The Pharmacology and Clinical Efficacy of Antiseizure Medications: From Bromide Salts to Cenobamate and Beyond

The ups and downs of alkyl‐carbamates in epilepsy therapy: How does cenobamate differ?

(2021) Wolfgang Löscher et al.   EPILEPSIA

What has been the impact of new drug treatments on epilepsy?

(2020) Zhibin Chen et al.   CURRENT OPINION IN NEUROLOGY

Therapeutic Strategies for Treatment-resistant Depression: State of the Art and Future Perspectives

(2020) Kah K. Goh et al.   CURRENT PHARMACEUTICAL DESIGN

Pharmacodynamic interactions of antiepileptic drugs: From bench to clinical practice

(2020) Alberto Verrotti et al.   EPILEPSY & BEHAVIOR

Structural, Molecular, and Functional Alterations of the Blood-Brain Barrier during Epileptogenesis and Epilepsy: A Cause, Consequence, or Both?

(2020) Wolfgang Löscher et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epilepsy in older people

(2020) Arjune Sen et al.   LANCET

30 years of second-generation antiseizure medications: impact and future perspectives

(2020) Emilio Perucca et al.   LANCET NEUROLOGY

Cenobamate for focal seizures — a game changer?

(2020) Jacqueline A. French   Nature Reviews Neurology

Current and Emerging Treatments of Essential Tremor

(2020) William George Ondo   NEUROLOGIC CLINICS

Dravet Syndrome: A Review of Current Management

(2020) James W. Wheless et al.   PEDIATRIC NEUROLOGY

Infantile spasms: Outcome in clinical studies

(2020) Raili Riikonen   PEDIATRIC NEUROLOGY

Current and Emerging Pharmacotherapy for Fibromyalgia

(2020) Roie Tzadok et al.   Pain Research & Management

Update on Drug Management of Refractory Epilepsy in Tuberous Sclerosis Complex

(2020) Emma van der Poest Clement et al.   PEDIATRIC DRUGS

Seizure freedom as an outcome in epilepsy treatment clinical trials

(2020) Jonathan J. Halford et al.   ACTA NEUROLOGICA SCANDINAVICA

Does cannabidiol have antiseizure activity independent of its interactions with clobazam? An appraisal of the evidence from randomized controlled trials

(2020) Meir Bialer et al.   EPILEPSIA

Epilepsy: key experimental therapeutics in early clinical development

(2020) Claude Steriade et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial

(2020) James M Chamberlain et al.   LANCET

Mechanisms of action of currently used antiseizure drugs

(2020) Graeme J. Sills et al.   NEUROPHARMACOLOGY

Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial

(2020) Cynthia Sharpe et al.   PEDIATRICS

Non-Dopaminergic Treatments for Motor Control in Parkinson’s Disease: An Update

(2020) Paulina Gonzalez-Latapi et al.   CNS DRUGS

Precision medicine and therapies of the future

(2020) Sanjay M. Sisodiya   EPILEPSIA

Drug Resistance in Epilepsy: Clinical Impact, Potential Mechanisms, and New Innovative Treatment Options

(2020) Wolfgang Löscher et al.   PHARMACOLOGICAL REVIEWS

Lennox-Gastaut syndrome: New treatments and treatments under investigation

(2020) S. Auvin   REVUE NEUROLOGIQUE

Recommendations for the treatment of epilepsy in adult and pediatric patients in Belgium: 2020 update

(2020) Paul Boon et al.   ACTA NEUROLOGICA BELGICA

Cenobamate (XCOPRI): Can preclinical and clinical evidence provide insight into its mechanism of action?

(2020) Michelle Guignet et al.   EPILEPSIA

Proceedings of the 15th Antiepileptic Drug and Device Trials Meeting: State of the Science

(2020) Christina M. Boada et al.   EPILEPSY & BEHAVIOR

Trigeminal Neuralgia

(2020) Giorgio Cruccu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prevention of Epilepsy in Infants with Tuberous Sclerosis Complex in the EPISTOP Trial

(2020) Katarzyna Kotulska et al.   ANNALS OF NEUROLOGY

Zonisamide for the Treatment of Parkinson Disease: A Current Update

(2020) Chengqian Li et al.   Frontiers in Neuroscience

Pharmacotherapy of Anxiety Disorders: Current and Emerging Treatment Options

(2020) Amir Garakani et al.   Frontiers in Psychiatry

Systematic evaluation of rationally chosen multitargeted drug combinations: a combination of low doses of levetiracetam, atorvastatin and ceftriaxone exerts antiepileptogenic effects in a mouse model of acquired epilepsy

(2020) Lisa Welzel et al.   NEUROBIOLOGY OF DISEASE

Adenosine kinase: A key regulator of purinergic physiology

(2020) Detlev Boison et al.   BIOCHEMICAL PHARMACOLOGY

A Clinical Overview of Off-label Use of Gabapentinoid Drugs

(2019) Christopher W. Goodman et al.   JAMA Internal Medicine

Current Status of Antiepileptic Drugs as Preventive Migraine Therapy

(2019) Simy K. Parikh et al.   Current Treatment Options in Neurology

The holy grail of epilepsy prevention: Preclinical approaches to antiepileptogenic treatments

(2019) Wolfgang Löscher   NEUROPHARMACOLOGY

Modeling genetic epilepsies in a dish

(2019) Wei Niu et al.   DEVELOPMENTAL DYNAMICS

The path from scientific discovery to cures for epilepsy

(2019) Gemma L. Carvill et al.   NEUROPHARMACOLOGY

Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives

(2019) IE Overwater et al.   Therapeutics and Clinical Risk Management

Recent Advances in the Drug Treatment of Dravet Syndrome

(2019) Elaine C. Wirrell et al.   CNS DRUGS

Drug–drug interactions and pharmacodynamics of concomitant clobazam and cannabidiol or stiripentol in refractory seizures

(2019) Pavel Klein et al.   EPILEPSY & BEHAVIOR

No prevention or cure of epilepsy as yet

(2019) Pavel Klein et al.   NEUROPHARMACOLOGY

Pharmacoresistance – Epidemiology, mechanisms, and impact on epilepsy treatment

(2019) Mubeen Janmohamed et al.   NEUROPHARMACOLOGY

Executive Summary: Management of epilepsy in pregnancy: A report from the International League Against Epilepsy Task Force on Women and Pregnancy

(2019) Torbjörn Tomson et al.   EPILEPSIA

An explorative literature review of the multifactorial causes of osteoporosis in epilepsy

(2019) Sarah Seberg Diemar et al.   EPILEPSY & BEHAVIOR

The Current Approach of the Epilepsy Therapy Screening Program Contract Site for Identifying Improved Therapies for the Treatment of Pharmacoresistant Seizures in Epilepsy.

(2019) Karen S. Wilcox et al.   NEUROPHARMACOLOGY

Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus

(2019) Jaideep Kapur et al.   NEW ENGLAND JOURNAL OF MEDICINE

Fenfluramine hydrochloride for the treatment of seizures in Dravet syndrome: a randomised, double-blind, placebo-controlled trial

(2019) Lieven Lagae et al.   LANCET

Safety and efficacy of adjunctive cenobamate (YKP3089) in patients with uncontrolled focal seizures: a multicentre, double-blind, randomised, placebo-controlled, dose-response trial

(2019) Gregory L Krauss et al.   LANCET NEUROLOGY

Proof-of-concept that network pharmacology is effective to modify development of acquired temporal lobe epilepsy

(2019) Alina Schidlitzki et al.   NEUROBIOLOGY OF DISEASE

Fenfluramine for Treatment-Resistant Seizures in Patients With Dravet Syndrome Receiving Stiripentol-Inclusive Regimens

(2019) Rima Nabbout et al.   JAMA Neurology

Modifying genetic epilepsies – Results from studies on tuberous sclerosis complex

(2019) Sergiusz Jozwiak et al.   NEUROPHARMACOLOGY

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs II: Treatment-resistant epilepsy

(2018) Andres M. Kanner et al.   NEUROLOGY

Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs I: Treatment of new-onset epilepsy

(2018) Andres M. Kanner et al.   NEUROLOGY

Etiology and Pharmacology of Neuropathic Pain

(2018) Sascha R. A. Alles et al.   PHARMACOLOGICAL REVIEWS

Seizure cluster: Definition, prevalence, consequences, and management

(2018) Saba Jafarpour et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Therapeutic Drug Monitoring of Antiepileptic Drugs in Epilepsy

(2018) Philip N. Patsalos et al.   THERAPEUTIC DRUG MONITORING

Comparative efficacy of antiepileptic drugs for patients with generalized epileptic seizures: systematic review and network meta-analyses

(2018) Marília Silveira de Almeida Campos et al.   International Journal of Clinical Pharmacy

Treatment Outcomes in Patients With Newly Diagnosed Epilepsy Treated With Established and New Antiepileptic Drugs

(2018) Zhibin Chen et al.   JAMA Neurology

A viewpoint on rational and irrational fixed-drug combinations

(2018) Barbara Błaszczyk et al.   Expert Review of Clinical Pharmacology

Epilepsy

(2018) Orrin Devinsky et al.   Nature Reviews Disease Primers

Antiepileptic monotherapy in newly diagnosed focal epilepsy. A network meta-analysis

(2018) Simona Lattanzi et al.   ACTA NEUROLOGICA SCANDINAVICA

Current concepts on epilepsy management in tuberous sclerosis complex

(2018) Maria Paola Canevini et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS

Acute Symptomatic Seizures and Provoked Seizures: to Treat or Not to Treat?

(2018) Nisali Gunawardane et al.   Current Treatment Options in Neurology

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

(2018) Meir Bialer et al.   EPILEPSIA

From molecules to medicines: the dawn of targeted therapies for genetic epilepsies

(2018) Scott T. Demarest et al.   Nature Reviews Neurology

The pharmacological management of Lennox-Gastaut syndrome and critical literature review

(2018) Alberto Verrotti et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Operational classification of seizure types by the International League Against Epilepsy: Position Paper of the ILAE Commission for Classification and Terminology

(2017) Robert S. Fisher et al.   EPILEPSIA

ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology

(2017) Ingrid E. Scheffer et al.   EPILEPSIA

Phenytoin: 80 years young, from epilepsy to breast cancer, a remarkable molecule with multiple modes of action

(2017) Jan M. Keppel Hesselink et al.   JOURNAL OF NEUROLOGY

Efficacy and safety of antiepileptic drugs for refractory partial-onset epilepsy: a network meta-analysis

(2017) Qingting Hu et al.   JOURNAL OF NEUROLOGY

The Anticonvulsant Screening Program of the National Institute of Neurological Disorders and Stroke, NIH: History and Contributions to Clinical Care in the Twentieth Century and Beyond

(2017) Roger J. Porter et al.   NEUROCHEMICAL RESEARCH

Animal Models of Seizures and Epilepsy: Past, Present, and Future Role for the Discovery of Antiseizure Drugs

(2017) Wolfgang Löscher   NEUROCHEMICAL RESEARCH

Neurodevelopmental Effects of Antiepileptic Drugs

(2017) Marissa Kellogg et al.   NEUROCHEMICAL RESEARCH

The National Institute of Neurological Disorders and Stroke (NINDS) Epilepsy Therapy Screening Program (ETSP)

(2017) John H. Kehne et al.   NEUROCHEMICAL RESEARCH

Antiepileptic Drugs and Liver Disease

(2017) Jorge Vidaurre et al.   PEDIATRIC NEUROLOGY

Drug development for refractory epilepsy: The past 25 years and beyond

(2017) Ambica Golyala et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges

(2017) Lancelot J. Millar et al.   Frontiers in Cellular Neuroscience

Synaptic Vesicle Glycoprotein 2A Ligands in the Treatment of Epilepsy and Beyond

(2016) Wolfgang Löscher et al.   CNS DRUGS

mTOR Inhibitors in Children: Current Indications and Future Directions in Neurology

(2016) Anna Jeong et al.   Current Neurology and Neuroscience Reports

Pharmacotherapy for Neonatal Seizures: Current Knowledge and Future Perspectives

(2016) Maria D. Donovan et al.   DRUGS

Brivaracetam: Rationale for discovery and preclinical profile of a selective SV2A ligand for epilepsy treatment

(2016) Henrik Klitgaard et al.   EPILEPSIA

Single dose efficacy evaluation of two partial benzodiazepine receptor agonists in photosensitive epilepsy patients: A placebo-controlled pilot study

(2016) Dorothée G.A. Kasteleijn-Nolst Trenité et al.   EPILEPSY RESEARCH

Fit for purpose application of currently existing animal models in the discovery of novel epilepsy therapies

(2016) Wolfgang Löscher   EPILEPSY RESEARCH

Hyponatremia induced by antiepileptic drugs in patients with epilepsy

(2016) Xi Lu et al.   Expert Opinion On Drug Safety

Adjunctive everolimus therapy for treatment-resistant focal-onset seizures associated with tuberous sclerosis (EXIST-3): a phase 3, randomised, double-blind, placebo-controlled study

(2016) Jacqueline A French et al.   LANCET

Valproic acid after five decades of use in epilepsy: time to reconsider the indications of a time-honoured drug

(2016) Torbjörn Tomson et al.   LANCET NEUROLOGY

Management of psychiatric and neurological comorbidities in epilepsy

(2016) Andres M. Kanner   Nature Reviews Neurology

Evidence-Based Guideline: Treatment of Convulsive Status Epilepticus in Children and Adults: Report of the Guideline Committee of the American Epilepsy Society

(2016) Tracy Glauser et al.   Epilepsy Currents

Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy

(2016) Gary P. Brennan et al.   Cold Spring Harbor Perspectives in Medicine

Mechanisms of Action of Antiseizure Drugs and the Ketogenic Diet

(2016) Michael A. Rogawski et al.   Cold Spring Harbor Perspectives in Medicine

Seizure clusters

(2015) Sheryl R. Haut   CURRENT OPINION IN NEUROLOGY

Cannabidiol can improve complex sleep-related behaviours associated with rapid eye movement sleep behaviour disorder in Parkinson's disease patients: a case series

(2014) M. H. N. Chagas et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

The Pharmacology of Imepitoin: The First Partial Benzodiazepine Receptor Agonist Developed for the Treatment of Epilepsy

(2013) Chris Rundfeldt et al.   CNS DRUGS

Rapid loss of efficacy to the antiseizure drugs lamotrigine and carbamazepine: A novel experimental model of pharmacoresistant epilepsy

(2013) Ajay K. Srivastava et al.   EPILEPSIA

Updated ILAE evidence review of antiepileptic drug efficacy and effectiveness as initial monotherapy for epileptic seizures and syndromes

(2013) Tracy Glauser et al.   EPILEPSIA

New avenues for anti-epileptic drug discovery and development

(2013) Wolfgang Löscher et al.   NATURE REVIEWS DRUG DISCOVERY

Pregabalin for the treatment of generalized anxiety disorder: an update

(2013) David Baldwin et al.   Neuropsychiatric Disease and Treatment

Molecular Therapies for Tuberous Sclerosis and Neurofibromatosis

(2012) David Neal Franz et al.   Current Neurology and Neuroscience Reports

Current position of phenobarbital in epilepsy and its future

(2012) Martin J. Brodie et al.   EPILEPSIA

Why are antiepileptic drugs used for nonepileptic conditions?

(2012) Meir Bialer   EPILEPSIA

Tolerability of antiepileptic drugs: Can we determine differences?

(2012) Joyce A. Cramer   EPILEPSY & BEHAVIOR

Clinical efficacy and safety of the newer antiepileptic drugs as adjunctive treatment in adults with refractory partial-onset epilepsy: A meta-analysis of randomized placebo-controlled trials

(2012) Lan Gao et al.   EPILEPSY RESEARCH

Teratogenic effects of antiepileptic drugs

(2012) Torbjörn Tomson et al.   LANCET NEUROLOGY

Perampanel—new promise for refractory epilepsy?

(2012) Wolfgang Löscher et al.   Nature Reviews Neurology

Anxioselective anxiolytics: on a quest for the Holy Grail

(2012) Phil Skolnick   TRENDS IN PHARMACOLOGICAL SCIENCES

Clinical comparability of the new antiepileptic drugs in refractory partial epilepsy: A systematic review and meta-analysis

(2011) João Costa et al.   EPILEPSIA

Modern antiepileptic drug development has failed to deliver: Ways out of the current dilemma

(2011) Wolfgang Löscher et al.   EPILEPSIA

Management of refractory status epilepticus in adults: still more questions than answers

(2011) Andrea O Rossetti et al.   LANCET NEUROLOGY

Combining antiepileptic drugs—Rational polytherapy?

(2011) Martin J. Brodie et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Ethosuximide, Valproic Acid, and Lamotrigine in Childhood Absence Epilepsy

(2010) Tracy A. Glauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Some treatments cause seizure aggravation in idiopathic epilepsies (especially absence epilepsy)

(2009) Ernest R. Somerville   EPILEPSIA

Recommendation for a definition of acute symptomatic seizure

(2009) Ettore Beghi et al.   EPILEPSIA

Key factors in the discovery and development of new antiepileptic drugs

(2009) Meir Bialer et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of Antiepileptic Drugs in Adults

(2009) Linda J. Stephen et al.   NEUROLOGIC CLINICS

Antiepileptic drugsbest practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

(2008) Philip N. Patsalos et al.   EPILEPSIA