Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development

Targeted Blockade of TARP-γ8-Associated AMPA Receptors: Anticonvulsant Activity with the Selective Antagonist LY3130481 (CERC-611)

(2018) Jeffrey M. Witkin et al.   CNS & Neurological Disorders-Drug Targets

Potent and selective pharmacodynamic synergy between the metabotropic glutamate receptor subtype 2-positive allosteric modulator JNJ-46356479 and levetiracetam in the mouse 6-Hz (44-mA) model

(2018) Cameron S. Metcalf et al.   EPILEPSIA

Design and Mechanism of (S)-3-Amino-4-(difluoromethylenyl)cyclopent-1-ene-1-carboxylic Acid, a Highly Potent γ-Aminobutyric Acid Aminotransferase Inactivator for the Treatment of Addiction

(2018) Jose I. Juncosa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Selective targeting of Scn8a prevents seizure development in a mouse model of mesial temporal lobe epilepsy

(2018) Jennifer C. Wong et al.   Scientific Reports

Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). II. Drugs in more advanced clinical development

(2018) Meir Bialer et al.   EPILEPSIA

Efficacy of mGlu2 -positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures

(2017) Cameron S. Metcalf et al.   EPILEPSIA

Progress report on new antiepileptic drugs: A summary of the Thirteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIII)

(2017) Meir Bialer et al.   EPILEPSIA

Chronic inhibition of brain glycolysis initiates epileptogenesis

(2017) Evgeniya Samokhina et al.   JOURNAL OF NEUROSCIENCE RESEARCH

From genotype to phenotype in Dravet disease

(2017) Svetlana Gataullina et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Evaluation of the in vitro and in vivo metabolic pathway and cytochrome P450 inhibition/induction profile of Huperzine A

(2016) Ping-ping Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Lamotrigine and levetiracetam exert a similar modulation of TMS-evoked EEG potentials

(2016) Isabella Premoli et al.   EPILEPSIA

SCN8Aencephalopathy: Research progress and prospects

(2016) Miriam H. Meisler et al.   EPILEPSIA

Effect of a single dose of retigabine in cortical excitability parameters: A cross-over, double-blind placebo-controlled TMS study

(2016) Michel Ossemann et al.   EPILEPSY RESEARCH

South (S)- and North (N)-Methanocarba-7-Deazaadenosine Analogues as Inhibitors of Human Adenosine Kinase

(2016) Kiran S. Toti et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of the First α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonist Dependent upon Transmembrane AMPA Receptor Regulatory Protein (TARP) γ-8

(2016) Kevin M. Gardinier et al.   JOURNAL OF MEDICINAL CHEMISTRY

Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression

(2016) Justine M. Kent et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Use of dietary therapies amongst patients with GLUT1 deficiency syndrome

(2016) Hannah R. Kass et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Huperzine A Provides Robust and Sustained Protection against Induced Seizures in Scn1a Mutant Mice

(2016) Jennifer C. Wong et al.   Frontiers in Pharmacology

Progress report on new antiepileptic drugs: A summary of the Twelfth Eilat Conference (EILAT XII)

(2015) Meir Bialer et al.   EPILEPSY RESEARCH

Efficacy of and Patient Compliance with a Ketogenic Diet in Adults with Intractable Epilepsy: A Meta-Analysis

(2015) Fang Ye et al.   Journal of Clinical Neurology

Epigenetics and Epilepsy

(2015) David C. Henshall et al.   Cold Spring Harbor Perspectives in Medicine

Dietary Treatments and New Therapeutic Perspective in GLUT1 Deficiency Syndrome

(2014) Pierangelo Veggiotti et al.   Current Treatment Options in Neurology

Psychiatric and neurologic risk factors for incident cases of new-onset epilepsy in older adults: Data from U.S. Medicare beneficiaries

(2014) Roy C. Martin et al.   EPILEPSIA

Posttraumatic epilepsy — Disease or comorbidity?

(2014) Asla Pitkänen et al.   EPILEPSY & BEHAVIOR

Convulsive seizures and SUDEP in a mouse model of SCN8A epileptic encephalopathy

(2014) Jacy L. Wagnon et al.   HUMAN MOLECULAR GENETICS

Epigenetic changes induced by adenosine augmentation therapy prevent epileptogenesis

(2013) Rebecca L. Williams-Karnesky et al.   JOURNAL OF CLINICAL INVESTIGATION

The Major Brain Cholesterol Metabolite 24(S)-Hydroxycholesterol Is a Potent Allosteric Modulator of N-Methyl-D-Aspartate Receptors

(2013) S. M. Paul et al.   JOURNAL OF NEUROSCIENCE

Glial adenosine kinase – A neuropathological marker of the epileptic brain

(2013) Eleonora Aronica et al.   NEUROCHEMISTRY INTERNATIONAL

The mechanism of action of retigabine (ezogabine), a first-in-class K+ channel opener for the treatment of epilepsy

(2012) Martin J. Gunthorpe et al.   EPILEPSIA

Epileptic Encephalopathies in Infants and Children

(2012) Douglas R. Nordli   JOURNAL OF CLINICAL NEUROPHYSIOLOGY

High-Resolution Proteomics Unravel Architecture and Molecular Diversity of Native AMPA Receptor Complexes

(2012) Jochen Schwenk et al.   NEURON

Mechanisms of physiological and epileptic HFO generation

(2012) John G.R. Jefferys et al.   PROGRESS IN NEUROBIOLOGY

The Expanding Social Network of Ionotropic Glutamate Receptors: TARPs and Other Transmembrane Auxiliary Subunits

(2011) Alexander C. Jackson et al.   NEURON

Levetiracetam in the treatment of epilepsy

(2011) Bassel Abou-Khalil   Neuropsychiatric Disease and Treatment

Targeting tumor metabolism with 2-deoxyglucose in patients with castrate-resistant prostate cancer and advanced malignancies

(2010) Mark Stein et al.   PROSTATE

Anticonvulsant and antiepileptic actions of 2-deoxy-D-glucose in epilepsy models

(2009) Carl E. Stafstrom et al.   ANNALS OF NEUROLOGY

Visual Field Loss in Patients with Refractory Partial Epilepsy Treated with Vigabatrin

(2009) John M. Wild et al.   CNS DRUGS

Pharmacodynamic and pharmacokinetic interactions between common antiepileptic drugs and acetone, the chief anticonvulsant ketone body elevated in the ketogenic diet in mice

(2009) Iwona Zarnowska et al.   EPILEPSIA

From traumatic brain injury to posttraumatic epilepsy: What animal models tell us about the process and treatment options

(2009) Asla Pitkänen et al.   EPILEPSIA

Ketogenic diets: Evidence for short- and long-term efficacy

(2009) Eric H. Kossoff et al.   Neurotherapeutics

Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats

(2008) Gabriel Zimmerman et al.   EUROPEAN JOURNAL OF NEUROSCIENCE