Editorial Material
Public, Environmental & Occupational Health
Saurabh Kumar
Summary: The COVID-19 pandemic has caused a large number of infections and deaths in the country, with several infectious variants circulating. Preventive strategies include large-scale testing, tracing, treatment, lockdowns in hotspot areas, and mass vaccination.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Jeyanthi Anandraj, Yuvaraj Krishnamoorthy, Parthibane Sivanantham, Jilisha Gnanadas, Sitanshu Sekhar Kar
Summary: A study conducted in Puducherry showed an increase in vaccine hesitancy and refusal rates during the second wave of the COVID-19 pandemic. Confidence in the efficacy and safety of the COVID-19 vaccine declined over time, contributing to the rise in vaccine hesitancy and refusal among the study cohort, with over one-third of individuals refusing vaccination during the second wave of the pandemic.
HUMAN VACCINES & IMMUNOTHERAPEUTICS
(2021)
Article
Public, Environmental & Occupational Health
Lovely Jain, Jatina Vij, Prakasini Satapathy, Venkatesan Chakrapani, Binod Patro, Sitanshu Sekhar Kar, Ritesh Singh, Star Pala, Lalit Sankhe, Bhavesh Modi, Surya Bali, Neeti Rustagi, Vineeth Rajagopal, Tanvi Kiran, Kapil Goel, Arun Kumar Aggarwal, Madhu Gupta, Bijaya Kumar Padhi
Summary: The study found that Indian college students had relatively high levels of positive intentions to receive COVID-19 vaccines, although about one-third were not sure or unwilling to receive the vaccine, indicating possible vaccine hesitancy. Informational campaigns and other strategies to address vaccine hesitancy are needed to promote uptake of COVID-19 vaccines.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Infectious Diseases
Purva Asrani, Keshav Tiwari, Mathew Suji Eapen, M. D. Imtaiyaz Hassan, Sukhwinder Singh Sohal
Summary: This article discusses the high risk faced by India in the second wave of the pandemic and proposes possible solutions to contain the viral spread. It emphasizes the importance of implementing effective vaccination programs, speeding up diagnosis, managing hospital aids, and implementing COVID-appropriate behavior in rural areas.
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
(2022)
Article
Microbiology
Arnab Sarkar, Alok Kumar Chakrabarti, Shanta Dutta
Summary: COVID-19 outbreak started in late 2020 and India experienced significant growth in cases from the first wave to the second wave. The population aged 11-60 years was most affected, and the emergence of new variants led to a sharp increase in daily confirmed cases.
Article
Pediatrics
Sushma Malik, Dipty Jain, Chandrakant M. Bokade, Shakira Savaskar, Laxmikant S. Deshmukh, Poonam Wade, Abhishek D. Madhura, Milind Suryawanshi, Sachin T. Bandichhode, Sachin B. Bodhgire, Sarika Zala, Smita D. Mahale, Deepak N. Modi, Rakesh Waghmare, Suchitra Surve, Rahul K. Gajbhiye
Summary: The study examined outcomes in neonates of mothers with COVID-19 during the first and second waves of the pandemic. The second wave resulted in higher rates of preterm birth, neonatal ICU admissions, neonatal complications, birth asphyxia, prematurity, and neonatal resuscitation compared to the first wave. However, the prevalence of SARS-CoV-2 infection in neonates was comparable between the two waves.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Immunology
Meredith G. Dixon, Susan E. Reef, Laura A. Zimmerman, Gavin B. Grant
Summary: Lessons learned from the global rubella epidemic of 1963-1965 can provide valuable insights for the rapid rollout of COVID-19 vaccines as a key strategy to end the global pandemic. The experience of rubella vaccine implementation highlights critical elements of a vaccination program, including clearly defined goals and strategies, regular data-driven revisions, and evaluations to identify the most effective vaccine.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
James M. Trauer, Michael J. Lydeamore, Gregory W. Dalton, David Pilcher, Michael T. Meehan, Emma S. McBryde, Allen C. Cheng, Brett Sutton, Romain Ragonnet
Summary: Victoria, Australia successfully controlled the second wave of COVID-19 through aggressive policy interventions, with estimates showing that individual-level effects of physical distancing and face coverings were significant in reducing the spread of the virus. The multi-faceted interventions led to a dramatic reversal in the epidemic trajectory, with face coverings playing a particularly important role.
NATURE COMMUNICATIONS
(2021)
Article
Public, Environmental & Occupational Health
Arielle Kaim, Maya Siman-Tov, Eli Jaffe, Bruria Adini
Summary: This study demonstrates the benefits of educational programs in improving attitudes and acceptability towards COVID-19 vaccination. Vaccinated individuals and those intending to get vaccinated show higher levels of knowledge, trust, and importance of vaccines, with significant positive correlations found between personal resilience, trust in authorities, and vaccine acceptance.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Immunology
Velayudhan Mohan Kumar, Seithikurippu R. Pandi-Perumal, Ilya Trakht, Sadras Panchatcharam Thyagarajan
Summary: India has started a large-scale COVID-19 vaccination program, with four domestically developed vaccines already approved. The country has the capacity to meet its vaccination needs and has established sufficient manpower and cold-chain infrastructure for the initial phase. Additionally, India has taken urgent measures to expand vaccine manufacturing capacity and implemented an efficient digital system for vaccine administration.
Article
Multidisciplinary Sciences
Rajesh Ranjan, Aryan Sharma, Mahendra K. Verma
Summary: The second wave of COVID-19 in India, starting from February 11, 2021, has been hitting the country hard with nearly triple the daily cases compared to the first wave. The study shows that the virus spread is complex and highly transmissible, with exponential infection rates. Despite lower case fatality rates compared to the first wave, increasing pressure on the healthcare system suggests the need for effective administrative intervention to control the rapid growth of the epidemic.
Article
Immunology
Pritu Dhalaria, Himanshu Arora, Ajeet Kumar Singh, Mansi Mathur, Ajai S. Kumar
Summary: Our study examines the factors influencing COVID-19 vaccination coverage in India, including vaccine hesitancy, socioeconomic factors, and multidimensional deprivations. We find that vaccine hesitancy and multidimensional poverty have a negative impact on vaccination coverage. Gender also plays a significant role in the relationship between internet access and vaccine coverage.
Article
Cardiac & Cardiovascular Systems
Manuela De Michele, Joshua Kahan, Irene Berto, Oscar G. Schiavo, Marta Iacobucci, Danilo Toni, Alexander E. Merkler
Summary: The risk of stroke and cerebrovascular disease complicating SARS-CoV-2 infection has been extensively reported. The rapid development and mass vaccination of DNA and mRNA vaccines against SARS-CoV-2 have led to rare but catastrophic cases of thrombosis. This review provides an overview of stroke and cerebrovascular complications of SARS-CoV-2 infection, as well as vaccinations, with a focus on vaccine-induced immune thrombotic thrombocytopenia. A therapeutic protocol is proposed based on available data.
CIRCULATION RESEARCH
(2022)
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Infectious Diseases
Radhakrishna Muttineni, R. N. Binitha, Kalyani Putty, Kavitha Marapakala, K. P. Sandra, Jaslin Panyam, Aravind Vemula, Shashi Mohan Singh, Subin Balachandran, Viroji S. T. Rao, Anand Kumar Kondapi
Summary: This study analyzed the spike protein mutations of SARS-CoV-2 in India during the second wave of the COVID-19 pandemic. The researchers identified numerous amino acid mutations in the S protein and categorized them into different lineages. Some of these mutations were found to have implications for infectivity, pathogenicity, and vaccine efficacy. The study highlights the importance of continuous monitoring and research on viral mutations for the development of effective prevention strategies.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Review
Biotechnology & Applied Microbiology
Manojit Bhattacharya, Srijan Chatterjee, Ashish Ranjan Sharma, Sang-Soo Lee, Chiranjib Chakraborty
Summary: The Delta variant of the SARS-CoV-2 virus is a highly infectious variant that has caused significant damage during the pandemic. This review focuses on the factors that contribute to its infectivity, the important mutations it carries, and its clinical manifestations and mortality compared to other variants. Practical strategies to minimize the spread of the Delta variant are also discussed.
FOLIA MICROBIOLOGICA
(2023)
Review
Green & Sustainable Science & Technology
Chiranjib Chakraborty, Ashish Ranjan Sharma, Garima Sharma, Manojit Bhattacharya, Sang-Soo Lee
Summary: This article reviews the current status of global microbial diversity, focusing on microbial biodiversity in marine and terrestrial ecosystems. The study demonstrates how 'Biodiversity Informatics' can assist scientists in mapping the diversity of recorded microbial species in different habitats. Additionally, it highlights the use of databases to explore microbial biodiversity and other species of fauna and flora.
ENVIRONMENT DEVELOPMENT AND SUSTAINABILITY
(2023)
Article
Immunology
Chiranjib Chakraborty, Manojit Bhattacharya, Srijan Chatterjee, Ashish Ranjan Sharma, Rudra P. Saha, Kuldeep Dhama, Govindasamy Agoramoorthy
Summary: Pattern recognition is crucial in integrative bioinformatics to determine the structural patterns of proteins in viruses such as SARS-CoV-2. This study identifies the patterns of SARS-CoV-2 proteins to understand the structure-function relationships. Various models and algorithms were used, and the functionality of proteins was found to be unique.
Letter
Surgery
Chiranjib Chakraborty, Srijan Chatterjee, Manojit Bhattacharya, Hitesh Chopra, Prosun Bhattacharya, Md. Aminul Islam, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Chiranjib Chakraborty, Manojit Bhattacharya, Hitesh Chopra, Md. Aminul Islam, Gutulla Saikumar, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Hitesh Chopra, Sandip Chakraborty, Shopnil Akash, Chiranjib Chakraborty, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Kuldeep Dhama, Lawrence S. Tuglo, Chiranjib Chakraborty, Gutulla Saikumar
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Surgery
Chiranjib Chakraborty, Manojit Bhattacharya, Hitesh Chopra, Prosun Bhattacharya, Md. Aminul Islam, Kuldeep Dhama
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Letter
Engineering, Biomedical
Chiranjib Chakraborty, Manojit Bhattacharya, Sang-Soo Lee
Summary: Recently, there has been a growing interest in AI-guided ChatGPT, with various applications being explored, including in the medical field. The number of publications on this topic is also increasing. However, researchers have discovered that ChatGPT sometimes provides partly correct or false information. Therefore, this article calls for the development of an AI-enabled, next-generation, advanced ChatGPT or large language models (LLMs) to ensure that people can obtain accurate and error-free medical information.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Letter
Engineering, Biomedical
Soumen Pal, Manojit Bhattacharya, Sang-Soo Lee, Chiranjib Chakraborty
Summary: Large language models or ChatGPT have gained significant attention and usage in various fields, including biomedical research and engineering. However, it has been found that ChatGPT may provide incorrect or outdated information, which calls for the development of a domain-specific ChatBot for the biomedical field. This domain-specific artificial intelligence device would revolutionize biomedical engineering and research by offering error-free, more accurate, and up-to-date information.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Editorial Material
Medicine, Research & Experimental
Chiranjib Chakraborty, Manojit Bhattacharya
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Editorial Material
Medicine, Research & Experimental
Srijan Chatterjee, Manojit Bhattacharya, Kuldeep Dhama, Sang-Soo Lee, Chiranjib Chakraborty
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Article
Public, Environmental & Occupational Health
Chiranjib Chakraborty, Manojit Bhattacharya, G. Saikumar, Abdulrahman Alshammari, Metab Alharbi, Sang-Soo Lee, Kuldeep Dhama
Summary: This study analyzed the spread of hMPXV1 in European countries using bioinformatics and statistical methods. It identified several sublineages and observed microevolution of the virus in Europe. The study also developed statistical models to analyze the monthly frequency counts of these sublineages. The findings are important for understanding the epidemiological patterns of MPX in Europe and for developing strategies to combat the virus.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)
