Synthesis and antiproliferative screening of novel doubly modified colchicines containing urea, thiourea and guanidine moieties

An insight into the anticancer potential of carbamates and thiocarbamates of 10-demethoxy-10-methylaminocolchicine

(2021) Julia Krzywik et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Antiproliferative Activity and Molecular Docking Studies of Novel Doubly Modified Colchicine Amides and Sulfonamides as Anticancer Agents

(2020) Julia Krzywik et al.   MOLECULES

New Series of Double-Modified Colchicine Derivatives: Synthesis, Cytotoxic Effect and Molecular Docking

(2020) Julia Krzywik et al.   MOLECULES

Synthesis, structure, computational and molecular docking studies of asymmetrically di-substituted ureas containing carboxyl and phosphoryl hydrogen bond acceptor functional groups

(2019) Obinna C. Okpareke et al.   JOURNAL OF MOLECULAR STRUCTURE

Design and synthesis of novel C 14 -urea-tetrandrine derivatives with potent anti-cancer activity

(2018) Junjie Lan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Arylureas derived from colchicine: Enhancement of colchicine oncogene downregulation activity

(2018) Víctor Blasco et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and antimalarial evaluation of amide and urea derivatives based on the thiaplakortone A natural product scaffold

(2015) Brett D. Schwartz et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

4-Chlorocolchicine derivatives bearing a thiourea side chain at the C-7 position as potent anticancer agents

(2014) Hiroyuki Nishiyama et al.   MedChemComm

Guanylated Polymethacrylates: A Class of Potent Antimicrobial Polymers with Low Hemolytic Activity

(2013) Katherine E. S. Locock et al.   BIOMACROMOLECULES

Design, synthesis and anti-tuberculosis activity of 1-adamantyl-3-heteroaryl ureas with improved in vitro pharmacokinetic properties

(2013) E. Jeffrey North et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological activities of thiourea containing sorafenib analogs as antitumor agents

(2012) Jianwen Yao et al.   BIOORGANIC & MEDICINAL CHEMISTRY

SAR analysis of a series of acylthiourea derivatives possessing broad-spectrum antiviral activity

(2012) James R. Burgeson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

N-Aryl-N′-(chroman-4-yl)ureas and thioureas display in vitro anticancer activity and selectivity on apoptosis-resistant glioblastoma cells: Screening, synthesis of simplified derivatives, and structure–activity relationship analysis

(2012) Eric Goffin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isoprenyl-thiourea and urea derivatives as new farnesyl diphosphate analogues: Synthesis and in vitro antimicrobial and cytotoxic activities

(2012) José M. Vega-Pérez et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Colchicine and its various physicochemical and biological aspects

(2012) Sameer Sapra et al.   MEDICINAL CHEMISTRY RESEARCH

The chemistry and biology of organic guanidine derivatives

(2012) Roberto G. S. Berlinck et al.   NATURAL PRODUCT REPORTS

Colchicine poisoning: the dark side of an ancient drug

(2010) Yaron Finkelstein et al.   CLINICAL TOXICOLOGY

Colchicine in clinical medicine. A guide for internists

(2010) Giuseppe Cocco et al.   European Journal of Internal Medicine

Design, synthesis and biological evaluation of novel triazole, urea and thiourea derivatives of quinoline against Mycobacterium tuberculosis

(2009) Ram Shankar Upadhayaya et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antitumor activity of optically active thiourea and their 2-aminobenzothiazole derivatives: A novel class of anticancer agents

(2008) S.N. Manjula et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY