Letermovir for the management of cytomegalovirus infection

In VitroDrug Combination Studies of Letermovir (AIC246, MK-8228) with Approved Anti-Human Cytomegalovirus (HCMV) and Anti-HIV Compounds in Inhibition of HCMV and HIV Replication

(2015) Steffen Wildum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Inhibition of Human Cytomegalovirus Replication by Artemisinins: Effects Mediated through Cell Cycle Modulation

(2015) Sujayita Roy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Phenotypic characterization of two naturally occurring human Cytomegalovirus sequence polymorphisms located in a distinct region of ORF UL56 known to be involved in in vitro resistance to letermovir

(2015) Thomas Goldner et al.   ANTIVIRAL RESEARCH

Characterization of Cytomegalovirus Breakthrough Events in a Phase 2 Prophylaxis Trial of Letermovir (AIC246, MK 8228)

(2015) Peter Lischka et al.   JOURNAL OF INFECTIOUS DISEASES

Utility of Leflunomide in the Treatment of Drug Resistant Cytomegalovirus Retinitis

(2015) Lana M. Rifkin et al.   OCULAR IMMUNOLOGY AND INFLAMMATION

Current and Potential Treatments for Ubiquitous but Neglected Herpesvirus Infections

(2014) Jonathan E. Gable et al.   CHEMICAL REVIEWS

Letermovir for Cytomegalovirus Prophylaxis in Hematopoietic-Cell Transplantation

(2014) Roy F. Chemaly et al.   NEW ENGLAND JOURNAL OF MEDICINE

Taming the Transplantation Troll by Targeting Terminase

(2014) Paul D. Griffiths et al.   NEW ENGLAND JOURNAL OF MEDICINE

Geno- and Phenotypic Characterization of Human Cytomegalovirus Mutants SelectedIn Vitroafter Letermovir (AIC246) Exposure

(2013) Thomas Goldner et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Success and failure of artesunate treatment in five transplant recipients with disease caused by drug-resistant cytomegalovirus

(2013) R. Germi et al.   ANTIVIRAL RESEARCH

Fast selection of maribavir resistant cytomegalovirus in a bone marrow transplant recipient

(2013) Axel Schubert et al.   BMC INFECTIOUS DISEASES

CMX001 to Prevent Cytomegalovirus Disease in Hematopoietic-Cell Transplantation

(2013) Francisco M. Marty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Leflunomide as part of the treatment for multidrug-resistant cytomegalovirus disease after lung transplantation: case report and review of the literature

(2013) N.J. Verkaik et al.   Transplant Infectious Disease

Preemptive treatment of Cytomegalovirus infection in kidney transplant recipients with letermovir: results of a Phase 2a study

(2013) Susanne Stoelben et al.   TRANSPLANT INTERNATIONAL

Efficacy and Safety of Maribavir Dosed at 100 mg Orally Twice Daily for the Prevention of Cytomegalovirus Disease in Liver Transplant Recipients: A Randomized, Double-Blind, Multicenter Controlled Trial

(2012) D. J. Winston et al.   AMERICAN JOURNAL OF TRANSPLANTATION

First Report of Successful Treatment of Multidrug-Resistant Cytomegalovirus Disease with the Novel Anti-CMV Compound AIC246

(2011) D. R. Kaul et al.   AMERICAN JOURNAL OF TRANSPLANTATION

In VitroEvaluation of the Activities of the Novel Anticytomegalovirus Compound AIC246 (Letermovir) against Herpesviruses and Other Human Pathogenic Viruses

(2011) Manfred Marschall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants

(2011) Sunwen Chou et al.   ANTIVIRAL RESEARCH

Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation

(2011) Dana G. Wolf et al.   ANTIVIRAL RESEARCH

Cytomegalovirus in Hematopoietic Stem Cell Transplant Recipients

(2011) Per Ljungman et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

The Novel Anticytomegalovirus Compound AIC246 (Letermovir) Inhibits Human Cytomegalovirus Replication through a Specific Antiviral Mechanism That Involves the Viral Terminase

(2011) T. Goldner et al.   JOURNAL OF VIROLOGY

Maribavir prophylaxis for prevention of cytomegalovirus disease in recipients of allogeneic stem-cell transplants: a phase 3, double-blind, placebo-controlled, randomised trial

(2011) Francisco M Marty et al.   LANCET INFECTIOUS DISEASES

In Vitro and In Vivo Activities of the Novel Anticytomegalovirus Compound AIC246

(2010) P. Lischka et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Update on New Antivirals Under Development for the Treatment of Double-Stranded DNA Virus Infections

(2010) L K Dropulic et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Artemisinin-Derived Dimers Have Greatly Improved Anti-Cytomegalovirus Activity Compared to Artemisinin Monomers

(2010) Ravit Arav-Boger et al.   PLoS One

Utility of Leflunomide in the Treatment of Complex Cytomegalovirus Syndromes

(2010) Robin K. Avery et al.   TRANSPLANTATION

Cytomegalovirus in Solid Organ Transplant Recipients

(2009) A. Humar et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Artesunate as a Potent Antiviral Agent in a Patient with Late Drug‐Resistant Cytomegalovirus Infection after Hematopoietic Stem Cell Transplantation

(2008) Michael Y. Shapira et al.   CLINICAL INFECTIOUS DISEASES