Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors

Virtual screening, molecular dynamics, and binding free energy calculations on human carbonic anhydrase IX catalytic domain for deciphering potential leads

(2016) Arun John et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Rationale and design of the DP-TRANSFERS project: diabetes prevention-transferring findings from European research to society in Catalonia

(2016) Bernardo Costa et al.   Journal of Translational Medicine

Non-alcoholic steatohepatitis: emerging molecular targets and therapeutic strategies

(2016) Giovanni Musso et al.   NATURE REVIEWS DRUG DISCOVERY

Curcumin inhibits intracellular fatty acid synthase and induces apoptosis in human breast cancer MDA-MB-231 cells

(2016) HUIJIN FAN et al.   ONCOLOGY REPORTS

Progress in the development of fatty acid synthase inhibitors as anticancer targets

(2015) Genevieve E. Mullen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Crystal Structure and Substrate Specificity of Human Thioesterase 2

(2015) Melissa K. Ritchie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fragment-Based Discovery of Potent and Selective DDR1/2 Inhibitors

(2015) Christopher W. Murray et al.   ACS Medicinal Chemistry Letters

You Lose Some, You Win Some: Weight Loss Induces Microbiota and Metabolite Shifts

(2015) Elisabeth M. Bik   EBioMedicine

The fatty acid synthase inhibitor triclosan: repurposing an anti-microbial agent for targeting prostate cancer

(2015) Martin C. Sadowski et al.   Oncotarget

Molecular Mechanisms and New Treatment Strategies for Non-Alcoholic Steatohepatitis (NASH)

(2014) Akinobu Takaki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Alpha-mangostin inhibits intracellular fatty acid synthase and induces apoptosis in breast cancer cells

(2014) Ping Li et al.   Molecular Cancer

A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site

(2014) Mary Ann Hardwicke et al.   Nature Chemical Biology

Physicochemical properties of bacterial pro-inflammatory lipids influence their interaction with apolipoprotein-derived peptides

(2013) Sunil A. Nankar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Mechanisms of Obesity-Induced Gastrointestinal Neoplasia

(2013) José O. Alemán et al.   GASTROENTEROLOGY

Hypothalamic malonyl-CoA and the control of food intake

(2013) Su Gao et al.   PHYSIOLOGY & BEHAVIOR

Fatty Acid Synthase Is a Key Target in Multiple Essential Tumor Functions of Prostate Cancer: Uptake of Radiolabeled Acetate as a Predictor of the Targeted Therapy Outcome

(2013) Yukie Yoshii et al.   PLoS One

Inhibition of Fatty Acid Synthase Attenuates CD44-Associated Signaling and Reduces Metastasis in Colorectal Cancer

(2012) Y. Y. Zaytseva et al.   CANCER RESEARCH

Inhibiting Adipose Tissue Lipogenesis Reprograms Thermogenesis and PPARγ Activation to Decrease Diet-Induced Obesity

(2012) Irfan J. Lodhi et al.   Cell Metabolism

The diagnosis and management of non-alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association

(2012) Naga Chalasani et al.   HEPATOLOGY

Inhibition of fatty acid synthase supresses osteosarcoma cell invasion and migration

(2012) Yong Shu et al.   Indian Journal of Pathology and Microbiology

Prevalence of Obesity and Trends in Body Mass Index Among US Children and Adolescents, 1999-2010

(2012) Cynthia L. Ogden et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Obesity and Trends in the Distribution of Body Mass Index Among US Adults, 1999-2010

(2012) Katherine M. Flegal et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

New Synthetic Inhibitors of Fatty Acid Synthase with Anticancer Activity

(2012) Carlos Turrado et al.   JOURNAL OF MEDICINAL CHEMISTRY

Associations Between Obesity and Cancer: The Role of Fatty Acid Synthase

(2012) D. Wang et al.   JNCI-Journal of the National Cancer Institute

Metabolic intervention on lipid synthesis converging pathways abrogates prostate cancer growth

(2012) V Fritz et al.   ONCOGENE

Blockade of Fatty Acid Synthase Triggers Significant Apoptosis in Mantle Cell Lymphoma

(2012) Pascal Gelebart et al.   PLoS One

Targeted therapy with fatty acid synthase inhibitors in a human prostate carcinoma LNCaP/tk-luc-bearing animal model

(2012) H-W Chen et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Anti-Cancer Drugs Targeting Fatty Acid Synthase (FAS)

(2012) Puspa R. Pandey et al.   Recent Patents on Anti-Cancer Drug Discovery

Imidazopyridine-Based Fatty Acid Synthase Inhibitors That Show Anti-HCV Activity and in Vivo Target Modulation

(2012) Johan D. Oslob et al.   ACS Medicinal Chemistry Letters

Fatty Acid Synthase Inhibitors as Possible Treatment for Cancer

(2012) Ahmed F. Abdel-Magid   ACS Medicinal Chemistry Letters

Fatty acid synthase expression in osteosarcoma and its correlation with pulmonary metastasis

(2012) ZHI LI LIU et al.   Oncology Letters

Fatty acid synthase and liver triglyceride metabolism: Housekeeper or messenger?

(2011) Anne P.L. Jensen-Urstad et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Advances in comparative genetics: influence of genetics on obesity

(2011) Wendy Foulds Mathes et al.   BRITISH JOURNAL OF NUTRITION

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes

(2011) M. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Triclosan: A critical review of the experimental data and development of margins of safety for consumer products

(2010) Joseph V. Rodricks et al.   CRITICAL REVIEWS IN TOXICOLOGY

Multivariate SAR/QSAR of 3-aryl-4-hydroxyquinolin-2(1H)-one derivatives as type I fatty acid synthase (FAS) inhibitors

(2010) Eduardo Borges de Melo   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fatty acid synthase as a potential therapeutic target in cancer

(2010) Richard Flavin et al.   Future Oncology

DNA Packaging-Associated Hyper-Capsid Expansion of Bacteriophage T3

(2010) Philip Serwer et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and function of eukaryotic fatty acid synthases

(2010) Timm Maier et al.   QUARTERLY REVIEWS OF BIOPHYSICS

Novel fatty acid synthase (FAS) inhibitors: Design, synthesis, biological evaluation, and molecular docking studies

(2009) Xiaokui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Fatty Acid Synthase: Association with Insulin Resistance, Type 2 Diabetes, and Cancer

(2009) J. A. Menendez et al.   CLINICAL CHEMISTRY

Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer

(2009) Toshiro Migita et al.   JNCI-Journal of the National Cancer Institute

1-Oxo-3-substitute-isothiochroman-4-carboxylic acid compounds: Synthesis and biological activities of FAS inhibition

(2008) Xiaokui Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The multienzyme architecture of eukaryotic fatty acid synthases

(2008) Marc Leibundgut et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Discovery of GSK837149A, an inhibitor of human fatty acid synthase targeting the β-ketoacyl reductase reaction

(2008) María Jesús Vázquez et al.   FEBS Journal

Fatty acid synthase is up-regulated during hepatitis C virus infection and regulates hepatitis C virus entry and production

(2008) Wei Yang et al.   HEPATOLOGY

Synthesis of Novel β-Lactone Inhibitors of Fatty Acid Synthase

(2008) Robyn D. Richardson et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the fungal fatty acid synthase type I multienzyme complex

(2008) P. Johansson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of a Mammalian Fatty Acid Synthase

(2008) T. Maier et al.   SCIENCE