Carvelli, Eric Vivier
Summary: The overactivation of the complement system in severe cases of COVID-19 can lead to serious complications, and immunotherapies show promise in the treatment of the disease. Complement blockade, particularly targeting the C5a-C5aR axis, may help prevent the worsening of ARDS.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Muzaffar Hussain Najar, Oyais Ahmad Chat, Parvaiz Ahmad Bhat, Mohammad Amin Mir, Ghulam Mohamamd Rather, Aijaz Ahmad Dar
Summary: In this study, the interactions between a series of bile salts and trypsin were investigated using multiple techniques. The results showed that bile salts with higher hydrophobicity had stronger interactions with trypsin, leading to significant unfolding of the protein. The findings contribute to a better understanding of hydrophobicity-driven unfolding of proteins aided by biological surfactants like bile salts.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Infectious Diseases
Zheng Liu, Fang Shi, Jun-Xia Liu, Jia-Qi Liu, Jing Li, Qian Wang, Hui Wang, Chang-Lan Gao, Jian-Min Li, Dong-Fang Zhao
Summary: The use of corticosteroids in severe COVID-19 patients has been shown to reduce mortality rates in clinical trials recommended by the WHO and conducted in different countries, but its safety remains controversial. Administering corticosteroids at the appropriate timing and dosage in the early stages of COVID-19 pneumonia deterioration can effectively alleviate the condition.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Physics, Applied
S. Sharma, S. Shallcross, P. Elliott, S. Eisebitt, C. von Korff Schmising, J. K. Dewhurst
Summary: In the highly non-equilibrium conditions of laser-induced spin dynamics, the validity of using x-ray magnetic circular dichroism (XMCD) sum rules to track femtosecond spin dynamics remains an open question. This study compares spin moments obtained spectroscopically with those calculated directly from density functional theory (DFT) densities and finds that for low fluence pump pulses, the two methods are in excellent agreement. However, for short and/or intense pulses with high fluence, the XMCD sum rules fail with errors exceeding 50%, likely due to the excitation of charges out of the d-band and into sp-character bands.
APPLIED PHYSICS LETTERS
(2022)
Article
Physics, Multidisciplinary
D. Facciala, M. Devetta, S. Beauvarlet, N. Besley, F. Calegari, C. Callegari, D. Catone, E. Cinquanta, A. G. Ciriolo, L. Colaizzi, M. Coreno, G. Crippa, G. De Ninno, M. Di Fraia, M. Galli, G. A. Garcia, Y. Mairesse, M. Negro, O. Plekan, P. Prasannan Geetha, K. C. Prince, A. Pusala, S. Stagira, S. Turchini, K. Ueda, D. You, N. Zema, V. Blanchet, L. Nahon, I. Powis, C. Vozzi
Summary: Chirality is important in nature and its observation in chiral molecules is crucial for understanding and controlling chiral activity. The technique of time-resolved photoelectron circular dichroism (TR-PECD) offers a powerful tool for studying photoexcited chiral systems. However, the nonlocal nature of the PECD effect makes the interpretation of TR-PECD experiments challenging.
Article
Chemistry, Multidisciplinary
Mitsunobu Nakamura, Hibiki Yoshioka, Tadao Takada
Summary: DNA B-Z transitions are important in biological systems and DNA nanotechnology. We prepared pyrene-labelled DNA that can switch its conformation and fluorescence through a DNA B-Z transition.
Article
Biology
Kunal Bhattacharya, Shikha Mahato, Satyendra Deka, Nongmaithem Randhoni Chanu, Amit Kumar Shrivastava, Pukar Khanal
Summary: Chemoresistance, a major challenge in cancer treatment, is associated with the cellular glutathione-related detoxification system. A study has identified GSTP1 enzyme as critical in the inactivation of anticancer drugs and suggests the need for GSTP1 inhibitors to combat chemoresistance. Through molecular docking and simulations, the study found that quercetin 7-O-beta-D-glucoside showed promise as a potential candidate for addressing chemoresistance in cancer patients.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Manwi Shankar, Majji Sai Sudha Rani, Priyanka Gopi, P. Arsha, Prateek Pandya
Summary: This study investigates the interaction between the food dye BBY and the serum protein BSA. The results show that BBY binds to a specific site on BSA through hydrophobic interactions, affecting the structural stability of the protein. These findings enhance our understanding of the molecular-level interactions between BBY and BSA.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Chi Zhang, Qian Gao, Ming Li, Tianfei Yu
Summary: In this study, we propose a graph neural network-based autoencoder model, AGraphSAGE, that effectively predicts protein-protein interactions across diverse biological species by integrating gene ontology.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Kangjie Wu, Liqian Xu, Xinxiang Li, Youhua Zhang, Zhenyu Yue, Yujia Gao, Yiqiong Chen
Summary: Named Entity Recognition (NER) is a crucial task in natural language processing (NLP) and big data analysis, with wide application range. This paper proposes an improved neural network method for NER of rice genes and phenotypes, which can learn semantic information in the context without feature engineering. Experimental results show that the proposed model outperforms other models.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Suman Hait, Sudip Kundu
Summary: Interactions between amino acids in proteins are crucial for stability and structural integrity. Thermophiles have more and more stable interactions to survive in extreme environments. Different types of interactions are enriched in different structural regions.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Kountay Dwivedi, Ankit Rajpal, Sheetal Rajpal, Virendra Kumar, Manoj Agarwal, Naveen Kumar
Summary: This study aims to identify biomarkers for non-small cell lung cancer (NSCLC) using copy number variation (CNV) data. A novel deep learning architecture, XL1R-Net, is proposed to improve the classification accuracy for NSCLC subtyping. Twenty NSCLC-relevant biomarkers are uncovered using explainable AI (XAI)-based feature identification. The results show that the identified biomarkers have high classification performance and clinical relevance. Additionally, twelve of the biomarkers are potentially druggable and eighteen of them have a high probability of predicting NSCLC patients' survival likelihood according to the Drug-Gene Interaction Database and the K-M Plotter tool, respectively. This research suggests that investigating these seven novel biomarkers can contribute to NSCLC therapy, and the integration of multiomics data and other sources will help better understand NSCLC heterogeneity.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)
Article
Biology
Pengli Lu, Wenqi Zhang, Jinkai Wu
Summary: Researchers have developed a computational method, AMPCDA, to predict circRNA-disease associations using predefined metapaths, achieving high predictive accuracy. This method effectively combines node embeddings with higher-order neighborhood representations and provides valuable guidance for revealing new disease mechanisms in biological research.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2024)