Immunologic treatments for precancerous lesions and uterine cervical cancer

Emerging Biological Treatments for Uterine Cervical Carcinoma

(2014) Patrizia Vici et al.   Journal of Cancer

Evidence for a Role of the PD-1:PD-L1 Pathway in Immune Resistance of HPV-Associated Head and Neck Squamous Cell Carcinoma

(2013) S. Lyford-Pike et al.   CANCER RESEARCH

Human papillomavirus and cervical cancer

(2013) Emma J Crosbie et al.   LANCET

A Chlamydomonas-Derived Human Papillomavirus 16 E7 Vaccine Induces Specific Tumor Protection

(2013) Olivia C. Demurtas et al.   PLoS One

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions

(2012) Peggy J. de Vos van Steenwijk et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TriVax-HPV: an improved peptide-based therapeutic vaccination strategy against human papillomavirus-induced cancers

(2012) Kelly Barrios et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Emerging human papillomavirus vaccines

(2012) Barbara Ma et al.   EXPERT OPINION ON EMERGING DRUGS

Human papillomavirus 16 L1–E7 chimeric virus like particles show prophylactic and therapeutic efficacy in murine model of cervical cancer

(2012) Chandresh Sharma et al.   VACCINE

A prime/boost strategy by DNA/fowlpox recombinants expressing a mutant E7 protein for the immunotherapy of HPV-associated cancers

(2012) Antonia Radaelli et al.   VIRUS RESEARCH

Intraperitoneal administration of poly(I:C) with polyethylenimine leads to significant antitumor immunity against murine ovarian tumors

(2011) Chao-Yi Wu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

CD4+ T-cell response against human papillomavirus type 16 E6 protein is associated with a favorable clinical trend

(2011) Kevin H. Kim et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Immunization with a poly (lactide co-glycolide) encapsulated plasmid DNA expressing antigenic regions of HPV 16 and 18 results in an increase in the precursor frequency of T cells that respond to epitopes from HPV 16, 18, 6 and 11

(2011) Mark Matijevic et al.   CELLULAR IMMUNOLOGY

PROVENGE (Sipuleucel-T) in Prostate Cancer: The First FDA-Approved Therapeutic Cancer Vaccine

(2011) M. A. Cheever et al.   CLINICAL CANCER RESEARCH

Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms

(2011) Mikayel Mkrtichyan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tobacco derived cancer vaccines for non-Hodgkin’s lymphoma: Perspectives and progress

(2011) Alison A. McCormick   Human vaccines & immunotherapeutics

The known unknowns of HPV natural history

(2011) Patti E. Gravitt   JOURNAL OF CLINICAL INVESTIGATION

Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma

(2011) Francesca Paolini et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Papillomavirus E5: the smallest oncoprotein with many functions

(2011) Aldo Venuti et al.   Molecular Cancer

Ipilimumab: A novel immunostimulatory monoclonal antibody for the treatment of cancer

(2011) Grazia Graziani et al.   PHARMACOLOGICAL RESEARCH

HLA-E expression by gynecological cancers restrains tumor-infiltrating CD8+ T lymphocytes

(2011) M. Gooden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of simultaneous silencing of HPV-18 E6 and E7 on inducing apoptosis in HeLa cellsThis paper is one of a selection of papers published in this special issue entitled “Second International Symposium on Recent Advances in Basic, Clinical, and Social Medicine” and has undergone the Journal's usual peer review process.

(2010) Zongli Qi et al.   Biochemistry and Cell Biology

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

(2010) S Daayana et al.   BRITISH JOURNAL OF CANCER

CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy

(2010) Yuchun Cao et al.   CLINICAL IMMUNOLOGY

Plant-derived vaccines and other therapeutics produced in contained systems

(2010) Rosella Franconi et al.   Expert Review of Vaccines

Control of Cervicovaginal HPV-16 E7-Expressing Tumors by the Combination of Therapeutic HPV Vaccination and Vascular Disrupting Agents

(2010) Qi Zeng et al.   HUMAN GENE THERAPY

Therapeutic HPV DNA vaccines

(2010) Ken Lin et al.   IMMUNOLOGIC RESEARCH

The detection of circulating human papillomavirus-specific T cells is associated with improved survival of patients with deeply infiltrating tumors

(2010) Moniek Heusinkveld et al.   INTERNATIONAL JOURNAL OF CANCER

Cell-Mediated Immune Responses to Human Papillomavirus 16 E6 and E7 Antigens as Measured by Interferon Gamma Enzyme-Linked Immunospot in Women With Cleared or Persistent Human Papillomavirus Infection

(2010) Sepideh Farhat et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

A Favorable Clinical Trend Is Associated With CD8 T-Cell Immune Responses to the Human Papillomavirus Type 16 E6 Antigens in Women Being Studied for Abnormal Pap Smear Results

(2010) Mayumi Nakagawa et al.   Journal of Lower Genital Tract Disease

Efficient secretion of a modified E7 protein from human papilloma virus type-16 by Lactococcus lactis

(2010) D. Quistián-Martínez et al.   LETTERS IN APPLIED MICROBIOLOGY

Success or failure of vaccination for HPV16-positive vulvar lesions correlates with kinetics and phenotype of induced T-cell responses

(2010) M. J. P. Welters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Carrageenan as an adjuvant to enhance peptide-based vaccine potency

(2010) Yu-Qian Zhang et al.   VACCINE

Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7

(2010) Katsuyuki Adachi et al.   VACCINE

Enhancement of protein vaccine potency by in vivo electroporation mediated intramuscular injection

(2010) Tae Heung Kang et al.   VACCINE

HPV-16 E5 down-regulates expression of surface HLA class I and reduces recognition by CD8 T cells

(2010) M.S. Campo et al.   VIROLOGY

Serological response to an HPV16 E7 based therapeutic vaccine in women with high-grade cervical dysplasia

(2009) Koenraad Van Doorslaer et al.   GYNECOLOGIC ONCOLOGY

Progress and challenges in the vaccine-based treatment of head and neck cancers

(2009) Aldo Venuti   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Papillomavirus Prophylactic Vaccines: Established Successes, New Approaches

(2009) M. S. Campo et al.   JOURNAL OF VIROLOGY

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

(2009) Paulo Cesar Maciag et al.   VACCINE

An E7-based therapeutic vaccine protects mice against HPV16 associated cancer

(2009) Aldo Venuti et al.   VACCINE

Development of an Adenoviral Vaccine Against E6 and E7 Oncoproteins to Prevent Growth of Human Papillomavirus–Positive Cancer

(2008) Dong Wook Lee et al.   ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY

Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts

(2008) Chih-Wen Tseng et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Induction of Tumor-Specific CD4+ and CD8+ T-Cell Immunity in Cervical Cancer Patients by a Human Papillomavirus Type 16 E6 and E7 Long Peptides Vaccine

(2008) M. J.P. Welters et al.   CLINICAL CANCER RESEARCH

Phase I Immunotherapeutic Trial with Long Peptides Spanning the E6 and E7 Sequences of High-Risk Human Papillomavirus 16 in End-Stage Cervical Cancer Patients Shows Low Toxicity and Robust Immunogenicity

(2008) G. G. Kenter et al.   CLINICAL CANCER RESEARCH

Pretreatment with Cisplatin Enhances E7-Specific CD8+ T-Cell-Mediated Antitumor Immunity Induced by DNA Vaccination

(2008) C.-W. Tseng et al.   CLINICAL CANCER RESEARCH

A Phase I Trial of a Human Papillomavirus DNA Vaccine for HPV16+ Cervical Intraepithelial Neoplasia 2/3

(2008) C. L. Trimble et al.   CLINICAL CANCER RESEARCH

Antitumor Activity of DNA Vaccines Based on the Human Papillomavirus-16 E7 Protein Genetically Fused to a Plant Virus Coat Protein

(2008) Silvia Massa et al.   HUMAN GENE THERAPY

Diminished IFN-γ and IL-10 and elevated Foxp3 mRNA expression in the cervix are associated with CIN 2 or 3

(2008) Mark E. Scott et al.   INTERNATIONAL JOURNAL OF CANCER

Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination

(2008) Chih-Wen Tseng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Treatment of Vulvar Intraepithelial Neoplasia with Topical Imiquimod

(2008) Manon van Seters et al.   NEW ENGLAND JOURNAL OF MEDICINE

Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors

(2008) Duane A. Sewell et al.   VACCINE