KLF2 Mediates the Suppressive Effect of Laminar Flow on Vascular Calcification by Inhibiting Endothelial BMP/SMAD1/5 Signaling

The role of bone morphogenetic protein signaling in vascular calcification

(2020) Peiran Yang et al.   BONE

Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells

(2019) Joan Fernandez Esmerats et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice

(2019) Wencong Song et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammation induces endothelial-to-mesenchymal transition and promotes vascular calcification through downregulation of BMPR2

(2018) Gonzalo Sánchez-Duffhues et al.   JOURNAL OF PATHOLOGY

KLF2 regulates osteoblast differentiation by targeting of Runx2

(2018) Zhenyang Hou et al.   LABORATORY INVESTIGATION

Cardiovascular calcification: artificial intelligence and big data accelerate mechanistic discovery

(2018) Maximillian A. Rogers et al.   Nature Reviews Cardiology

DACH1 stimulates shear stress-guided endothelial cell migration and coronary artery growth through the CXCL12–CXCR4 signaling axis

(2017) Andrew H. Chang et al.   GENES & DEVELOPMENT

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Computational comparison of regional stress and deformation characteristics in tricuspid and bicuspid aortic valve leaflets

(2016) K. Cao et al.   International Journal for Numerical Methods in Biomedical Engineering

Integrin-YAP/TAZ-JNK cascade mediates atheroprotective effect of unidirectional shear flow

(2016) Li Wang et al.   NATURE

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

(2016) Joshua D. Hutcheson et al.   NATURE MATERIALS

Endothelial-to-mesenchymal transition contributes to fibro-proliferative vascular disease and is modulated by fluid shear stress

(2015) Jan-Renier A.J. Moonen et al.   CARDIOVASCULAR RESEARCH

Serine Protease Activation Essential for Endothelial–Mesenchymal Transition in Vascular CalcificationNovelty and Significance

(2015) Jiayi Yao et al.   CIRCULATION RESEARCH

Endothelial microparticles mediate inflammation-induced vascular calcification

(2015) Paula Buendía et al.   FASEB JOURNAL

An Angiographic Tool for Risk Prediction of Side Branch Occlusion in Coronary Bifurcation Intervention

(2015) Kefei Dou et al.   JACC-Cardiovascular Interventions

Endothelial-to-mesenchymal transition drives atherosclerosis progression

(2015) Pei-Yu Chen et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Statins on Serial Coronary Calcification During Atheroma Progression and Regression

(2015) Rishi Puri et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A Role for the Endothelium in Vascular Calcification

(2013) Yucheng Yao et al.   CIRCULATION RESEARCH

Inhibition of Bone Morphogenetic Protein Signaling Reduces Vascular Calcification and Atherosclerosis

(2012) Matthias Derwall et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Bmper Inhibits Endothelial Expression of Inflammatory Adhesion Molecules and Protects Against Atherosclerosis

(2012) Xinchun Pi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

BMP activity controlled by BMPER regulates the proinflammatory phenotype of endothelium

(2011) T. Helbing et al.   BLOOD

Novel random peptide libraries displayed on AAV serotype 9 for selection of endothelial cell-directed gene transfer vectors

(2011) K Varadi et al.   GENE THERAPY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Paracrine Osteogenic Signals via Bone Morphogenetic Protein-2 Accelerate the Atherosclerotic Intimal Calcification In Vivo

(2010) Yusuke Nakagawa et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of Bone Morphogenetic Proteins Protects Against Atherosclerosis and Vascular Calcification

(2010) Yucheng Yao et al.   CIRCULATION RESEARCH

Conversion of vascular endothelial cells into multipotent stem-like cells

(2010) Damian Medici et al.   NATURE MEDICINE

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

Mammalian Krüppel-Like Factors in Health and Diseases

(2010) Beth B. McConnell et al.   PHYSIOLOGICAL REVIEWS

KLF2 Primes the Antioxidant Transcription Factor Nrf2 for Activation in Endothelial Cells

(2008) Joost O. Fledderus et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Altered Shear Stress Stimulates Upregulation of Endothelial VCAM-1 and ICAM-1 in a BMP-4– and TGF-β1–Dependent Pathway

(2008) Philippe Sucosky et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY