Discovery of novel antibacterial agents: Recent developments in D‐alanyl‐D‐alanine ligase inhibitors

D-alanine-D-alanine ligase as a model for the activation of ATP-grasp enzymes by monovalent cations

(2020) Jordan L Pederick et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of peptidoglycan synthesis and remodelling

(2020) Alexander J. F. Egan et al.   NATURE REVIEWS MICROBIOLOGY

Pharmacomodulations of the benzoyl-thiosemicarbazide scaffold reveal antimicrobial agents targeting d-alanyl-d-alanine ligase in bacterio

(2020) Alice Ameryckx et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Novel DNA Gyrase-Inhibiting Spiropyrimidinetriones as Potent Antibiotics for Treatment of Infections Caused by Multidrug-Resistant Gram-Positive Bacteria

(2019) Chenghui Shi et al.   JOURNAL OF MEDICINAL CHEMISTRY

DPD-Inspired Discovery of Novel LsrK Kinase Inhibitors: An Opportunity To Fight Antimicrobial Resistance

(2019) Silvia Stotani et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and antibacterial evaluation of novel 15-membered 11a-azahomoclarithromycin derivatives with the 1, 2, 3-triazole side chain

(2019) Yinhui Qin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Comparative fitness analysis of D-cycloserine resistant mutants reveals both fitness-neutral and high-fitness cost genotypes

(2019) Dimitrios Evangelopoulos et al.   Nature Communications

D-Alanyl-D-Alanine Ligase as a Broad-Host-Range Counterselection Marker in Vancomycin-Resistant Lactic Acid Bacteria

(2018) Shenwei Zhang et al.   JOURNAL OF BACTERIOLOGY

The Biological Properties and Potential Interacting Proteins of d-Alanyl-d-alanine Ligase A from Mycobacterium tuberculosis

(2018) et al.   MOLECULES

1-(2-Hydroxybenzoyl)-thiosemicarbazides are promising antimicrobial agents targeting d-alanine-d-alanine ligase in bacterio

(2018) Alice Ameryckx et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Prevalence of nontuberculous mycobacteria and high efficacy of D-cycloserine and its synergistic effect with clarithromycin against Mycobacterium fortuitum and Mycobacterium abscessus

(2018) Azar Dokht Khosravi et al.   Infection and Drug Resistance

A comparative modeling and molecular docking study onMycobacterium tuberculosistargets involved in peptidoglycan biosynthesis

(2016) Zeynab Fakhar et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Structure ofD-alanine-D-alanine ligase fromYersinia pestis: nucleotide phosphate recognition by the serine loop

(2016) Huyen-Thi Tran et al.   Acta Crystallographica Section D-Structural Biology

Low Serum Concentrations of Moxifloxacin, Prothionamide, and Cycloserine on Sputum Conversion in Multi-Drug Resistant TB

(2015) Seung Heon Lee et al.   YONSEI MEDICAL JOURNAL

Comparative modeling and molecular docking studies of d-Alanine:d-alanine ligase: a target of antibacterial drugs

(2014) Syed Sikander Azam et al.   MEDICINAL CHEMISTRY RESEARCH

Metabolomics Analysis Identifies d-Alanine-d-Alanine Ligase as the Primary Lethal Target of d-Cycloserine in Mycobacteria

(2013) Steven Halouska et al.   JOURNAL OF PROTEOME RESEARCH

Function of the d-Alanine:d-Alanine Ligase Lid Loop: A Molecular Modeling and Bioactivity Study

(2012) Martina Hrast et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular docking studies on analogues of quercetin with d-alanine:d-alanine ligase of Helicobacter pylori

(2012) Salam Pradeep Singh et al.   MEDICINAL CHEMISTRY RESEARCH

6-Arylpyrido[2,3-d]pyrimidines as Novel ATP-Competitive Inhibitors of Bacterial D-Alanine:D-Alanine Ligase

(2012) Veronika Škedelj et al.   PLoS One

Ellipticines and 9-acridinylamines as inhibitors of d-alanine:d-alanine ligase

(2011) Blaž Vehar et al.   BIOORGANIC & MEDICINAL CHEMISTRY

WHO guidelines for the programmatic management of drug-resistant tuberculosis: 2011 update

(2011) D. Falzon et al.   EUROPEAN RESPIRATORY JOURNAL

The urgent need for new antibacterial agents

(2011) R. Wise et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Tackling antibiotic resistance

(2011) Karen Bush et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial cell wall assembly: still an attractive antibacterial target

(2011) Timothy D.H. Bugg et al.   TRENDS IN BIOTECHNOLOGY

Crystallization and preliminary X-ray analysis of aD-alanyl-D-alanine ligase (EcDdlB) fromEscherichia coli

(2010) Sarah Batson et al.   Acta Crystallographica Section F-Structural Biology and Crystallization Communications

Structure of theMycobacterium tuberculosisd-Alanine:d-Alanine Ligase, a Target of the Antituberculosis Drug d-Cycloserine

(2010) John B. Bruning et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Peptidoglycan biosynthesis machinery: A rich source of drug targets

(2010) Ankur Gautam et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

How antibiotics kill bacteria: from targets to networks

(2010) Michael A. Kohanski et al.   NATURE REVIEWS MICROBIOLOGY

Design and synthesis of new hydroxyethylamines as inhibitors of d-alanyl-d-lactate ligase (VanA) and d-alanyl-d-alanine ligase (DdlB)

(2009) Matej Sova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

DD-Ligases as a Potential Target for Antibiotics: Past, Present and Future

(2009) I. Tytgat et al.   CURRENT MEDICINAL CHEMISTRY

An oldie but a goodie – cell wall biosynthesis as antibiotic target pathway

(2009) Tanja Schneider et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

A novel assay of bacterial peptidoglycan synthesis for natural product screening

(2009) Ryo Murakami et al.   JOURNAL OF ANTIBIOTICS

A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity

(2009) Michael Y. Galperin et al.   PROTEIN SCIENCE

Structure-Based Design of Benzoxazoles as new Inhibitors for D-Alanyl – D-Alanine Ligase

(2009) Isabelle Tytgat et al.   Quantitative structure-activity relationships & combinatorial science

ATP competitive inhibitors of d-alanine–d-alanine ligase based on protein kinase inhibitor scaffolds

(2008) Gemma Triola et al.   BIOORGANIC & MEDICINAL CHEMISTRY

d-Alanine:d-alanine ligase as a new target for the flavonoids quercetin and apigenin

(2008) Dalei Wu et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Discovery of New Inhibitors ofd-Alanine:d-Alanine Ligase by Structure-Based Virtual Screening†

(2008) Andreja Kovač et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cycloserine

(2008)   TUBERCULOSIS