Targeting p21 activated kinase 1 (Pak1) to PAKup Pancreatic Cancer

P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer

(2016) S. Jagadeeshan et al.   ANNALS OF ONCOLOGY

FRAX597, a PAK1 inhibitor, synergistically reduces pancreatic cancer growth when combined with gemcitabine

(2016) Dannel Yeo et al.   BMC CANCER

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Liposome-mediated delivery of the p21 activated kinase-1 (PAK-1) inhibitor IPA-3 limits prostate tumor growth in vivo

(2016) Ahmad Al-Azayzih et al.   Nanomedicine-Nanotechnology Biology and Medicine

Targeting PAK1 in pancreatic stellate cells increases pancreatic cancer survival

(2016) Dannel Yeo et al.   PANCREATOLOGY

The Role of p21-Activated Kinases in Pancreatic Cancer

(2015) Dannel Yeo et al.   PANCREAS

Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor

(2015) Alexei S. Karpov et al.   ACS Medicinal Chemistry Letters

Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pKa Polar Moiety

(2015) Chudi O. Ndubaku et al.   ACS Medicinal Chemistry Letters

Molecular Pathways: Targeting RAC-p21-Activated Serine-Threonine Kinase Signaling in RAS-Driven Cancers

(2014) N. M. Baker et al.   CLINICAL CANCER RESEARCH

Pancreatic stellate cells and pancreas cancer: Current perspectives and future strategies

(2014) Jonathan Haqq et al.   EUROPEAN JOURNAL OF CANCER

Transcriptional regulation of fibronectin by p21-activated kinase-1 modulates pancreatic tumorigenesis

(2014) S Jagadeeshan et al.   ONCOGENE

FRAX597, a Small Molecule Inhibitor of the p21-activated Kinases, Inhibits Tumorigenesis of Neurofibromatosis Type 2 (NF2)-associated Schwannomas

(2013) Silvia Licciulli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IPA-3 Inhibits the Growth of Liver Cancer Cells By Suppressing PAK1 and NF-κB Activation

(2013) Leo Lap-Yan Wong et al.   PLoS One

Pancreatic cancer: why is it so hard to treat?

(2013) Paul E. Oberstein et al.   Therapeutic Advances in Gastroenterology

p21-Activated Kinase 1 Is Required for Efficient Tumor Formation and Progression in a Ras-Mediated Skin Cancer Model

(2012) H. Y. Chow et al.   CANCER RESEARCH

Molecular Pathways: Targeting P21-Activated Kinase 1 Signaling in Cancer--Opportunities, Challenges, and Limitations

(2012) J. Eswaran et al.   CLINICAL CANCER RESEARCH

An allosteric kinase inhibitor binds the p21-activated kinase autoregulatory domain covalently

(2009) J. Viaud et al.   MOLECULAR CANCER THERAPEUTICS

An Isoform-Selective, Small-Molecule Inhibitor Targets the Autoregulatory Mechanism of p21-Activated Kinase

(2008) Sean W. Deacon et al.   CHEMISTRY & BIOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE