Towards the enzymatic synthesis of phosphorothioate containing LNA oligonucleotides

Antisense technology: an overview and prospectus

(2021) Stanley T. Crooke et al.   NATURE REVIEWS DRUG DISCOVERY

Enzymatic Synthesis of Designer DNA Using Cyclic Reversible Termination and a Universal Template

(2020) Kendall Hoff et al.   ACS Synthetic Biology

Enhancing Terminal Deoxynucleotidyl Transferase Activity on Substrates with 3′ Terminal Structures for Enzymatic De Novo DNA Synthesis

(2020) Sebastian Barthel et al.   Genes

Synthesis and polymerase recognition of a pyrrolocytidine TNA triphosphate

(2020) Hui Mei et al.   BIOPOLYMERS

Effect of metal shielding on the enzymatic construction of artificial base pairs

(2020) Marie Flamme et al.   CHEMBIOCHEM

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

Evolving a Thermostable Terminal Deoxynucleotidyl Transferase

(2020) Jasmine Puay Suan Chua et al.   ACS Synthetic Biology

Enzymatic Formation of an Artificial Base Pair Using a Modified Purine Nucleoside Triphosphate

(2020) Marie Flamme et al.   ACS Chemical Biology

Modified nucleic acids: replication, evolution, and next-generation therapeutics

(2020) Karen Duffy et al.   BMC BIOLOGY

Enzymatic DNA synthesis enters new phase

(2020) Michael Eisenstein   NATURE BIOTECHNOLOGY

A Multifunctional LNA Oligo-Based Strategy Blocks Androgen Receptor Expression And Transactivation Activity In Prostate Cancer Cells

(2020) Daniela Castanotto et al.   Molecular Therapy-Nucleic Acids

(S)-5′-C-Aminopropyl-2′-O-methyl nucleosides enhance antisense activity in cultured cells and binding affinity to complementary single-stranded RNA

(2020) Ryohei Kajino et al.   BIOORGANIC & MEDICINAL CHEMISTRY

DNA Polymerase Variants with High Processivity and Accuracy for Encoding and Decoding Locked Nucleic Acid Sequences

(2020) Hidekazu Hoshino et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Phosphorothioate nucleic acids for probing metal binding, biosensing and nanotechnology

(2020) Runjhun Saran et al.   COORDINATION CHEMISTRY REVIEWS

Kinetic analysis of N-alkylaryl carboxamide hexitol nucleotides as substrates for evolved polymerases

(2019) Marleen Renders et al.   NUCLEIC ACIDS RESEARCH

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index

(2019) Wen Shen et al.   NATURE BIOTECHNOLOGY

On the enzymatic formation of metal base pairs with thiolated and pKa-perturbed nucleotides

(2019) Fabienne Levi-Acobas et al.   CHEMBIOCHEM

Terminator-free template-independent enzymatic DNA synthesis for digital information storage

(2019) Henry H. Lee et al.   Nature Communications

In vitro and in vivo properties of therapeutic oligonucleotides containing non-chiral 3′ and 5′ thiophosphate linkages

(2019) Jörg Duschmalé et al.   NUCLEIC ACIDS RESEARCH

Systemic Evaluation of Chimeric LNA/2′OMe Steric Blockers for Myotonic Dystrophy Type 1 Therapy

(2019) Melina Christou et al.   Nucleic Acid Therapeutics

Expanding the chemical diversity of TNA with tUTP derivatives that are substrates for a TNA polymerase

(2018) Hui Mei et al.   CHEMICAL COMMUNICATIONS

De novo DNA synthesis using polymerase-nucleotide conjugates

(2018) Sebastian Palluk et al.   NATURE BIOTECHNOLOGY

2-Allyl- and Propargylamino-dATPs for Site-Specific Enzymatic Introduction of a Single Modification in the Minor Groove of DNA

(2018) Ján Matyašovský et al.   CHEMISTRY-A EUROPEAN JOURNAL

Unlocking P(V): Reagents for chiral phosphorothioate synthesis

(2018) Kyle W. Knouse et al.   SCIENCE

Terminal deoxynucleotidyl transferase in synthesis and modification of nucleic acids

(2018) Ivo Sarac et al.   CHEMBIOCHEM

Synthesis and polymerase activity of a fluorescent cytidine TNA triphosphate analogue

(2017) Hui Mei et al.   NUCLEIC ACIDS RESEARCH

Locked Nucleic Acid Gapmers and Conjugates Potently Silence ADAM33 , an Asthma-Associated Metalloprotease with Nuclear-Localized mRNA

(2017) Hannah M. Pendergraff et al.   Molecular Therapy-Nucleic Acids

Hepatotoxicity of high affinity gapmer antisense oligonucleotides is mediated by RNase H1 dependent promiscuous reduction of very long pre-mRNA transcripts

(2015) Sebastien A. Burel et al.   NUCLEIC ACIDS RESEARCH

Polymerase synthesis of oligonucleotides containing a single chemically modified nucleobase for site-specific redox labelling

(2013) Petra Ménová et al.   CHEMICAL COMMUNICATIONS

Structures of Intermediates along the Catalytic Cycle of Terminal Deoxynucleotidyltransferase: Dynamical Aspects of the Two-Metal Ion Mechanism

(2013) Jérôme Gouge et al.   JOURNAL OF MOLECULAR BIOLOGY

Enzymatic polymerisation involving 2′-amino-LNA nucleotides

(2012) Marie W. Johannsen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Locked vs. unlocked nucleic acids (LNA vs. UNA): contrasting structures work towards common therapeutic goals

(2011) Meghan A. Campbell et al.   CHEMICAL SOCIETY REVIEWS

Polymerase-directed synthesis of C5-ethynyl locked nucleic acids

(2010) Rakesh N. Veedu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Study on Suitability of KOD DNA Polymerase for Enzymatic Production of Artificial Nucleic Acids Using Base/Sugar Modified Nucleoside Triphosphates

(2010) Masayasu Kuwahara et al.   MOLECULES

Smart conferring of nuclease resistance to DNA by 3′-end protection using 2′,4′-bridged nucleoside-5′-triphosphates

(2009) Masayasu Kuwahara et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY