Design and synthesis of novel quinazolinone-pyrazole derivatives as potential α-glucosidase inhibitors: Structure-activity relationship, molecular modeling and kinetic study

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in Streptozotocin -induced diabetic albino Wistar rats

(2021) Muhammad Taha et al.   BIOORGANIC CHEMISTRY

Synthesis of benzimidazole based hydrazones as non‐sugar based α‐glucosidase inhibitors: Structure activity relation and molecular docking

(2021) Muhammad Umair Ahmad et al.   DRUG DEVELOPMENT RESEARCH

Discovery of novel pyrido-pyrrolidine hybrid compounds as alpha-glucosidase inhibitors and alternative agent for control of type 1 diabetes

(2020) Tania Luthra et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploring Quinazolinones as Anticonvulsants by Molecular Fragmentation Approach: Structural Optimization, Synthesis and Pharmacological Evaluation Studies

(2020) Vinod G. Ugale et al.   ChemistrySelect

Probing 2-acetylbenzofuran hydrazones and their metal complexes as α-glucosidase inhibitors

(2020) Samra Khan et al.   BIOORGANIC CHEMISTRY

Design and synthesis of novel pyridazine N-aryl acetamides: In-vitro evaluation of α-glucosidase inhibition, docking, and kinetic studies

(2020) Setareh Moghimi et al.   BIOORGANIC CHEMISTRY

One-pot multicomponent synthesis of novel 3, 4-dihydro-3-methyl-2(1H)-quinazolinone derivatives and their biological evaluation as potential antioxidants, enzyme inhibitors, antimicrobials, cytotoxic and anti-inflammatory agents

(2020) Samra Farooq et al.   Arabian Journal of Chemistry

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics

(2019) Danish Shahzad et al.   MOLECULES

New benzyl pyridinium derivatives bearing 2,4-dioxochroman moiety as potent agents for treatment of Alzheimer’s disease: Design, synthesis, biological evaluation, and docking study

(2019) Marjan Mollazadeh et al.   BIOORGANIC CHEMISTRY

Green synthesis, biological evaluation, molecular docking studies and 3D-QSAR analysis of novel phenylalanine linked quinazoline-4(3H)-one-sulphonamide hybrid entities distorting the malarial reductase activity in folate pathway

(2019) Tarosh S. Patel et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, Synthesis, Docking Studies and Biological Activities Novel 2,3-Diaryl-4-Quinazolinone Derivatives as Anti-HIV-1 Agents

(2019) Zahra Hajimahdi et al.   CURRENT HIV RESEARCH

Michaelis–Menten Graphs, Lineweaver–Burk Plots, and Reaction Schemes: Investigating Introductory Biochemistry Students’ Conceptions of Representations in Enzyme Kinetics

(2019) Jon-Marc G. Rodriguez et al.   JOURNAL OF CHEMICAL EDUCATION

Penicamide A, A Unique N,N′-Ketal Quinazolinone Alkaloid from Ascidian-Derived Fungus Penicillium sp. 4829

(2019) Senhua Chen et al.   Marine Drugs

Design, synthesis, molecular modelling, ADME prediction and anti-hyperglycemic evaluation of new pyrazole-triazolopyrimidine hybrids as potent α-glucosidase inhibitors

(2019) Vinay Pogaku et al.   BIOORGANIC CHEMISTRY

Synthesis and biological evaluation of coumarin derivatives as α-glucosidase inhibitors

(2019) Xue-Tao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities

(2018) Shuangjie Shu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, α- glucosidase inhibition and molecular docking study of coumarin based derivatives

(2018) Muhammad Taha et al.   BIOORGANIC CHEMISTRY

Evaluation of α -glucosidase inhibiting potentials with docking calculations of synthesized arylidene-pyrazolones

(2018) Faryal Chaudhry et al.   BIOORGANIC CHEMISTRY

Oxindole based oxadiazole hybrid analogs: Novel α -glucosidase inhibitors

(2018) Muhammad Taha et al.   BIOORGANIC CHEMISTRY

Design, synthesis, docking study, α-glucosidase inhibition, and cytotoxic activities of acridine linked to thioacetamides as novel agents in treatment of type 2 diabetes

(2018) Maryam Mohammadi-Khanaposhtani et al.   BIOORGANIC CHEMISTRY

Synthesis, in vitro α-glucosidase inhibitory potential and molecular docking study of thiadiazole analogs

(2018) Muhammad Tariq Javid et al.   BIOORGANIC CHEMISTRY

New 6-amino-pyrido[2,3- d ]pyrimidine-2,4-diones as novel agents to treat type 2 diabetes: A simple and efficient synthesis, α -glucosidase inhibition, molecular modeling and kinetic study

(2018) Mehdi Adib et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Research progress in quinazoline derivatives as multi-target tyrosine kinase inhibitors

(2018) Hao Jin et al.   HETEROCYCLIC COMMUNICATIONS

Synthesis and anticancer activity of novel quinazolinone and benzamide derivatives

(2018) Maher Abd El-Aziz Mahmoud El-Hashash et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Molecular Dynamics Simulation for All

(2018) Scott A. Hollingsworth et al.   NEURON

Xanthenone-based hydrazones as potent α-glucosidase inhibitors: Synthesis, solid state self-assembly and in silico studies

(2018) Qamar-un-Nisa Tariq et al.   BIOORGANIC CHEMISTRY

Design and synthesis of novel quinazolinone-1,2,3-triazole hybrids as new anti-diabetic agents: In vitro α-glucosidase inhibition, kinetic, and docking study

(2018) Mina Saeedi et al.   BIOORGANIC CHEMISTRY

Design and synthesis of novel sulphamide tethered quinazolinone hybrids as potential antitumor agents

(2018) Ramineni Venkatesh et al.   JOURNAL OF MOLECULAR STRUCTURE

Antidiabetic, antidyslipidemic and toxicity profile of ENV-2: A potent pyrazole derivative against diabetes and related diseases

(2017) Eduardo Hernández-Vázquez et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Design, synthesis, structure–activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists

(2016) Shuangjie Shu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A simple and efficient synthesis of novel inhibitors of alpha-glucosidase based on benzimidazole skeleton and molecular docking studies

(2016) Musa Özil et al.   BIOORGANIC CHEMISTRY

Synthesis and Evaluation of α-Glucosidase and Pancreatic Lipase Inhibition by Quinazolinone-Coumarin Hybrids

(2016) Emre Menteşe et al.   Chemistry of Heterocyclic Compounds

The therapeutic voyage of pyrazole and its analogs: A review

(2016) Mohemmed Faraz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Arylquinazolin-4(3H)-ones: A new class of α-glucosidase inhibitors

(2015) Kulsoom Javaid et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors

(2015) Ahmed Kamal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 1,3-diaryl pyrazole derivatives as potential antibacterial and anti-inflammatory agents

(2015) Ya-Ru Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of novel pyrazole-containing benzamides as potent RORγ inverse agonists

(2015) Tao Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: Efficient synthesis, biological assessment and docking simulation study

(2015) Mehdi Khoobi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cyclopentyl-pyrimidine based analogues as novel and potent IGF-1R inhibitor

(2015) Valmik Aware et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2

(2015) Dinesh Manvar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

(2015) Li-Gang Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Therapeutic potential of α-glucosidase inhibitors in type 2 diabetes mellitus: an evidence-based review

(2015) Shashank R Joshi et al.   EXPERT OPINION ON PHARMACOTHERAPY

Efficient ultrasound-assisted synthesis, spectroscopic, crystallographic and biological investigations of pyrazole-appended quinolinyl chalcones

(2015) R. Prasath et al.   JOURNAL OF MOLECULAR STRUCTURE

Synthesis and biological evaluation of some novel pyrazole, isoxazole, benzoxazepine, benzothiazepine and benzodiazepine derivatives bearing an aryl sulfonate moiety as antimicrobial and anti-inflammatory agents

(2015) Babasaheb V. Kendre et al.   Arabian Journal of Chemistry

Ultrasound-assisted one-pot four-component synthesis of novel 2-amino-3-cyanopyridine derivatives bearing 5-imidazopyrazole scaffold and their biological broadcast

(2014) Piyush N. Kalaria et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazole-5-carboxamides, novel inhibitors of receptor for advanced glycation end products (RAGE)

(2014) Young Taek Han et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis, and biological evaluation of quinazoline derivatives as α-glucosidase inhibitors

(2014) Venkateshwarlu Gurram et al.   MEDICINAL CHEMISTRY RESEARCH

Discovery of pyrazole as C-terminus of selective BACE1 inhibitors

(2013) Yiquan Zou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

In vivo potential antidiabetic activity of a novel zinc coordination compound based on 3-carboxy-pyrazole

(2013) Marta E. López-Viseras et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Measuring and comparing structural fluctuation patterns in large protein datasets

(2012) Edvin Fuglebakk et al.   BIOINFORMATICS

Synthesis and evaluation of novel 2-butyl-4-chloro-1-methylimidazole embedded chalcones and pyrazoles as angiotensin converting enzyme (ACE) inhibitors

(2011) Srinivas Kantevari et al.   BIOORGANIC & MEDICINAL CHEMISTRY

α-Glucosidase inhibitors in diabetes: efficacy in NIDDM subjects

(2010) M. TOELLER   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

Assessing the performance of the molecular mechanics/Poisson Boltzmann surface area and molecular mechanics/generalized Born surface area methods. II. The accuracy of ranking poses generated from docking

(2010) Tingjun Hou et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Synthesis and Biological Characterisation of NovelN-Alkyl-Deoxynojirimycin α-Glucosidase Inhibitors

(2009) Amy J. Rawlings et al.   CHEMBIOCHEM

Construction of habitat suitability models (HSMs) for benthic macroinvertebrate and their applications to instream environmental flows: A case study in Xiangxi River of Three Gorges Reservior region, China

(2009) Fengqing Li et al.   Progress in Natural Science-Materials International

One-Pot Synthesis of Some New Semicarbazone, Thiosemicarbazone, and Hydrazone Derivatives of 1-Phenyl-3-Arylpyrazole-4-Carboxaldehyde from Acetophenone Phenylhydrazones Using Vilsmeier–Haack Reagent

(2009) Rashmi Pundeer et al.   SYNTHETIC COMMUNICATIONS