Kallikrein-related peptidases (KLKs) as emerging therapeutic targets: focus on prostate cancer and skin pathologies

Intratherapeutic Biokinetic Measurements, Dosimetry Parameter Estimates, and Monitoring of Treatment Efficacy Using Cerenkov Luminescence Imaging in Preclinical Radionuclide Therapy

(2015) O. V. Timmermand et al.   JOURNAL OF NUCLEAR MEDICINE

Unleashing the therapeutic potential of human kallikrein-related serine proteases

(2015) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

KLK5 Inactivation Reverses Cutaneous Hallmarks of Netherton Syndrome

(2015) Laetitia Furio et al.   PLoS Genetics

Netherton syndrome: defective kallikrein inhibition in the skin leads to skin inflammation and allergy

(2014) Laetitia Furio et al.   BIOLOGICAL CHEMISTRY

Mechanism-based selection of a potent kallikrein-related peptidase 7 inhibitor from a versatile library based on the sunflower trypsin inhibitor SFTI-1

(2014) Simon J. de Veer et al.   BIOPOLYMERS

SPINK5 knockdown in organotypic human skin culture as a model system for Netherton syndrome: effect of genetic inhibition of serine proteases kallikrein 5 and kallikrein 7

(2014) Shirley Wang et al.   EXPERIMENTAL DERMATOLOGY

Targeting metastatic castration-resistant prostate cancer: mechanisms of progression and novel early therapeutic approaches

(2014) Vittore Cereda et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting kallikrein-related peptidases in prostate cancer

(2014) Konstantinos Mavridis et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Vaccine immunotherapy for prostate cancer: from mice to men

(2014) David M. Lubaroff et al.   IMMUNOLOGIC RESEARCH

Structure-Function Analyses of Human Kallikrein-related Peptidase 2 Establish the 99-Loop as Master Regulator of Activity

(2014) Wolfgang Skala et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic kallikrein 5 mice reproduce major cutaneous and systemic hallmarks of Netherton syndrome

(2014) Laetitia Furio et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toward the First Class of Suicide Inhibitors of Kallikreins Involved in Skin Diseases

(2014) Xiao Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Preclinical imaging of kallikrein-related peptidase 2 (hK2) in prostate cancer with a 111In-radiolabelled monoclonal antibody, 11B6

(2014) Oskar Vilhelmsson Timmermand et al.   EJNMMI Research

Selection of 2′F-modified RNA aptamers against prostate-specific antigen and their evaluation for diagnostic and therapeutic applications

(2013) M. Svobodova et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

1,2,4-Triazole derivatives as transient inactivators of kallikreins involved in skin diseases

(2013) Xiao Tan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel IgE antibody targeting the prostate-specific antigen as a potential prostate cancer therapy

(2013) Tracy R Daniels-Wells et al.   BMC CANCER

Netherton syndrome: skin inflammation and allergy by loss of protease inhibition

(2013) Alain Hovnanian   CELL AND TISSUE RESEARCH

Structural Optimization, Biological Evaluation, and Application of Peptidomimetic Prostate Specific Antigen Inhibitors

(2013) Maya B. Kostova et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paclitaxel Resistance and Multicellular Spheroid Formation Are Induced by Kallikrein-Related Peptidase 4 in Serous Ovarian Cancer Cells in an Ascites Mimicking Microenvironment

(2013) Ying Dong et al.   PLoS One

Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer

(2013) Y. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of plasma and tissue kallikreins

(2013) Monika Pathak et al.   THROMBOSIS AND HAEMOSTASIS

Human kallikrein 2 (KLK2) promotes prostate cancer cell growth via function as a modulator to promote the ARA70-enhanced androgen receptor transactivation

(2013) Zhiqun Shang et al.   TUMOR BIOLOGY

Epigenetic regulation of kallikrein-related peptidases: there is a whole new world out there

(2012) Maria D. Pasic et al.   BIOLOGICAL CHEMISTRY

One round of SELEX for the generation of DNA aptamers directed against KLK6

(2012) Steve Arnold et al.   BIOLOGICAL CHEMISTRY

Kallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance

(2012) Margaritis Avgeris et al.   BIOLOGICAL CHEMISTRY

Pro-angiogenic effect of human kallikrein-related peptidase 12 (KLK12) in lung endothelial cells does not depend on kinin-mediated activation of B2 receptor

(2012) Thomas Kryza et al.   BIOLOGICAL CHEMISTRY

Isomannide derivatives as new class of inhibitors for human kallikrein 7

(2012) Renato F. Freitas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting Free Prostate-Specific Antigen for In Vivo Imaging of Prostate Cancer Using a Monoclonal Antibody Specific for Unique Epitopes Accessible on Free Prostate-Specific Antigen Alone

(2012) Susan Evans-Axelsson et al.   CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS

Kallikrein-related peptidases (KLKs): a gene family of novel cancer biomarkers

(2012) Christos K. Kontos et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Prostate cancer vaccines in clinical trials

(2012) David M Lubaroff   Expert Review of Vaccines

Prospective, Randomized, Double-Blind, Vehicle Controlled, Multicenter Phase IIb Clinical Trial of the Pore Forming Protein PRX302 for Targeted Treatment of Symptomatic Benign Prostatic Hyperplasia

(2012) Mostafa M. Elhilali et al.   JOURNAL OF UROLOGY

Cancer immunotherapy: a paradigm shift for prostate cancer treatment

(2012) Dev Karan et al.   Nature Reviews Urology

Targeting the kallikrein-related peptidases for drug development

(2012) Georgia Sotiropoulou et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Imaging Androgen Receptor Signaling with a Radiotracer Targeting Free Prostate-Specific Antigen

(2012) David Ulmert et al.   Cancer Discovery

Protease-Activated Drug Development

(2012) Ki Young Choi et al.   Theranostics

Biological evaluation and docking studies of natural isocoumarins as inhibitors for human kallikrein 5 and 7

(2011) Thiago S.P. Teixeira et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Human kallikrein 4 signal peptide induces cytotoxic T cell responses in healthy donors and prostate cancer patients

(2011) Ray Wilkinson et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Inhibition of Transcription Factor Specificity Protein 1 Alters the Gene Expression Profile of Keratinocytes Leading to Upregulation of Kallikrein-Related Peptidases and Thymic Stromal Lymphopoietin

(2011) Lianghua Bin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Development of a Peptide–Drug Conjugate for Prostate Cancer Therapy

(2011) Wanyi Tai et al.   MOLECULAR PHARMACEUTICS

Mastering the Canonical Loop of Serine Protease Inhibitors: Enhancing Potency by Optimising the Internal Hydrogen Bond Network

(2011) Joakim E. Swedberg et al.   PLoS One

Kallikrein-related peptidase 4 gene (KLK4) in prostate tumors: Quantitative expression analysis and evaluation of its clinical significance

(2011) Margaritis Avgeris et al.   PROSTATE

Synergistic tumor growth-inhibitory effect of the prostate-specific antigen-activated fusion peptide BSD352 for prostate cancer therapy

(2010) Bin Li et al.   ANTI-CANCER DRUGS

Natural and synthetic inhibitors of kallikrein-related peptidases (KLKs)

(2010) Peter Goettig et al.   BIOCHIMIE

Kallikrein-related peptidase genes as promising biomarkers for prognosis and monitoring of human malignancies

(2010) Margaritis Avgeris et al.   BIOLOGICAL CHEMISTRY

Natural and engineered kallikrein inhibitors: an emerging pharmacopoeia

(2010) Joakim E. Swedberg et al.   BIOLOGICAL CHEMISTRY

Selection of DNA aptamer against prostate specific antigen using a genetic algorithm and application to sensing

(2010) Nasa Savory et al.   BIOSENSORS & BIOELECTRONICS

Molecular mechanism of kallikrein-related peptidase 8/neuropsin-induced hyperkeratosis in inflamed skin

(2010) K. Shingaki et al.   BRITISH JOURNAL OF DERMATOLOGY

Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen and the Extended Kallikrein Locus

(2010) Mitchell G. Lawrence et al.   ENDOCRINE REVIEWS

Phase 1 and 2 Studies Demonstrate the Safety and Efficacy of Intraprostatic Injection of PRX302 for the Targeted Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

(2010) Samuel R. Denmeade et al.   EUROPEAN UROLOGY

Prognostic value and biological role of the kallikrein-related peptidases in human malignancies

(2010) Konstantinos Mavridis et al.   Future Oncology

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D3, and Retinoic Acid

(2010) Shin Morizane et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes

(2010) Kenshi Yamasaki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Aptamers as therapeutics

(2010) Anthony D. Keefe et al.   NATURE REVIEWS DRUG DISCOVERY

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Selection of RNA aptamers specific to active prostate-specific antigen

(2009) Sujin Jeong et al.   BIOTECHNOLOGY LETTERS

Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer

(2009) James L. Gulley et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Phase I Clinical Trial of an Adenovirus/Prostate-Specific Antigen Vaccine for Prostate Cancer: Safety and Immunologic Results

(2009) D. M. Lubaroff et al.   CLINICAL CANCER RESEARCH

Prostvac-VF: a vector-based vaccine targeting PSA in prostate cancer

(2009) Ravi A Madan et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Kallikrein-related peptidase-4 initiates tumor–stroma interactions in prostate cancer through protease-activated receptor-1

(2009) Wenbin Wang et al.   INTERNATIONAL JOURNAL OF CANCER

Functional Roles of Human Kallikrein-related Peptidases

(2009) Georgia Sotiropoulou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct intra-tumoral injection of zinc-acetate halts tumor growth in a xenograft model of prostate cancer

(2009) Maulik R Shah et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Kallikrein 5 induces atopic dermatitis–like lesions through PAR2-mediated thymic stromal lymphopoietin expression in Netherton syndrome

(2009) Anaïs Briot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Structures and specificity of the human kallikrein-related peptidases KLK 4, 5, 6, and 7

(2008) Mekdes Debela et al.   BIOLOGICAL CHEMISTRY

Human tissue kallikreins as promiscuous modulators of homeostatic skin barrier functions

(2008) Azza Eissa et al.   BIOLOGICAL CHEMISTRY

Kallikreins as microRNA targets: an in silico and experimental-based analysis

(2008) Tsz-fung F. Chow et al.   BIOLOGICAL CHEMISTRY

A completed KLK activome profile: investigation of activation profiles of KLK9, 10, and 15

(2008) Hyesook Yoon et al.   BIOLOGICAL CHEMISTRY

Tissue Prostate-Specific Antigen Facilitates Refractory Prostate Tumor Progression via Enhancing ARA70-Regulated Androgen Receptor Transactivation

(2008) Y. Niu et al.   CANCER RESEARCH

Kallikrein-related peptidases

(2008) Å. Lundwall et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Potent and Selective Peptidyl Boronic Acid Inhibitors of the Serine Protease Prostate-Specific Antigen

(2008) Aaron M. LeBeau et al.   CHEMISTRY & BIOLOGY

Major Role of Human KLK14 in Seminal Clot Liquefaction

(2008) Nashmil Emami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2

(2008) G. J. Mize et al.   MOLECULAR CANCER RESEARCH

Novel small molecule inhibitors for prostate‐specific antigen

(2008) Hannu Koistinen et al.   PROSTATE

Activation profiles of human kallikrein-related peptidases by proteases of the thrombostasis axis

(2008) Hyesook Yoon et al.   PROTEIN SCIENCE

Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases

(2007) Kristina Stefansson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY