Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors

A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models

(2019) Hwi-Ho Lee et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

A review on mPGES-1 inhibitors: From preclinical studies to clinical applications

(2019) Filip Bergqvist et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury

(2018) Bryan H. Norman et al.   JOURNAL OF MEDICINAL CHEMISTRY

GRC 27864, novel, microsomal prostaglandin E synthase-1 enzyme inhibitor: phase 1 study to evaluate safety, PK and biomarkers in healthy, adult subjects

(2018) S. Sant et al.   OSTEOARTHRITIS AND CARTILAGE

A Novel Phenylsulfonamide Ameliorates the Cognitive Impairment in Mice Induced by Scopolamine

(2018) Sun Young Kim et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data

(2017) Christopher E. Pollard et al.   TOXICOLOGICAL SCIENCES

Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study

(2016) Minju Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents

(2016) Eun Beul Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Chemistry and biology of microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors as novel anti-inflammatory agents: recent developments and current status

(2016) Puneet Khurana et al.   RSC Advances

Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib

(2015) Y Jin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Identification of novel mPGES-1 inhibitors through screening of a chemical library

(2012) Sung-Jun Park et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation

(2012) Graciela B. Arhancet et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17

(2009) Alain Li-Wan-Po et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review

(2009) A. Koeberle et al.   CURRENT MEDICINAL CHEMISTRY

Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1

(2008) A. Koeberle et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas

(2008) Simo Mattila et al.   NEUROPATHOLOGY