Current status of quinoxaline and quinoxaline 1,4‐di‐ N ‐oxides derivatives as potential antiparasitic agents

Biological activity of esters of quinoxaline-7-carboxylate 1,4-di-N-oxide against E. histolytica and their analysis as potential thioredoxin reductase inhibitors

(2020) Jacqueline Soto-Sánchez et al.   PARASITOLOGY RESEARCH

What constitutes a neglected tropical disease?

(2020) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Liposome-based nanocarrier loaded with a new quinoxaline derivative for the treatment of cutaneous leishmaniasis

(2020) Juliana Kovalczuk de Oliveira et al.   Materials Science & Engineering C-Materials for Biological Applications

Extracellular vesicles: new targets for vaccines against helminth parasites

(2020) Claire Drurey et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Cell death: a review of the major forms of apoptosis, necrosis and autophagy

(2019) Mark S D’Arcy   CELL BIOLOGY INTERNATIONAL

Biological Evaluation of Esters of Quinoxaline-7-carboxylate 1,4-di-N-oxide as Antigiardiasis Agents

(2019) Elizabeth Barboza-Cabrera et al.   Letters in Drug Design & Discovery

Primaquine–quinoxaline 1,4-di-N-oxide hybrids with action on the exo-erythrocytic forms of Plasmodium induce their effect by the production of reactive oxygen species

(2019) Leonardo Bonilla-Ramírez et al.   MALARIA JOURNAL

Cathepsin L Inhibitors with Activity against the Liver Fluke Identified From a Focus Library of Quinoxaline 1,4-di-N-Oxide Derivatives

(2019) Florencia Ferraro et al.   MOLECULES

Immunity against sexual stage Plasmodium falciparum and Plasmodium vivax parasites

(2019) Roos M. Jong et al.   IMMUNOLOGICAL REVIEWS

Quinoxaline derivatives as potential antitrypanosomal and antileishmanial agents

(2018) Juliana Cogo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Quinoxaline: An insight into the recent pharmacological advances

(2018) Sana Tariq et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A systematic and prospectively validated approach for identifying synergistic drug combinations against malaria

(2018) Yasaman KalantarMotamedi et al.   MALARIA JOURNAL

Apoptotic impact on Brugia malayi by sulphonamido-quinoxaline: search for a novel therapeutic rationale

(2018) Priyanka S. Bhoj et al.   PARASITOLOGY RESEARCH

Genomes of all known members of a Plasmodium subgenus reveal paths to virulent human malaria

(2018) Thomas D. Otto et al.   Nature Microbiology

Novel antimalarial chloroquine- and primaquine-quinoxaline 1,4-di-N-oxide hybrids: Design, synthesis, Plasmodium life cycle stage profile, and preliminary toxicity studies

(2018) Leonardo Bonilla-Ramirez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Insecticide Resistance and Its Intensity in Populations of Malaria Vectors in Colombia

(2018) Lorena I. Orjuela et al.   Biomed Research International

Leishmania treatment and prevention: Natural and synthesized drugs

(2018) Adnan A. Bekhit et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Interplay between Plasmodium falciparum haemozoin and l-arginine: implication for nitric oxide production

(2018) Yolanda Corbett et al.   MALARIA JOURNAL

EAPB0503: An Imiquimod analog with potent in vitro activity against cutaneous leishmaniasis caused by Leishmania major and Leishmania tropica

(2018) Rana El Hajj et al.   PLoS Neglected Tropical Diseases

Discovery of new hit-molecules targeting Plasmodium falciparum through a global SAR study of the 4-substituted-2-trichloromethylquinazoline antiplasmodial scaffold

(2017) Justine Desroches et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heme modulates Trypanosoma cruzi bioenergetics inducing mitochondrial ROS production

(2017) Natália P. Nogueira et al.   FREE RADICAL BIOLOGY AND MEDICINE

In vitro and in vivo assessment of newer quinoxaline–oxadiazole hybrids as antimicrobial and antiprotozoal agents

(2017) Navin B. Patel et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Design, synthesis and antimalarial activity of novel bis{N-[(pyrrolo[1,2-a]quinoxalin-4-yl)benzyl]-3-aminopropyl}amine derivatives

(2017) Jean Guillon et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Trypanocidal Activity of Quinoxaline 1,4 Di-N-oxide Derivatives as Trypanothione Reductase Inhibitors

(2017) Karla Chacón-Vargas et al.   MOLECULES

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Isopropyl quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives induce regulated necrosis-like cell death on Leishmania (Leishmania) mexicana

(2017) Karla Fabiola Chacón-Vargas et al.   PARASITOLOGY RESEARCH

Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents

(2016) Ylenia Baquedano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

In VitroandIn VivoActivities of 2,3-Diarylsubstituted Quinoxaline Derivatives against Leishmania amazonensis

(2016) Vanessa Kaplum et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synthesis and biological evaluation of quinoxaline di- N -oxide derivatives with in vitro trypanocidal activity

(2016) Silvia Pérez-Silanes et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Copper(ii) mixed-ligand polypyridyl complexes with doxycycline – structures and biological evaluation

(2016) Olufunso O. Abosede et al.   DALTON TRANSACTIONS

Current Threat of Triclabendazole Resistance in Fasciola hepatica

(2016) Jane M. Kelley et al.   TRENDS IN PARASITOLOGY

Quinoxaline 1,4-di-N-Oxides: Biological Activities and Mechanisms of Actions

(2016) Guyue Cheng et al.   Frontiers in Pharmacology

PI3K signalling in inflammation

(2015) P.T. Hawkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis and in vitro and in vivo biological evaluation of substituted nitroquinoxalin-2-ones and 2,3-diones as novel trichomonacidal agents

(2015) Alexandra Ibáñez-Escribano et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of novel 2,3-disubstituted quinoxaline derivatives as antileishmanial and antitrypanosomal agents

(2015) Juliana Cogo et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity

(2014) Hiroki Hayase et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Mutagenicity of N-oxide Containing Heterocycles and Related Compounds: Experimental and Theoretical Studies

(2014) Martin Gabay et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel 4-alkapolyenylpyrrolo[1,2-a]quinoxalines as antileishmanial agents – Part III

(2014) Luisa Ronga et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation and Structure-Activity Relationships of New Quinoxaline Derivatives as Anti-Plasmodium falciparum Agents

(2014) Ana Gil et al.   MOLECULES

Initial studies on mechanism of action and cell death of active N-oxide-containing heterocycles in Trypanosoma cruzi epimastigotes in vitro

(2014) DIEGO BENÍTEZ et al.   PARASITOLOGY

Anti-Trypanosoma cruzi and anti-leishmanial activity by quinoxaline-7-carboxylate 1,4-di-N-oxide derivatives

(2014) Juan Carlos Villalobos-Rocha et al.   PARASITOLOGY RESEARCH

A Quinoxaline Derivative as a Potent Chemotherapeutic Agent, Alone or in Combination with Benznidazole, against Trypanosoma cruzi

(2014) Jean Henrique da Silva Rodrigues et al.   PLoS One

Treatment of Erythrocytes with the 2-Cys Peroxiredoxin Inhibitor, Conoidin A, Prevents the Growth of Plasmodium falciparum and Enhances Parasite Sensitivity to Chloroquine

(2014) Mariana Brizuela et al.   PLoS One

Synergy Testing of FDA-Approved Drugs Identifies Potent Drug Combinations against Trypanosoma cruzi

(2014) Joseph D. Planer et al.   PLoS Neglected Tropical Diseases

Orally Active Antischistosomal Early Leads Identified from the Open Access Malaria Box

(2014) Katrin Ingram-Sieber et al.   PLoS Neglected Tropical Diseases

Synthesis and in vitro evaluation of new ethyl and methyl quinoxaline-7-carboxylate 1,4-di-N-oxide against Entamoeba histolytica

(2013) Blanca Estela Duque-Montaño et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Peroxiredoxin-1 from the Human Hookworm Ancylostoma ceylanicum Forms a Stable Oxidized Decamer and Is Covalently Inhibited by Conoidin A

(2013) Jennifer B. Nguyen et al.   CHEMISTRY & BIOLOGY

Novel quinoxaline 1,4-di-N-oxide derivatives as new potential antichagasic agents

(2013) Enrique Torres et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The thioredoxin antioxidant system

(2013) Jun Lu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Complexes of different nitrogen donor heterocyclic ligands with SbCl3 and PhSbCl2 as potential antileishmanial agents against SbIII-sensitive and -resistant parasites

(2013) Edgar H. Lizarazo-Jaimes et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities

(2013) Carlos Barea et al.   MOLECULES

Hunanamycin A, an Antibiotic from a Marine-Derived Bacillus hunanensis

(2013) Youcai Hu et al.   ORGANIC LETTERS

Antiplasmodial and Leishmanicidal Activities of 2-Cyano-3-(4-phenylpiperazine-1-carboxamido) Quinoxaline 1,4-Dioxide Derivatives

(2012) Carlos Barea et al.   MOLECULES

Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A

(2012) Avelina Espinosa et al.   PARASITOLOGY RESEARCH

Identification of Thioredoxin Glutathione Reductase Inhibitors That Kill Cestode and Trematode Parasites

(2012) Fabiana Ross et al.   PLoS One

Critical role for phosphoinositide 3-kinase gamma in parasite invasion and disease progression of cutaneous leishmaniasis

(2012) H. E. Cummings et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioredoxin glutathione reductase: Its role in redox biology and potential as a target for drugs against neglected diseases

(2011) Stefanie Prast-Nielsen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

New salicylamide and sulfonamide derivatives of quinoxaline 1,4-di-N-oxide with antileishmanial and antimalarial activities

(2011) Carlos Barea et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Trypanocidal properties, structure–activity relationship and computational studies of quinoxaline 1,4-di-N-oxide derivatives

(2011) Yannick Estevez et al.   EXPERIMENTAL PARASITOLOGY

3-TrifluoromethylquinoxalineN,N′-Dioxides as Anti-Trypanosomatid Agents. Identification of Optimal Anti-T. cruziAgents and Mechanism of Action Studies

(2011) Diego Benitez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Evolution of apoptosis-like programmed cell death in unicellular protozoan parasites

(2011) Szymon Kaczanowski et al.   Parasites & Vectors

Massive screening yields novel and selective Trypanosoma cruzi triosephosphate isomerase dimer-interface-irreversible inhibitors with anti-trypanosomal activity

(2010) Guzmán Álvarez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Izumiphenazines A−C: Isolation and Structure Elucidation of Phenazine Derivatives fromStreptomycessp. IFM 11204

(2010) Mohamed S. Abdelfattah et al.   JOURNAL OF NATURAL PRODUCTS

Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica

(2010) Anupama Sardar Ghosh et al.   PARASITOLOGY INTERNATIONAL

ESR, electrochemical, molecular modeling and biological evaluation of 4-substituted and 1,4-disubstituted 7-nitroquinoxalin-2-ones as potential anti-Trypanosoma cruzi agents

(2010) Benjamín Aguilera-Venegas et al.   SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY

Identification of conoidin A as a covalent inhibitor of peroxiredoxin II

(2009) Jeralyn D. Haraldsen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates

(2008) Nelilma C. Romeiro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PlasmodiumTelomeric Sequences: Structure, Stability and Quadruplex Targeting by Small Compounds

(2008) Anne De Cian et al.   CHEMBIOCHEM

The aza-analogues of 1,4-naphthoquinones are potent substrates and inhibitors of plasmodial thioredoxin and glutathione reductases and of human erythrocyte glutathione reductase

(2008) Christophe Morin et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

(2008) A. Cavazzuti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA