Review
Biochemistry & Molecular Biology
Prarthana Gopinath, Revathi Paramasivam Oviya, Gopal Gopisetty
Summary: Estrogen plays a significant role in tumorigenesis, but some breast cancer patients develop resistance to estrogen. Non-classical estrogen signaling through various pathways is important in cancer development and clinical treatment.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Eric B. Wright, Deborah A. Lannigan
Summary: This review focuses on the molecular mechanisms regulating oestrogen homeostasis in the mammary gland. ERK1/2 and RSK2 play roles in maintaining homeostasis by controlling ER alpha responsiveness. RSK2 acts as a positive regulator of translation, providing both positive and negative signals to maintain oestrogen responsiveness. Additionally, ERK1/2-RSK2 interacts with hedgehog signalling and the HIPPO pathway to regulate oestrogen levels and ER alpha-mediated transcription.
Article
Cell Biology
Deep R. R. Sharma, Bokun Cheng, Rauhin Sahu, Xusheng Zhang, Rana Mehdizadeh, Divya Singh, Dumitru Iacobas, Praveen Ballabh
Summary: Prematurely-born infants cared for in neonatal units exhibit memory and learning deficits. The dysmaturation of neurons in the hippocampal dentate gyrus is associated with elevated levels of PSD95, NMDR2A, and IGF1. Treatment with 17β-estradiol (E2) is hypothesized to improve neurogenesis and synaptogenesis in the hippocampal dentate gyrus, reversing cognitive deficits in premature newborns. E2 treatment in a rabbit model of prematurity increased the number of neuronal progenitors and synapse density in the hippocampal dentate gyrus, restored cognitive function, and influenced gene interactions related to IGF1 signaling.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Chi Sun Liau, Praveena Mogan, Warren Thomas
Summary: Estrogen plays a significant role in the initiation and progression of lung carcinoma, particularly in women. Circulating estrogen may be a significant risk factor for women's susceptibility to lung carcinoma and provide an alternative approach for more targeted therapy.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Plant Sciences
Satoshi Okada, Gui J. Lei, Naoki Yamaji, Sheng Huang, Jian F. Ma, Keiichi Mochida, Takashi Hirayama
Summary: The peptide FEP1 plays a pivotal role in iron movement and maintaining iron levels in vascular tissues in Arabidopsis. It regulates the translocation of iron and not its uptake in roots, and is involved in the iron deficiency response.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Oncology
Emanuele Perrone, Ilaria Capasso, Francesca De Felice, Diana Giannarelli, Giorgia Dinoi, Alessandro Petrecca, Luca Palmieri, Aniello Foresta, Camilla Nero, Damiano Arciuolo, Domenica Lorusso, Gian Franco Zannoni, Giovanni Scambia, Francesco Fanfani
Summary: This study aims to evaluate the impact of the oestrogen receptor (ER) profile on oncologic outcomes in the new endometrial cancer (EC) risk classification. Immunohistochemistry (IHC) analyses were performed to assess the presence/absence of ER and other molecular factors. The results show that ER status has a significant impact on survival outcomes in EC, regardless of risk class and other molecular factors.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medicine, General & Internal
Josilene Maria Ferreira Pinheiro, Ketyllem Tayanne da Silva Costa, Clelia de Oliveira Lyra, Flavia Andreia Pereira Soares dos Santos, Rodrigo Pinheiro de Toledo Vianna, Kenya de Lima Silva, Fabia Barbosa de Andrade
Summary: This study aimed to evaluate the care provided to newborns in public maternity hospitals in Natal, Brazil, and identify factors associated with adequate care. The findings revealed shortcomings in the care actions for newborns, highlighting the need for reassessing skills and coordinating actions in the child's healthcare network.
Review
Biochemistry & Molecular Biology
Anastasia I. I. Palamarchuk, Elena I. I. Kovalenko, Maria A. A. Streltsova
Summary: TERT, as a core component of telomerase, is not only responsible for lengthening telomeres, but also involved in multiple signaling pathways with various intracellular localizations and functions. Upregulation of TERT expression and increased telomerase activity in cancer and somatic cells are associated with improved survival and persistence.
Review
Cell Biology
Johanna Vogenstahl, Marta Parrilla, Amparo Acker-Palmer, Marta Segarra
Summary: The vascular system evolved before the nervous system and symbiotic communication exists between them, which is not limited to nutrient and oxygen supply. Blood vessels play an important role in neurogenesis during the development of the vertebrate central nervous system (CNS).
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Kelly Holloway, Fiona A. Miller
Summary: This article investigates the regulatory regime for molecular diagnostics in the US, highlighting the key role of private consultants in coverage and reimbursement. The study emphasizes the production of evidence as a critical part of the process and argues that consultants act as regulatory intermediaries, benefiting their clients' financial interests. The article suggests that public policy discussions should reconsider whose interests are represented in the regulatory regime.
SOCIAL SCIENCE & MEDICINE
(2022)
Article
Clinical Neurology
Nelsan Pourhadi, Amani Meaidi, Soren Friis, Christian Torp-Pedersen, Lina S. Morch
Summary: The study aimed to investigate the association between vaginal oestradiol use and the development of meningioma and glioma. The results showed a slightly increased incidence of meningioma but no significant association with glioma in women using vaginal oestradiol tablets.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Food Science & Technology
Hui Liu, Hui Guan, Fatao He, Ye Song, Feng Li, Dongxiao Sun-Waterhouse, Dapeng Li
Summary: Tea phenolic compounds, such as catechins and theaflavins, have abundant antioxidant and anti-inflammatory properties. Clinical studies have shown that drinking tea or taking catechin supplements on a daily basis can enhance the body's natural antioxidant defense system and inhibit the production of inflammatory factors. However, the epigenetic mechanisms involved in the regulation of chronic diseases by tea phenolic compounds have not been fully studied.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Laurent Kiger, Julia Keith, Abdullah Freiwan, Alfonso G. Fernandez, Heather Tillman, Brant E. Isakson, Mitchell J. Weiss, Christophe Lechauve
Summary: This study examines the expression and cellular localization of eNOS, CyB5a, and CyB5R3 in mouse arterial endothelial cells, showing that alpha-globin can be reduced by two independent redox systems, CyB5R3/CyB5a and eNOS. These findings provide new insights into the regulation of blood vessel contractility.
Review
Endocrinology & Metabolism
Nikki Le, Sarah Sayers, Veronica Mata-Pacheco, Edward J. Wagner
Summary: This article summarizes the important role of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in energy balance regulation and explores how its actions are influenced by sex and dynamic changes in energy status. The article provides an overview of energy homeostasis, introduces the components of the homeostatic and hedonic energy balance circuitries, discusses sex differences and the activational effects of sex steroid hormones. Finally, it explores the multifaceted role of PACAP in regulating homeostatic and hedonic feeding in different regions.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liang Pan, Shiyu Su, Yuanyuan Li, Di Liu, Lingyu Shen, Haiying Wang, Jiayu Wen, Hui Hu, Ruwen Zheng
Summary: The effects of acupuncture and finasteride on the expression of oestrogen receptors (ERs) alpha and beta in testosterone-induced benign prostatic hyperplasia (BPH) in rats were investigated. The results showed that both acupuncture and finasteride significantly improved the distribution of ERs and could improve BPH. Additionally, ER beta mRNA expression in the finasteride group was significantly different compared to the control and acupuncture groups, suggesting a potential mechanism of action for the treatment of BPH.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)