Synthesis of new substituted pyridine derivatives as potent anti-liver cancer agents through apoptosis induction: In vitro, in vivo, and in silico integrated approaches

Global Trends in Incidence Rates of Primary Adult Liver Cancers: A Systematic Review and Meta-Analysis

(2020) Paramita Dasgupta et al.   Frontiers in Oncology

Molecular docking, anti-proliferative activity and induction of apoptosis in human liver cancer cells treated with androstane derivatives: Implication of PI3K/AKT/mTOR pathway

(2020) Shahad W. Kattan et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Design, synthesis and antiproliferative activity of new amine, amino acid and dipeptide-coupled benzamides as potential sigma-1 receptor

(2020) Eman Youssef et al.   Journal of the Iranian Chemical Society

Discovery of New Apoptosis-Inducing Agents for Breast Cancer Based on Ethyl 2-Amino-4,5,6,7-Tetra Hydrobenzo[b]Thiophene-3-Carboxylate: Synthesis, In Vitro, and In Vivo Activity Evaluation

(2020) Emad M. Gad et al.   MOLECULES

Triaryl dicationic DNA minor-groove binders with antioxidant activity display cytotoxicity and induce apoptosis in breast cancer

(2020) Mohamed S. Nafie et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Synthesis, characterization of some pyrazine derivatives as anti-cancer agents: In vitro and in Silico approaches

(2020) Eman S. Tantawy et al.   JOURNAL OF MOLECULAR STRUCTURE

Antimicrobial and antiproliferative activities of novel synthesized 6‐(quinolin‐2‐ylthio) pyridine derivatives with molecular docking study as multi‐targeted JAK2/STAT3 inhibitors

(2020) Mohamed S. Nafie et al.   Chemical Biology & Drug Design

Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cells

(2020) Mohamed S. Nafie et al.   BIOORGANIC & MEDICINAL CHEMISTRY

New series of fused pyrazolopyridines: Synthesis, molecular modeling, antimicrobial, antiquorum-sensing and antitumor activities

(2019) N.S. El-Gohary et al.   BIOORGANIC CHEMISTRY

Discovery of novel functionalized 1,2,4-triazoles as PARP-1 inhibitors in breast cancer: Design, synthesis and antitumor activity evaluation

(2019) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, molecular modeling and anti-cancer evaluation of a series of quinazoline derivatives

(2019) Ahmed I. Khodair et al.   CARBOHYDRATE RESEARCH

Screening of different drug design tools to predict the mode of action of steroidal derivatives as anti-cancer agents

(2019) Mohamed S. Nafie et al.   STEROIDS

New pyrazolopyridine analogs: Synthesis, antimicrobial, antiquorum-sensing and antitumor screening

(2018) N.S. El-Gohary et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, antimicrobial, antiquorum-sensing and antitumor evaluation of new series of pyrazolopyridine derivatives

(2018) N.S. El-Gohary et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design and synthesis of new phthalazine-based derivatives as potential EGFR inhibitors for the treatment of hepatocellular carcinoma

(2018) Ahmed T.A. Boraei et al.   BIOORGANIC CHEMISTRY

Design, selective alkylation and X-ray crystal structure determination of dihydro-indolyl-1,2,4-triazole-3-thione and its 3-benzylsulfanyl analogue as potent anticancer agents

(2017) Ahmed T.A. Boraei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and in vitro biological evaluation of novel diaminothiophene scaffolds as antitumor and anti-influenza virus agents. Part 2

(2017) Khurshed Bozorov et al.   RSC Advances

Targeting Pim kinases for cancer treatment: opportunities and challenges

(2015) Bich Thuy Le et al.   Future Medicinal Chemistry

Discovery of 2-[1-(4,4-Difluorocyclohexyl)piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide (NMS-P118): A Potent, Orally Available, and Highly Selective PARP-1 Inhibitor for Cancer Therapy

(2015) Gianluca Papeo et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pan-PIM Kinase Inhibition Provides a Novel Therapy for Treating Hematologic Cancers

(2014) P. D. Garcia et al.   CLINICAL CANCER RESEARCH

Abnormal hematopoietic phenotypes in Pim kinase triple knockout mice

(2013) Ningfei An et al.   Journal of Hematology & Oncology

Structure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors

(2013) Matthew T. Burger et al.   ACS Medicinal Chemistry Letters

Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

(2011) Arup K. Ghose et al.   ACS Chemical Neuroscience

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

(2010) David C. Pryde et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pim-1 expression and monoclonal antibody targeting in human leukemia cell lines

(2009) Jie Li et al.   EXPERIMENTAL HEMATOLOGY