Metabolic and redox barriers in the skin exposed to drugs and xenobiotics

Redox Control of Multidrug Resistance and Its Possible Modulation by Antioxidants

(2016) Aysegul Cort et al.   Oxidative Medicine and Cellular Longevity

The Tryptophan-Derived Endogenous Aryl Hydrocarbon Receptor Ligand 6-Formylindolo[3,2- b ]Carbazole Is a Nanomolar UVA Photosensitizer in Epidermal Keratinocytes

(2015) Sophia L. Park et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A potential role for endogenous proteins as sacrificial sunscreens and antioxidants in human tissues

(2015) Sarah A. Hibbert et al.   Redox Biology

Cytochromes P450 and Skin Cancer: Role of Local Endocrine Pathways

(2014) Andrzej Slominski et al.   Anti-Cancer Agents in Medicinal Chemistry

Manganese Superoxide Dismutase-Mediated Inside-Out Signaling in HaCaT Human Keratinocytes and SKH-1 Mouse Skin

(2014) Aaron K. Holley et al.   ANTIOXIDANTS & REDOX SIGNALING

Xenobiotic-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

(2014) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Extrahepatic metabolism at the body's internal–external interfaces

(2014) Ursula Gundert-Remy et al.   DRUG METABOLISM REVIEWS

Local Melatoninergic System as the Protector of Skin Integrity

(2014) Andrzej Slominski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metabolism of melatonin and biological activity of intermediates of melatoninergic pathway in human skin cells

(2013) Tae-Kang Kim et al.   FASEB JOURNAL

Use of natural AhR ligands as potential therapeutic modalities against inflammatory disorders

(2013) Philip B Busbee et al.   NUTRITION REVIEWS

Antimicrobial Impact of Cold Atmospheric Pressure Plasma on Medical Critical Yeasts and Bacteria Cultures

(2013) C. Wiegand et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Use of Human In Vitro Skin Models for Accurate and Ethical Risk Assessment: Metabolic Considerations

(2013) Nicola J. Hewitt et al.   TOXICOLOGICAL SCIENCES

Plant polyphenols and human skin: friends or foes

(2012) Liudmila Korkina et al.   Annals of the New York Academy of Sciences

The AhR twist: ligand-dependent AhR signaling and pharmaco-toxicological implications

(2012) Erwan Guyot et al.   DRUG DISCOVERY TODAY

Xenobiotic metabolism capacities of human skin in comparison with a 3D epidermis model and keratinocyte-based cell culture as in vitro alternatives for chemical testing: activating enzymes (Phase I)

(2012) Christine Götz et al.   EXPERIMENTAL DERMATOLOGY

Do antioxidants impair signaling by reactive oxygen species and lipid oxidation products?

(2012) Etsuo Niki   FEBS LETTERS

Resveratrol Enhances Solar UV-induced Responses in Normal Human Epidermal Keratinocytes

(2012) Saveria Pastore et al.   PHOTOCHEMISTRY AND PHOTOBIOLOGY

Elucidation of Xenobiotic Metabolism Pathways in Human Skin and Human Skin Models by Proteomic Profiling

(2012) Sven van Eijl et al.   PLoS One

Photo-Oxidation Products of Skin Surface Squalene Mediate Metabolic and Inflammatory Responses to Solar UV in Human Keratinocytes

(2012) Vladimir Kostyuk et al.   PLoS One

Langerhans Cells Facilitate Epithelial DNA Damage and Squamous Cell Carcinoma

(2012) B. G. Modi et al.   SCIENCE

Plant Polyphenols Regulate Chemokine Expression and Tissue Repair in Human Keratinocytes Through Interaction with Cytoplasmic and Nuclear Components of Epidermal Growth Factor Receptor System

(2011) Saveria Pastore et al.   ANTIOXIDANTS & REDOX SIGNALING

Superoxide Dismutase 3 Suppresses Hyaluronic Acid Fragments Mediated Skin Inflammation by Inhibition of Toll-Like Receptor 4 Signaling Pathway: Superoxide Dismutase 3 Inhibits Reactive Oxygen Species-Induced Trafficking of Toll-Like Receptor 4 to Lipid Rafts

(2011) Myung-Ja Kwon et al.   ANTIOXIDANTS & REDOX SIGNALING

Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current State of Art

(2011) Lucie Stejskalova et al.   CURRENT DRUG METABOLISM

Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents

(2011) Larry G. Higgins et al.   DRUG METABOLISM REVIEWS

Influence of light on aryl hydrocarbon receptor signaling and consequences in drug metabolism, physiology and disease

(2011) Qiang Ma   Expert Opinion on Drug Metabolism & Toxicology

Plant polyphenols differentially modulate inflammatory responses of human keratinocytes by interfering with activation of transcription factors NFκB and AhR and EGFR–ERK pathway

(2011) Alla I. Potapovich et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Dysfunction of Glutathione S-Transferase Leads to Excess 4-Hydroxy-2-Nonenal and H2O2 and Impaired Cytokine Pattern in Cultured Keratinocytes and Blood of Vitiligo Patients

(2010) Vladimir A. Kostyuk et al.   ANTIOXIDANTS & REDOX SIGNALING

The Chemical Defensive System in the Pathobiology of Idiopathic Environment- Associated Diseases

(2010) L. Korkina et al.   CURRENT DRUG METABOLISM

Pathobiology of Chronic Inflammatory Skin Diseases: Interplay Between Keratinocytes and Immune Cells as a Target for Anti-Inflammatory Drugs

(2010) C. Albanesi et al.   CURRENT DRUG METABOLISM

Interaction between Oxidative Stress Sensor Nrf2 and Xenobiotic-activated Aryl Hydrocarbon Receptor in the Regulation of the Human Phase II Detoxifying UDP-glucuronosyltransferase 1A10

(2010) Sandra Kalthoff et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surface Lipids as Multifunctional Mediators of Skin Responses to Environmental Stimuli

(2010) Chiara De Luca et al.   MEDIATORS OF INFLAMMATION

Expression and Induction of Cytochrome P450 Isoenzymes in Human Skin Equivalents

(2010) M.M. Neis et al.   SKIN PHARMACOLOGY AND PHYSIOLOGY

Biological definition of multiple chemical sensitivity from redox state and cytokine profiling and not from polymorphisms of xenobiotic-metabolizing enzymes

(2010) Chiara De Luca et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative stress in the pathogenesis of psoriasis

(2009) Qiang Zhou et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidant enzymes and lipid peroxidation at the tissue level in patients with stable and active vitiligo

(2009) Ines Dammak et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The Cutaneous Biochemical Redox Barrier: A Component of the Innate Immune Defenses against Sensitization by Highly Reactive Environmental Xenobiotics

(2009) C. Pickard et al.   JOURNAL OF IMMUNOLOGY

Antagonism of Aryl Hydrocarbon Receptor Signaling by 6,2',4'-Trimethoxyflavone

(2009) I. A. Murray et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Introducing the “TCDD-Inducible AhR-Nrf2 Gene Battery”

(2009) Ronnie L. Yeager et al.   TOXICOLOGICAL SCIENCES

Growth factors, cytokines and their receptors as downstream targets of arylhydrocarbon receptor (AhR) signaling pathways

(2008) Thomas Haarmann-Stemmann et al.   BIOCHEMICAL PHARMACOLOGY

AhR protein trafficking and function in the skin

(2008) Togo Ikuta et al.   BIOCHEMICAL PHARMACOLOGY

Detection of Catalase as a major protein target of the lipid peroxidation product 4-HNE and the lack of its genetic association as a risk factor in SLE

(2008) Anil D'souza et al.   BMC Medical Genetics

Metabolism of Plant Polyphenols in the Skin: Beneficial Versus Deleterious Effects

(2008) Liudmila Korkina et al.   CURRENT DRUG METABOLISM

Xenobiotic-Induced Transcriptional Regulation of Xenobiotic Metabolizing Enzymes of the Cytochrome P450 Superfamily in Human Extrahepatic Tissues

(2008) Petr Pavek et al.   CURRENT DRUG METABOLISM

Biotransformation of Drugs in Human Skin

(2008) C. K. Svensson   DRUG METABOLISM AND DISPOSITION

Vitiligo pathogenesis: autoimmune disease, genetic defect, excessive reactive oxygen species, calcium imbalance, or what else?

(2008) Lübeck Ralf Paus et al.   EXPERIMENTAL DERMATOLOGY

The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans

(2008) Emma Wincent et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Skin Sensitization to p-Phenylenediamine: The Diverging Roles of Oxidation and N-Acetylation for Dendritic Cell Activation and the Immune Response

(2008) Pierre Aeby et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

12(R)-Hydroxy-5(Z),8(Z),10(E),14(Z)-eicosatetraenoic Acid [12(R)-HETE], an Arachidonic Acid Derivative, Is an Activator of the Aryl Hydrocarbon Receptor

(2008) Christopher. R. Chiaro et al.   MOLECULAR PHARMACOLOGY

Oxidative stress in environmental-induced carcinogenesis

(2008) Salvador Mena et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

Endothelial glutathione-S-transferase A4-4 protects against oxidative stress and modulates iNOS expression through NF-κB translocation

(2008) Yongzhen Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor

(2007) Linh P. Nguyen et al.   CHEMICAL RESEARCH IN TOXICOLOGY