The origins of SARS-CoV-2: A critical review

SARS-CoV-2 variants with mutations at the S1/S2 cleavage site are generated in vitro during propagation in TMPRSS2-deficient cells

(2021) Michihito Sasaki et al.   PLoS Pathogens

A genome-wide CRISPR screen identifies host factors that regulate SARS-CoV-2 entry

(2021) Yunkai Zhu et al.   Nature Communications

SARS-CoV-2 spike variants exhibit differential infectivity and neutralization resistance to convalescent or post-vaccination sera

(2021) Alona Kuzmina et al.   Cell Host & Microbe

Higher infectivity of the SARS‐CoV‐2 new variants is associated with K417N/T, E484K, and N501Y mutants: An insight from structural data

(2021) Abbas Khan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Timing the SARS-CoV-2 index case in Hubei province

(2021) Jonathan Pekar et al.   SCIENCE

Cryo-electron microscopy structures of the N501Y SARS-CoV-2 spike protein in complex with ACE2 and 2 potent neutralizing antibodies

(2021) Xing Zhu et al.   PLOS BIOLOGY

The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets

(2021) Thomas P. Peacock et al.   Nature Microbiology

Identification of novel bat coronaviruses sheds light on the evolutionary origins of SARS-CoV-2 and related viruses

(2021) Hong Zhou et al.   CELL

Novel Canine Coronavirus Isolated from a Hospitalized Pneumonia Patient, East Malaysia

(2021) Anastasia N Vlasova et al.   CLINICAL INFECTIOUS DISEASES

The origins and potential future of SARS-CoV-2 variants of concern in the evolving COVID-19 pandemic

(2021) Sarah P. Otto et al.   CURRENT BIOLOGY

The COVID lab-leak hypothesis: what scientists do and don’t know

(2021) Amy Maxmen et al.   NATURE

Structural basis for enhanced infectivity and immune evasion of SARS-CoV-2 variants

(2021) Yongfei Cai et al.   SCIENCE

Animal sales from Wuhan wet markets immediately prior to the COVID-19 pandemic

(2021) Xiao Xiao et al.   Scientific Reports

In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin

(2021) Sakshi Piplani et al.   Scientific Reports

Receptor recognition by novel coronavirus from Wuhan: An analysis based on decade-long structural studies of SARS

(2020) Yushun Wan et al.   JOURNAL OF VIROLOGY

IQ-TREE 2: New Models and Efficient Methods for Phylogenetic Inference in the Genomic Era

(2020) Bui Quang Minh et al.   MOLECULAR BIOLOGY AND EVOLUTION

A new coronavirus associated with human respiratory disease in China

(2020) Fan Wu et al.   NATURE

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak

(2020) Liangjun Chen et al.   Emerging Microbes & Infections

A Mouse Model of SARS-CoV-2 Infection and Pathogenesis

(2020) Shi-Hui Sun et al.   Cell Host & Microbe

Identification of a novel coronavirus causing severe pneumonia in human

(2020) Li-Li Ren et al.   CHINESE MEDICAL JOURNAL

A Novel Bat Coronavirus Closely Related to SARS-CoV-2 Contains Natural Insertions at the S1/S2 Cleavage Site of the Spike Protein

(2020) Hong Zhou et al.   CURRENT BIOLOGY

A Forgotten Episode of Marburg Virus Disease: Belgrade, Yugoslavia, 1967

(2020) Elizabeta S. Ristanović et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Isolation of SARS-CoV-2-related coronavirus from Malayan pangolins

(2020) Kangpeng Xiao et al.   NATURE

The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice

(2020) Linlin Bao et al.   NATURE

The proximal origin of SARS-CoV-2

(2020) Kristian G. Andersen et al.   NATURE MEDICINE

A palindromic RNA sequence as a common breakpoint contributor to copy-choice recombination in SARS-COV-2

(2020) William R. Gallaher   ARCHIVES OF VIROLOGY

Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

(2020) Tyler N. Starr et al.   CELL

Tracking Changes in SARS-CoV-2 Spike: Evidence that D614G Increases Infectivity of the COVID-19 Virus

(2020) Bette Korber et al.   CELL

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

(2020) Ahmed O. Hassan et al.   CELL

Natural transmission of bat-like SARS-CoV-2PRRA variants in COVID-19 patients

(2020) Yik Chun Wong et al.   CLINICAL INFECTIOUS DISEASES

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

(2020) Benjamin Israelow et al.   JOURNAL OF EXPERIMENTAL MEDICINE

SARS-coronavirus-2 replication in Vero E6 cells: replication kinetics, rapid adaptation and cytopathology

(2020) Natacha S. Ogando et al.   JOURNAL OF GENERAL VIROLOGY

Identification of common deletions in the spike protein of SARS-CoV-2

(2020) Zhe Liu et al.   JOURNAL OF VIROLOGY

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

(2020) Hongjing Gu et al.   SCIENCE

Wuhan coronavirus hunter Shi Zhengli speaks out

(2020) Jon Cohen   SCIENCE

Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein

(2020) Andrew D. Davidson et al.   Genome Medicine

A dynamic nomenclature proposal for SARS-CoV-2 lineages to assist genomic epidemiology

(2020) Andrew Rambaut et al.   Nature Microbiology

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

(2020) Maciej F. Boni et al.   Nature Microbiology

Rampant C→U Hypermutation in the Genomes of SARS-CoV-2 and Other Coronaviruses: Causes and Consequences for Their Short- and Long-Term Evolutionary Trajectories

(2020) P. Simmonds   mSphere

A Mouse-Adapted SARS-CoV-2 Induces Acute Lung Injury and Mortality in Standard Laboratory Mice

(2020) Sarah R. Leist et al.   CELL

SARS-CoV-2 growth, furin-cleavage-site adaptation and neutralization using serum from acutely infected hospitalized COVID-19 patients

(2020) William B. Klimstra et al.   JOURNAL OF GENERAL VIROLOGY

A mouse-adapted model of SARS-CoV-2 to test COVID-19 countermeasures

(2020) Kenneth H. Dinnon et al.   NATURE

Origin and cross-species transmission of bat coronaviruses in China

(2020) Alice Latinne et al.   Nature Communications

Comparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 Infection

(2020) Raveen Rathnasinghe et al.   Emerging Microbes & Infections

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity

(2020) Erik Volz et al.   CELL

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

(2020) Carina Conceicao et al.   PLOS BIOLOGY

Minimap2: pairwise alignment for nucleotide sequences

(2018) Heng Li   BIOINFORMATICS

Serological Evidence of Bat SARS-Related Coronavirus Infection in Humans, China

(2018) Ning Wang et al.   VIROLOGICA SINICA

Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

(2017) Ben Hu et al.   PLoS Pathogens

Pre-fusion structure of a human coronavirus spike protein

(2016) Robert N. Kirchdoerfer et al.   NATURE

Isolation and Characterization of a Novel Bat Coronavirus Closely Related to the Direct Progenitor of Severe Acute Respiratory Syndrome Coronavirus

(2015) Xing-Lou Yang et al.   JOURNAL OF VIROLOGY

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

(2015) Vineet D Menachery et al.   NATURE MEDICINE

The Reemergent 1977 H1N1 Strain and the Gain-of-Function Debate

(2015) Michelle Rozo et al.   mBio

Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor

(2013) Xing-Yi Ge et al.   NATURE

Metagenomic Analysis of Viruses from Bat Fecal Samples Reveals Many Novel Viruses in Insectivorous Bats in China

(2012) Xingyi Ge et al.   JOURNAL OF VIROLOGY

Activation of the SARS coronavirus spike protein via sequential proteolytic cleavage at two distinct sites

(2009) S. Belouzard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cleavage of Group 1 Coronavirus Spike Proteins: How Furin Cleavage Is Traded Off against Heparan Sulfate Binding upon Cell Culture Adaptation

(2008) C. A. M. de Haan et al.   JOURNAL OF VIROLOGY