Pharmacogenetic Predictors of Cannabidiol Response and Tolerability in Treatment‐Resistant Epilepsy

Quantifying the burden of generalized tonic‐clonic seizures in patients with drug‐resistant epilepsy

(2020) Shehryar R Sheikh et al.   EPILEPSIA

Clinical implications of trials investigating drug‐drug interactions between cannabidiol and enzyme inducers or inhibitors or common antiseizure drugs

(2020) Philip N. Patsalos et al.   EPILEPSIA

Bile Acid Signaling in Neurodegenerative and Neurological Disorders

(2020) Stephanie M. Grant et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?

(2020) Paula Morales et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis

(2020) Ana Pilar Pérez-Acevedo et al.   Pharmaceuticals

Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol

(2019) Jerzy P. Szaflarski et al.   EPILEPSY & BEHAVIOR

5-HT3 Receptor Antagonists in Neurologic and Neuropsychiatric Disorders: The Iceberg Still Lies beneath the Surface

(2019) Gohar Fakhfouri et al.   PHARMACOLOGICAL REVIEWS

Drug–drug interactions with cannabidiol (CBD) appear to have no effect on treatment response in an open-label Expanded Access Program

(2019) Tyler E. Gaston et al.   EPILEPSY & BEHAVIOR

Pharmacogenomics

(2019) Dan M Roden et al.   LANCET

Antioxidative and Anti-Inflammatory Properties of Cannabidiol

(2019) Sinemyiz Atalay et al.   Antioxidants

Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results

(2018) Jerzy P. Szaflarski et al.   EPILEPSIA

Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study

(2018) Jerzy P. Szaflarski et al.   EPILEPSY & BEHAVIOR

The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis

(2018) Linda Kalilani et al.   EPILEPSIA

Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of TRPA1 channel

(2018) Wenzhen Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Keratan Sulfate (KS)-Proteoglycans and Neuronal Regulation in Health and Disease: the importance of KS-glycodynamics and interactive capability with neuroregulatory ligands

(2018) James Melrose   JOURNAL OF NEUROCHEMISTRY

Interactions between cannabidiol and commonly used antiepileptic drugs

(2017) Tyler E. Gaston et al.   EPILEPSIA

Pharmacology of cannabinoids in the treatment of epilepsy

(2017) Tyler E. Gaston et al.   EPILEPSY & BEHAVIOR

National and State Estimates of the Numbers of Adults and Children with Active Epilepsy — United States, 2015

(2017) Matthew M. Zack et al.   MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT

DMETTM (Drug Metabolism Enzymes and Transporters): a pharmacogenomic platform for precision medicine

(2016) Mariamena Arbitrio et al.   Oncotarget

Sugar-dependent modulation of neuronal development, regeneration, and plasticity by chondroitin sulfate proteoglycans

(2015) Gregory M. Miller et al.   EXPERIMENTAL NEUROLOGY

“GAG-ing with the neuron”: The role of glycosaminoglycan patterning in the central nervous system

(2015) Patrice D. Smith et al.   EXPERIMENTAL NEUROLOGY

Genetic variability in the regulation of gene expression in ten regions of the human brain

(2014) Adaikalavan Ramasamy et al.   NATURE NEUROSCIENCE

Statistical power and significance testing in large-scale genetic studies

(2014) Pak C. Sham et al.   NATURE REVIEWS GENETICS

COXPRESdb in 2015: coexpression database for animal species by DNA-microarray and RNAseq-based expression data with multiple quality assessment systems

(2014) Yasunobu Okamura et al.   NUCLEIC ACIDS RESEARCH

Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

(2013) K E Caudle et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Annotation of functional variation in personal genomes using RegulomeDB

(2012) A. P. Boyle et al.   GENOME RESEARCH

G Protein–Coupled Receptor Deorphanizations

(2011) Olivier Civelli et al.   Annual Review of Pharmacology and Toxicology

Dense Genotyping of Candidate Gene Loci Identifies Variants Associated With High-Density Lipoprotein Cholesterol

(2011) Andrew C. Edmondson et al.   Circulation-Cardiovascular Genetics

Cannabidiol, a Major Phytocannabinoid, As a Potent Atypical Inhibitor for CYP2D6

(2011) S. Yamaori et al.   DRUG METABOLISM AND DISPOSITION

Identification of cytochrome P450 enzymes responsible for metabolism of cannabidiol by human liver microsomes

(2011) Rongrong Jiang et al.   LIFE SCIENCES

HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants

(2011) L. D. Ward et al.   NUCLEIC ACIDS RESEARCH

PharmGKB summary

(2011) Caroline F. Thorn et al.   Pharmacogenetics and Genomics

Role of systems pharmacology in understanding drug adverse events

(2010) Seth I. Berger et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Human glucocorticoid receptor isoform β: recent understanding of its potential implications in physiology and pathophysiology

(2009) Tomoshige Kino et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids

(2009) A. Mazur et al.   DRUG METABOLISM AND DISPOSITION

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

Inborn errors of purine and pyrimidine metabolism

(2009) A. Jurecka   JOURNAL OF INHERITED METABOLIC DISEASE

The Epithelial Membrane Protein 1 is a Novel Tight Junction Protein of the Blood—Brain Barrier

(2008) Thorsten Bangsow et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Association between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapy

(2008) Philippe Couvert et al.   PHARMACOGENOMICS