Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors
出版年份 2021 全文链接
标题
Discovery of N-amido-phenylsulfonamide derivatives as novel microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors
作者
关键词
Inflammation, PGE, 2, Bioisosteric replacement, Molecular docking, mPGES-1 inhibitor
出版物
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 41, Issue -, Pages 127992
出版商
Elsevier BV
发表日期
2021-03-27
DOI
10.1016/j.bmcl.2021.127992
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- A novel mPGES-1 inhibitor alleviates inflammatory responses by downregulating PGE2 in experimental models
- (2019) Hwi-Ho Lee et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- A review on mPGES-1 inhibitors: From preclinical studies to clinical applications
- (2019) Filip Bergqvist et al. PROSTAGLANDINS & OTHER LIPID MEDIATORS
- Identification and Mitigation of Reactive Metabolites of 2-Aminoimidazole-Containing Microsomal Prostaglandin E Synthase-1 Inhibitors Terminated Due to Clinical Drug-Induced Liver Injury
- (2018) Bryan H. Norman et al. JOURNAL OF MEDICINAL CHEMISTRY
- GRC 27864, novel, microsomal prostaglandin E synthase-1 enzyme inhibitor: phase 1 study to evaluate safety, PK and biomarkers in healthy, adult subjects
- (2018) S. Sant et al. OSTEOARTHRITIS AND CARTILAGE
- A Novel Phenylsulfonamide Ameliorates the Cognitive Impairment in Mice Induced by Scopolamine
- (2018) Sun Young Kim et al. BULLETIN OF THE KOREAN CHEMICAL SOCIETY
- An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data
- (2017) Christopher E. Pollard et al. TOXICOLOGICAL SCIENCES
- Hit-to-lead optimization of phenylsulfonyl hydrazides for a potent suppressor of PGE2 production: Synthesis, biological activity, and molecular docking study
- (2016) Minju Kim et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents
- (2016) Eun Beul Park et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Chemistry and biology of microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitors as novel anti-inflammatory agents: recent developments and current status
- (2016) Puneet Khurana et al. RSC Advances
- Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib
- (2015) Y Jin et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Identification of novel mPGES-1 inhibitors through screening of a chemical library
- (2012) Sung-Jun Park et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Discovery and SAR of PF-4693627, a potent, selective and orally bioavailable mPGES-1 inhibitor for the potential treatment of inflammation
- (2012) Graciela B. Arhancet et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Pharmacogenetics of CYP2C19: functional and clinical implications of a new variant CYP2C19*17
- (2009) Alain Li-Wan-Po et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Inhibitors of the Microsomal Prostaglandin E2 Synthase-1 as Alternative to Non Steroidal Anti-Inflammatory Drugs (NSAIDs) – A Critical Review
- (2009) A. Koeberle et al. CURRENT MEDICINAL CHEMISTRY
- Licofelone Suppresses Prostaglandin E2 Formation by Interference with the Inducible Microsomal Prostaglandin E2 Synthase-1
- (2008) A. Koeberle et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The terminal prostaglandin synthases mPGES-1, mPGES-2, and cPGES are all overexpressed in human gliomas
- (2008) Simo Mattila et al. NEUROPATHOLOGY
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started